{"id":"https://openalex.org/W2007447671","doi":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","title":"Neurophysiological Effects ofEuphorbia hirta L. (Euphorbiaceae)","display_name":"Neurophysiological Effects ofEuphorbia hirta L. (Euphorbiaceae)","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2007447671","doi":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","mag":"2007447671"},"language":"es","primary_location":{"id":"doi:10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","doi":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107446755","display_name":"Marie\u2010Claire Lanhers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264217","display_name":"Universit\u00e9 Henri Poincar\u00e9","ror":"https://ror.org/019wrwh65","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405264217","https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"M. C. Lanhers","raw_affiliation_strings":["Laboratoire de Chimie Ge\u0301ne\u0301rale applique\u0301e a\u0300 la Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 Nancy I, B. P. 184-F-54505 Vandoeuvre, France","Laboratoire de Chimie G\u00e9n\u00e9rale appliqu\u00e9e \u00e0 la M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Nancy I, B. P. 184\u2010F\u201054505 Vandoeuvre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Chimie Ge\u0301ne\u0301rale applique\u0301e a\u0300 la Me\u0301decine, Faculte\u0301 de Me\u0301decine, Universite\u0301 Nancy I, B. P. 184-F-54505 Vandoeuvre, France","institution_ids":["https://openalex.org/I4405264217"]},{"raw_affiliation_string":"Laboratoire de Chimie G\u00e9n\u00e9rale appliqu\u00e9e \u00e0 la M\u00e9decine, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Nancy I, B. P. 184\u2010F\u201054505 Vandoeuvre, France","institution_ids":["https://openalex.org/I4405264217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045676103","display_name":"Jacques Fleurentin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264049","display_name":"Universit\u00e9 Paul Verlaine - Metz","ror":"https://ror.org/00t8qmx52","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405264049","https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J. Fleurentin","raw_affiliation_strings":["Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Universite\u0301 de Metz, 1 rue des Re\u0301collets - F - 57000 Metz, France","Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Universit\u00e9 de Metz, 1 rue des R\u00e9collets - F - 57000 Metz, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Universite\u0301 de Metz, 1 rue des Re\u0301collets - F - 57000 Metz, France","institution_ids":["https://openalex.org/I4405264049"]},{"raw_affiliation_string":"Laboratoire de Pharmacognosie, Centre des Sciences de l'Environnement, Universit\u00e9 de Metz, 1 rue des R\u00e9collets - F - 57000 Metz, France","institution_ids":["https://openalex.org/I4405264049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049116894","display_name":"Pierre Dorfman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Dorfman","raw_affiliation_strings":["Laboratoires Dolisos, 71 rue Beaubourg - F - 75003 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoires Dolisos, 71 rue Beaubourg - F - 75003 Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113633727","display_name":"Ren\u00e9 Misslin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Misslin","raw_affiliation_strings":[";Laboratoire de Psychopharmacologie, Universite\u0301 L. Pasteur, 7 rue de l'Universite\u0301-F - 67000 Strasbourg, France",";Laboratoire de Psychopharmacologie, Universit\u00e9 L. Pasteur, 7 rue de l'Universit\u00e9\u2010F \u2010 67000 Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":";Laboratoire de Psychopharmacologie, Universite\u0301 L. Pasteur, 7 rue de l'Universite\u0301-F - 67000 Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]},{"raw_affiliation_string":";Laboratoire de Psychopharmacologie, Universit\u00e9 L. Pasteur, 7 rue de l'Universit\u00e9\u2010F \u2010 67000 Strasbourg, France","institution_ids":["https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034460742","display_name":"Fran\u00e7ois Mortier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Mortier","raw_affiliation_strings":["Laboratoire de Pharmacognosie, Universite\u0301 Nancy I, B.P. 403, 5 rue Albert Lebrun - F - 54001 Nancy Ce\u0301dex, France","Laboratoire de Pharmacognosie, Universit\u00e9 Nancy I, B.P. 403, 5 rue Albert Lebrun \u2010 F \u2010 54001 Nancy C\u00e9dex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Pharmacognosie, Universite\u0301 Nancy I, B.P. 403, 5 rue Albert Lebrun - F - 54001 Nancy Ce\u0301dex, France","institution_ids":[]},{"raw_affiliation_string":"Laboratoire de Pharmacognosie, Universit\u00e9 Nancy I, B.P. 403, 5 rue Albert Lebrun \u2010 F \u2010 54001 Nancy