{"id":"https://openalex.org/W2007479654","doi":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","title":"Pharmacokinetics of Nadolol in Children with Supraventricular Tachycardia","display_name":"Pharmacokinetics of Nadolol in Children with Supraventricular Tachycardia","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2007479654","doi":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","mag":"2007479654","pmid":"https://pubmed.ncbi.nlm.nih.gov/1474163"},"language":"en","primary_location":{"id":"doi:10.1002/j.1552-4604.1992.tb03805.x","doi":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110039765","display_name":"Ashok V. Mehta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashok V. Mehta","raw_affiliation_strings":["Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0578","Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0578","institution_ids":["https://openalex.org/I119443389"]},{"raw_affiliation_string":"Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063206725","display_name":"Balasubrahmanyam Chidambaram","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Balasubrahmanyam Chidambaram","raw_affiliation_strings":["Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee","institution_ids":["https://openalex.org/I119443389"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042730834","display_name":"Peter J. Rice","orcid":"https://orcid.org/0000-0002-0707-0138","observed_orcids":["https://orcid.org/0000-0002-0707-0138"]},"institutions":[{"id":"https://openalex.org/I119443389","display_name":"East Tennessee State University","ror":"https://ror.org/05rfqv493","country_code":"US","type":"education","lineage":["https://openalex.org/I119443389"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Rice","raw_affiliation_strings":["Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee","institution_ids":["https://openalex.org/I119443389"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110039765"],"corresponding_institution_ids":["https://openalex.org/I119443389"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.11813403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"32","issue":"11","first_page":"1023","last_page":"1027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadolol","display_name":"nadolol","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8980000019073486},{"id":"https://openalex.org/keywords/supraventricular-tachycardia","display_name":"supraventricular tachycardia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6759999990463257},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.9369999766349792},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.878000020980835},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.7429999709129333},{"id":"https://openalex.org/keywords/two-compartment-model","display_name":"two-compartment model","score":0.828000009059906},{"id":"https://openalex.org/keywords/age-differences","display_name":"age differences","score":0.5550000071525574},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.9909999966621399}],"concepts":[{"id":"https://openalex.org/C2776256041","wikidata":"https://www.wikidata.org/wiki/Q424952","display_name":"Nadolol","level":3,"score":0.9932882189750671},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8929134607315063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7390166521072388},{"id":"https://openalex.org/C2776934708","wikidata":"https://www.wikidata.org/wiki/Q1598909","display_name":"Supraventricular tachycardia","level":3,"score":0.7201939821243286},{"id":"https://openalex.org/C2780283014","wikidata":"https://www.wikidata.org/wiki/Q209583","display_name":"Tachycardia","level":2,"score":0.5709458589553833},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4166114330291748},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.41652336716651917},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30380383133888245},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009248","descriptor_name":"Nadolol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D009248","descriptor_name":"Nadolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013617","descriptor_name":"Tachycardia, Supraventricular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013617","descriptor_name":"Tachycardia, Supraventricular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1552-4604.1992.tb03805.x","doi":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1552-4604.1992.tb03805.x","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:1474163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1474163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Comparative Study"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-13821","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/12555","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W152017410","https://openalex.org/W1974047156","https://openalex.org/W1980000380","https://openalex.org/W1980496646","https://openalex.org/W1981199592","https://openalex.org/W1986280529","https://openalex.org/W1988388766","https://openalex.org/W1992580136","https://openalex.org/W1993140285","https://openalex.org/W1998028625","https://openalex.org/W2009516197","https://openalex.org/W2039789426","https://openalex.org/W2051308015","https://openalex.org/W2080335365","https://openalex.org/W2167483353"],"related_works":["https://openalex.org/W2167483353","https://openalex.org/W2565866833","https://openalex.org/W4239833564","https://openalex.org/W4407895322","https://openalex.org/W2079922025","https://openalex.org/W7206902370","https://openalex.org/W2019433087","https://openalex.org/W4293559815","https://openalex.org/W2069648593","https://openalex.org/W1980000380"],"abstract_inverted_index":{"The":[0],"pharmacokinetics":[1,80,96],"of":[2,22,43,103],"intravenous":[3,75],"and":[4],"oral":[5],"nadolol,":[6],"a":[7,82],"long-acting":[8],"beta-adrenoceptor":[9],"blocking":[10],"agent,":[11],"were":[12],"investigated":[13],"in":[14,57,60,68,94,110],"six":[15],"children":[16,38],"receiving":[17],"the":[18,26,100],"drug":[19],"for":[20],"treatment":[21],"supraventricular":[23],"tachycardia.":[24],"In":[25,37],"youngest":[27],"patient":[28],"(age":[29],"3":[30],"months),":[31],"no":[32],"distribution":[33,83],"phase":[34,84],"was":[35],"seen.":[36],"younger":[39],"than":[40,56],"22":[41],"months":[42],"age,":[44],"nadolol":[45,77,95],"is":[46,63],"more":[47,64],"rapidly":[48],"eliminated":[49],"(t1/2":[50,70,85],"=":[51,86],"4.3":[52],"hours":[53],"or":[54],"less)":[55],"older":[58],"children,":[59],"whom":[61],"elimination":[62],"similar":[65],"to":[66],"that":[67],"adults":[69],"approximately":[71],"7.3-15.7":[72],"hours).":[73],"After":[74],"administration,":[76],"displayed":[78],"two-compartment":[79],"with":[81],"0.2-1.1":[87],"hours)":[88],"followed":[89],"by":[90],"elimination.":[91],"Large":[92],"changes":[93],"may":[97],"occur":[98],"during":[99],"first":[101],"year":[102],"life.":[104],"Nadolol":[105],"should":[106],"be":[107],"used":[108],"cautiously":[109],"infants.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
