{"id":"https://openalex.org/W2007477027","doi":"https://doi.org/10.1007/s11064-012-0833-y","title":"Phenelzine (Monoamine Oxidase Inhibitor) Increases Production of Nitric Oxide and Proinflammatory Cytokines via the NF-\u03baB Pathway in Lipopolysaccharide-Activated Microglia Cells","display_name":"Phenelzine (Monoamine Oxidase Inhibitor) Increases Production of Nitric Oxide and Proinflammatory Cytokines via the NF-\u03baB Pathway in Lipopolysaccharide-Activated Microglia Cells","publication_year":2012,"publication_date":"2012-07-04","ids":{"openalex":"https://openalex.org/W2007477027","doi":"https://doi.org/10.1007/s11064-012-0833-y","mag":"2007477027","pmid":"https://pubmed.ncbi.nlm.nih.gov/22763802"},"language":"en","primary_location":{"id":"doi:10.1007/s11064-012-0833-y","doi":"https://doi.org/10.1007/s11064-012-0833-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-012-0833-y","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056367866","display_name":"Hwan\u2010Suck Chung","orcid":"https://orcid.org/0000-0002-5901-0217","observed_orcids":["https://orcid.org/0000-0002-5901-0217"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hwan-Suck Chung","raw_affiliation_strings":["Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102172978","display_name":"Hyunseong Kim","orcid":"https://orcid.org/0009-0008-4161-5876","observed_orcids":["https://orcid.org/0009-0008-4161-5876"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunseong Kim","raw_affiliation_strings":["Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul, 130-701, Republic of Korea","Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul, 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054619950","display_name":"Hyunsu Bae","orcid":"https://orcid.org/0000-0002-0299-3582","observed_orcids":["https://orcid.org/0000-0002-0299-3582"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyunsu Bae","raw_affiliation_strings":["Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul, 130-701, Republic of Korea","Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung Hee University, 1 Hoeki-Dong, Dongdaemoon-gu, Seoul, 130-701, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Physiology, College of Oriental Medicine, Kyung-Hee University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054619950"],"corresponding_institution_ids":["https://openalex.org/I35928602"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":1.0444,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.73390305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"10","first_page":"2117","last_page":"2124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.1665000021457672,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenelzine","display_name":"phenelzine","score":1.0},{"id":"https://openalex.org/keywords/monoamine-oxidase-inhibitors","display_name":"monoamine oxidase inhibitors","score":0.890999972820282},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ikappabalpha-phosphorylation","display_name":"I\u03baB\u03b1 phosphorylation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.5260000228881836},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.972000002861023}],"concepts":[{"id":"https://openalex.org/C2781073023","wikidata":"https://www.wikidata.org/wiki/Q1747559","display_name":"Phenelzine","level":4,"score":0.8943735361099243},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.769921600818634},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6708443760871887},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6414199471473694},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6309487819671631},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.577068567276001},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5675017237663269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49945831298828125},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49662643671035767},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.45124173164367676},{"id":"https://openalex.org/C2777209548","wikidata":"https://www.wikidata.org/wiki/Q414754","display_name":"Apocynin","level":4,"score":0.415108859539032},{"id":"https://openalex.org/C2776024655","wikidata":"https://www.wikidata.org/wiki/Q410867","display_name":"Monoamine oxidase","level":3,"score":0.40782850980758667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3342481255531311},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2946147918701172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.289609432220459},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2819572985172272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2666743993759155},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.24079850316047668},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008996","descriptor_name":"Monoamine Oxidase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010624","descriptor_name":"Phenelzine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018836","descriptor_name":"Inflammation Mediators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11064-012-0833-y","doi":"https://doi.org/10.1007/s11064-012-0833-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s11064-012-0833-y","pdf_url":null,"source":{"id":"https://openalex.org/S174790897","display_name":"Neurochemical Research","issn_l":"0364-3190","issn":["0364-3190","1573-6903"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical Research","raw_type":"journal-article"},{"id":"pmid:22763802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22763802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemical research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W129660925","https://openalex.org/W1520406398","https://openalex.org/W1521338784","https://openalex.org/W1581874091","https://openalex.org/W1822061653","https://openalex.org/W1842054631","https://openalex.org/W1968547119","https://openalex.org/W1971200109","https://openalex.org/W1981408589","https://openalex.org/W1988581380","https://openalex.org/W1991749549","https://openalex.org/W1998689099","https://openalex.org/W1998826441","https://openalex.org/W2000569984","https://openalex.org/W2011361113","https://openalex.org/W2021533801","https://openalex.org/W2022832183","https://openalex.org/W2023170094","https://openalex.org/W2024470090","https://openalex.org/W2036600670","https://openalex.org/W2038434279","https://openalex.org/W2038473038","https://openalex.org/W2041438725","https://openalex.org/W2048325240","https://openalex.org/W2049594815","https://openalex.org/W2052359947","https://openalex.org/W2059918917","https://openalex.org/W2061679510","https://openalex.org/W2078056296","https://openalex.org/W2088071868","https://openalex.org/W2091354890","https://openalex.org/W2099878755","https://openalex.org/W2104412114","https://openalex.org/W2109759840","https://openalex.org/W2116784956","https://openalex.org/W2119958966","https://openalex.org/W2129106427","https://openalex.org/W2149704806","https://openalex.org/W2168911501","https://openalex.org/W2169308131","https://openalex.org/W2324553845","https://openalex.org/W2407284690","https://openalex.org/W2418613038","https://openalex.org/W2504143414","https://openalex.org/W4247673683","https://openalex.org/W4285719527","https://openalex.org/W4313331142","https://openalex.org/W6979169529"],"related_works":["https://openalex.org/W4313349796","https://openalex.org/W1972024575","https://openalex.org/W4313200351","https://openalex.org/W2115563225","https://openalex.org/W2017858885","https://openalex.org/W2158635731","https://openalex.org/W7100968992","https://openalex.org/W3188990772","https://openalex.org/W1987810683","https://openalex.org/W2051284802"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}