C\u00e9dex, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5107446755"],"corresponding_institution_ids":["https://openalex.org/I4405264217"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.32751092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"10","issue":"8","first_page":"670","last_page":"676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/euphorbia-hirta","display_name":"Euphorbia hirta","score":1.0},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hypnotic-effects","display_name":"hypnotic effects","score":0.7889999747276306},{"id":"https://openalex.org/keywords/neuroleptic-activity","display_name":"neuroleptic activity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.9269999861717224},{"id":"https://openalex.org/keywords/sedative-effects","display_name":"sedative effects","score":0.6600000262260437},{"id":"https://openalex.org/keywords/analgesic-effect","display_name":"analgesic effect","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pentylenetetrazole","display_name":"pentylenetetrazole","score":0.7850000262260437},{"id":"https://openalex.org/keywords/barbiturate-potentiation","display_name":"barbiturate potentiation","score":0.8479999899864197},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7313267588615417},{"id":"https://openalex.org/C2776819090","wikidata":"https://www.wikidata.org/wiki/Q412391","display_name":"Pentylenetetrazol","level":4,"score":0.7017514109611511},{"id":"https://openalex.org/C2776860028","wikidata":"https://www.wikidata.org/wiki/Q1225289","display_name":"Muscle relaxant","level":2,"score":0.678325891494751},{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.6005333662033081},{"id":"https://openalex.org/C2778900099","wikidata":"https://www.wikidata.org/wiki/Q5166679","display_name":"Convulsant","level":3,"score":0.5630720257759094},{"id":"https://openalex.org/C2779047212","wikidata":"https://www.wikidata.org/wiki/Q156584","display_name":"Euphorbiaceae","level":2,"score":0.5231467485427856},{"id":"https://openalex.org/C2778824757","wikidata":"https://www.wikidata.org/wiki/Q676896","display_name":"Oxotremorine","level":4,"score":0.5079558491706848},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5034446120262146},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.47995856404304504},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.45886749029159546},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.448001503944397},{"id":"https://openalex.org/C2777602617","wikidata":"https://www.wikidata.org/wiki/Q847705","display_name":"Sedative","level":2,"score":0.44745439291000366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.309561550617218},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.27064061164855957},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2688010036945343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26596951484680176},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.25255557894706726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11795875430107117},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09486767649650574},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0940919816493988},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","doi":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-1573(199612)10:8<670::aid-ptr934>3.0.co;2-6","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2133253032","https://openalex.org/W7099874971","https://openalex.org/W1994394231","https://openalex.org/W2951246041","https://openalex.org/W7118226693","https://openalex.org/W2620005562","https://openalex.org/W589134652","https://openalex.org/W3203891288","https://openalex.org/W7008712611","https://openalex.org/W6999417418"],"abstract_inverted_index":{"A":[0],"lyophilized":[1],"aqueous":[2,97],"extract":[3,38,98],"of":[4,28,47,84],"Euphorbia":[5],"hirta":[6],"L.":[7],"(Eh)":[8],"has":[9],"been":[10],"evaluated":[11],"for":[12,16,65],"benzodiazepine-like":[13],"properties":[14],"and":[15,19,31,56,86,113],"hypnotic,":[17],"neuroleptic":[18,102],"antidepressant":[20,106],"properties,":[21],"in":[22,78],"order":[23],"to":[24,61],"complete":[25],"the":[26,44,92],"study":[27],"dose-dependent":[29],"sedative":[30],"analgesic":[32],"effects":[33,46,55,77,107],"previously":[34],"demonstrated.":[35],"The":[36],"plant":[37],"did":[39,50,58,71,99],"not":[40,51,59,72,100],"protect":[41],"mice":[42],"against":[43,110],"convulsant":[45],"pentylenetetrazol,":[48],"it":[49,57,81],"cause":[52],"muscle":[53],"relaxant":[54],"seem":[60],"possess":[62,101],"any":[63],"affinity":[64],"benzodiazepine":[66],"receptors.":[67],"In":[68],"addition,":[69],"Eh":[70],"have":[73],"its":[74],"own":[75],"hypnotic":[76],"mice,":[79],"but":[80,104],"intensified":[82],"those":[83],"barbiturates,":[85],"caused":[87],"a":[88],"direct":[89],"action":[90],"on":[91],"central":[93],"nervous":[94],"system.":[95],"This":[96],"activity,":[103],"slight":[105],"were":[108],"obtained":[109],"reserpine-induced":[111],"ptosis":[112],"oxotremorine-induced":[114],"hypothermia.":[115]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}