{"id":"https://openalex.org/W2007480979","doi":"https://doi.org/10.1089/mdr.1995.1.249","title":"Successful Treatment of Persistent Bacteremia due to Vancomycin-Resistant, Ampicillin-Resistant Enterococcus faecium","display_name":"Successful Treatment of Persistent Bacteremia due to Vancomycin-Resistant, Ampicillin-Resistant Enterococcus faecium","publication_year":1995,"publication_date":"1995-10-01","ids":{"openalex":"https://openalex.org/W2007480979","doi":"https://doi.org/10.1089/mdr.1995.1.249","mag":"2007480979","pmid":"https://pubmed.ncbi.nlm.nih.gov/9158783"},"language":"en","primary_location":{"id":"doi:10.1089/mdr.1995.1.249","doi":"https://doi.org/10.1089/mdr.1995.1.249","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mdr.1995.1.249","pdf_url":null,"source":{"id":"https://openalex.org/S178647319","display_name":"Microbial Drug Resistance","issn_l":"1076-6294","issn":["1076-6294","1931-8448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Drug Resistance","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055994995","display_name":"Endale T. Mekonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089162","display_name":"Northwestern Memorial Hospital","ror":"https://ror.org/009543z50","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210089162","https://openalex.org/I4210147348"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Endale T. Mekonen","raw_affiliation_strings":["Department of Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA","institution_ids":["https://openalex.org/I4210089162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020381958","display_name":"Gary A. Noskin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary A. Noskin","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007530189","display_name":"Donna M. Hacek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donna M. Hacek","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026183066","display_name":"Lance R. Peterson","orcid":"https://orcid.org/0000-0001-5279-4752","observed_orcids":["https://orcid.org/0000-0001-5279-4752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lance R. Peterson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7552,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.82865169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1","issue":"3","first_page":"249","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9243000149726868,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin-resistant-enterococcus-faecium","display_name":"vancomycin-resistant Enterococcus faecium","score":0.921999990940094},{"id":"https://openalex.org/keywords/persistent-bacteremia","display_name":"persistent bacteremia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/ampicillin-sulbactam","display_name":"ampicillin-sulbactam","score":0.8539999723434448},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/liver-transplant-recipients","display_name":"liver transplant recipients","score":0.847000002861023},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility-interpretation","display_name":"antimicrobial susceptibility interpretation","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2777677444","wikidata":"https://www.wikidata.org/wiki/Q140010","display_name":"Enterococcus faecium","level":3,"score":0.8025035262107849},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7763806581497192},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.7640846967697144},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.7037327885627747},{"id":"https://openalex.org/C183641309","wikidata":"https://www.wikidata.org/wiki/Q306264","display_name":"Amp resistance","level":4,"score":0.6889705657958984},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.5711832046508789},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.52564537525177},{"id":"https://openalex.org/C2780585763","wikidata":"https://www.wikidata.org/wiki/Q517258","display_name":"Enterococcus","level":3,"score":0.5229052901268005},{"id":"https://openalex.org/C2777490607","wikidata":"https://www.wikidata.org/wiki/Q2610066","display_name":"Vancomycin-resistant