{"id":"https://openalex.org/W2007448071","doi":"https://doi.org/10.1097/00005344-199009000-00008","title":"Rate-Dependent Class III Antiarrhythmic Action, Negative Chronotropy, and Positive Inotropy of a Novel Ik Blocking Drug, UK-68,798","display_name":"Rate-Dependent Class III Antiarrhythmic Action, Negative Chronotropy, and Positive Inotropy of a Novel Ik Blocking Drug, UK-68,798","publication_year":1990,"publication_date":"1990-09-01","ids":{"openalex":"https://openalex.org/W2007448071","doi":"https://doi.org/10.1097/00005344-199009000-00008","mag":"2007448071","pmid":"https://pubmed.ncbi.nlm.nih.gov/1700210"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199009000-00008","doi":"https://doi.org/10.1097/00005344-199009000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199009000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112739778","display_name":"P\u00e5l M. Tande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"P\u00e5l M. Tande","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Norway","Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]},{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109949529","display_name":"Hanne Bj\u00f8rnstad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Hanne Bj\u00f8rnstad","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100780756","display_name":"Tao Yang","orcid":"https://orcid.org/0000-0003-1472-7051","observed_orcids":["https://orcid.org/0000-0003-1472-7051"]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Tao Yang","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111711249","display_name":"Helge Refsum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Helge Refsum","raw_affiliation_strings":["Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physiology, Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78037679"],"apc_list":null,"apc_paid":null,"fwci":11.7282,"has_fulltext":false,"cited_by_count":178,"citation_normalized_percentile":{"value":0.98882724,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"401","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/class-iii-antiarrhythmic-drugs","display_name":"class III antiarrhythmic agents","score":0.9440000057220459},{"id":"https://openalex.org/keywords/delayed-rectifier-potassium-current","display_name":"delayed rectifier potassium current","score":0.8830000162124634},{"id":"https://openalex.org/keywords/negative-chronotropic-effect","display_name":"negative chronotropic effect","score":0.972000002861023},{"id":"https://openalex.org/keywords/positive-inotropic-effect","display_name":"positive inotropic effect","score":0.9940000176429749},{"id":"https://openalex.org/keywords/action-potential-duration-prolongation","display_name":"action potential duration prolongation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/effective-refractory-period","display_name":"effective refractory period","score":0.9539999961853027},{"id":"https://openalex.org/keywords/early-afterdepolarizations","display_name":"early afterdepolarizations","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.7990000247955322},{"id":"https://openalex.org/keywords/sinus-node-recovery-time","display_name":"sinus node recovery time","score":0.9279999732971191},{"id":"https://openalex.org/keywords/d-sotalol","display_name":"d-sotalol","score":0.6790000200271606},{"id":"https://openalex.org/keywords/papillary-muscle-contractility","display_name":"papillary muscle contractility","score":0.7049999833106995},{"id":"https://openalex.org/keywords/arrhythmogenic-potential","display_name":"arrhythmogenic potential","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C155730078","wikidata":"https://www.wikidata.org/wiki/Q2898697","display_name":"Afterdepolarization","level":4,"score":0.7872181534767151},{"id":"https://openalex.org/C189327125","wikidata":"https://www.wikidata.org/wiki/Q5347276","display_name":"Effective refractory period","level":3,"score":0.6459617614746094},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5417668223381042},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.5241665840148926},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.5211862921714783},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5158776044845581},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5076476335525513},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.473320335149765},{"id":"https://openalex.org/C2910096629","wikidata":"https://www.wikidata.org/wiki/Q241549","display_name":"Anti-Arrhythmia Agents","level":3,"score":0.45121338963508606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4248027205467224},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4152362048625946},{"id":"https://openalex.org/C158328960","wikidata":"https://www.wikidata.org/wiki/Q1088369","display_name":"Chronotropic","level":4,"score":0.4116651117801666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4069204330444336},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34361356496810913},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.29031747579574585},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.27685433626174927},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.10419988632202148},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010210","descriptor_name":"Papillary Muscles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010627","descriptor_name":"Phenethylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013015","descriptor_name":"Sotalol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013268","descriptor_name":"Stimulation, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015222","descriptor_name":"Sodium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199009000-00008","doi":"https://doi.org/10.1097/00005344-199009000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199009000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:1700210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1700210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2142650001","https://openalex.org/W1970906303","https://openalex.org/W1857240286","https://openalex.org/W2016275322","https://openalex.org/W1982582485","https://openalex.org/W2921642870","https://openalex.org/W2022627207","https://openalex.org/W2254921239","https://openalex.org/W4214674245","https://openalex.org/W7096151110"],"abstract_inverted_index":{"The":[0],"electromechanical":[1],"effects":[2,93,162],"of":[3,55,119,130,156,176,198,209],"UK-68,798":[4,199],"(UK),":[5],"a":[6,173,189,213],"novel":[7],"class":[8,194],"III":[9,195],"antiarrhythmic":[10,196],"drug,":[11],"were":[12],"studied":[13],"in":[14,24,45,57,117],"guinea":[15,58,157],"pig":[16,59,158],"and":[17,22,41,110,149,191,207],"rat":[18,164],"papillary":[19],"muscles":[20],"(PMs)":[21],"atria":[23],"vitro":[25],"using":[26],"conventional":[27],"microelectrode":[28],"technique.":[29],"UK":[30,65,98,141,177],"(10(-8)-10(-6)":[31],"M)":[32,143],"prolonged":[33,99,150],"the":[34,49,67,72,90,100,145,151,179],"action":[35,175,197],"potential":[36,51,214],"duration":[37],"(APD)":[38],"by":[39],"21-58%":[40],"effective":[42],"refractory":[43],"period":[44],"parallel,":[46],"without":[47,70],"affecting":[48],"resting":[50],"or":[52,77,166],"maximum":[53],"rate":[54,148],"depolarization":[56],"PM":[60,165],"stimulated":[61],"at":[62,104,108,125],"1":[63,109],"Hz.":[64,112,127],"increased":[66],"contractile":[68],"force":[69,76],"prolonging":[71],"time":[73,155],"to":[74,88,137],"peak":[75],"relaxation.":[78],"In":[79],"comparison,":[80],"5":[81],"x":[82],"10(-5)":[83,170],"M":[84,96,124],"d-sotalol":[85],"was":[86,133],"needed":[87],"induce":[89],"same":[91],"electrophysiological":[92],"as":[94],"10(-8)":[95],"UK.":[97],"APD":[101],"significantly":[102],"less":[103],"2":[105,118,138],"Hz":[106],"than":[107],"0.5":[111,126],"Early":[113],"afterdepolarizations":[114],"(EADs)":[115],"developed":[116],"11":[120],"preparations":[121],"after":[122,135,169],"10(-6)":[123],"No":[128,161],"reversal":[129],"drug":[131],"effect":[132],"seen":[134],"up":[136],"h":[139],"washout.":[140],"(10(-9)-10(-5)":[142],"reduced":[144],"spontaneous":[146],"heart":[147],"sinus":[152],"node":[153],"recovery":[154],"right":[159],"atria.":[160],"on":[163,178],"atria,":[167],"even":[168],"M,":[171],"indicate":[172,188],"selective":[174],"delayed":[180],"rectifying":[181],"outward":[182],"potassium":[183],"current,":[184],"Ik.":[185],"These":[186],"results":[187],"potent":[190],"selective,":[192],"rate-dependent":[193],"linked":[200],"with":[201],"positive":[202],"inotropy.":[203],"Increased":[204],"APD,":[205],"bradycardia,":[206],"induction":[208],"EADs,":[210],"however,":[211],"represent":[212],"arrhythmogenic":[215],"combination.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