Enterococcus","level":5,"score":0.517261803150177},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.344083309173584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3128569424152374},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.24653670191764832},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.14765596389770508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000668","descriptor_name":"Ampicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016908","descriptor_name":"Gram-Positive Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016984","descriptor_name":"Enterococcus faecium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048909","descriptor_name":"Diabetes Complications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/mdr.1995.1.249","doi":"https://doi.org/10.1089/mdr.1995.1.249","is_oa":false,"landing_page_url":"https://doi.org/10.1089/mdr.1995.1.249","pdf_url":null,"source":{"id":"https://openalex.org/S178647319","display_name":"Microbial Drug Resistance","issn_l":"1076-6294","issn":["1076-6294","1931-8448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Drug Resistance","raw_type":"journal-article"},{"id":"pmid:9158783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9158783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial drug resistance (Larchmont, N.Y.)","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1965588405","https://openalex.org/W1969398732","https://openalex.org/W1976885209","https://openalex.org/W1988123187","https://openalex.org/W2008726200","https://openalex.org/W2009889907","https://openalex.org/W2012311967","https://openalex.org/W2013402390","https://openalex.org/W2015617625","https://openalex.org/W2015659273","https://openalex.org/W2032879566","https://openalex.org/W2037091330","https://openalex.org/W2053899751","https://openalex.org/W2072749218","https://openalex.org/W2086351130","https://openalex.org/W2096742106","https://openalex.org/W2102876406","https://openalex.org/W2103176803","https://openalex.org/W2104019014","https://openalex.org/W2108715876","https://openalex.org/W2144347018","https://openalex.org/W2164576845","https://openalex.org/W2164997544","https://openalex.org/W2169620427","https://openalex.org/W2405027317","https://openalex.org/W2467210266"],"related_works":["https://openalex.org/W2143662443","https://openalex.org/W2015617625","https://openalex.org/W2039597199","https://openalex.org/W2028364220","https://openalex.org/W1996560444","https://openalex.org/W2147321906","https://openalex.org/W4311543605","https://openalex.org/W2030775317","https://openalex.org/W2052174701","https://openalex.org/W2146956257"],"abstract_inverted_index":{"Emergence":[0],"of":[1,51,75,94,113,122,136,144],"vancomycin-resistant":[2,20],"enterococci":[3],"has":[4],"become":[5],"an":[6,67,84,92],"increasing":[7],"problem":[8],"in":[9,128],"many":[10],"medical":[11],"centers.":[12],"We":[13],"report":[14],"a":[15,142],"liver":[16],"transplant":[17],"recipient":[18],"with":[19],"Enterococcus":[21],"faecium":[22,53],"bacteremia":[23],"who":[24],"was":[25],"successfully":[26],"treated":[27],"using":[28],"very":[29],"high":[30,42],"dose":[31,43],"continuous":[32],"infusion":[33],"ampicillin/sulbactam,":[34],"plus":[35],"gentamicin":[36],"after":[37],"he":[38],"remained":[39],"bacteremic":[40],"on":[41],"ampicillin":[44,65,103,114],"and":[45,125,139,151],"gentamicin.":[46],"At":[47],"our":[48,123],"institution,":[49],"83%":[50],"E.":[52],"isolates":[54],"from":[55],"1994":[56],"were":[57],"inhibited":[58],"by":[59,148,155],"ampicillin/sulbactam":[60,116],"compared":[61],"to":[62,104],"66%":[63],"for":[64,102,133],"at":[66],"MIC":[68,93],"<":[69,95],"or":[70,96,115],"=":[71,97],"64":[72],"micrograms/ml.":[73],"None":[74],"these":[76],"strains":[77],"produced":[78],"beta-lactamase,":[79],"suggesting":[80],"sulbactam":[81],"may":[82,140],"have":[83,131],"unexplained":[85],"beneficial":[86],"effect":[87],"against":[88,108],"some":[89],"enterococci.":[90],"Although":[91],"8":[98],"micrograms/ml":[99],"is":[100],"required":[101],"be":[105],"considered":[106],"active":[107],"enterococci,":[109],"much":[110],"higher":[111],"levels":[112],"are":[117],"safely":[118],"achievable.":[119],"The":[120],"response":[121],"patient":[124],"the":[126],"reported":[127],"vivo":[129],"data":[130],"implications":[132],"future":[134],"treatment":[135],"this":[137],"pathogen,":[138],"necessitate":[141],"reevaluation":[143],"susceptibility":[145],"interpretation":[146],"guidelines":[147],"clinical":[149],"laboratories,":[150],"therapeutic":[152],"drug":[153],"dosing":[154],"clinicians.":[156]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
