{"id":"https://openalex.org/W2007444380","doi":"https://doi.org/10.1055/s-0035-1545696","title":"Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies","display_name":"Protective Effect of Tetrahydrocurcumin against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies","publication_year":2015,"publication_date":"2015-02-26","ids":{"openalex":"https://openalex.org/W2007444380","doi":"https://doi.org/10.1055/s-0035-1545696","mag":"2007444380","pmid":"https://pubmed.ncbi.nlm.nih.gov/25719941"},"language":"en","primary_location":{"id":"doi:10.1055/s-0035-1545696","doi":"https://doi.org/10.1055/s-0035-1545696","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0035-1545696","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0035-1545696.pdf","source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0035-1545696.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082812257","display_name":"Kyung Il Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210139505","display_name":"Gangneung Asan Hospital","ror":"https://ror.org/03pw3x387","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210139505","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung Song","raw_affiliation_strings":["Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210139505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051549679","display_name":"Jun Tae Park","orcid":"https://orcid.org/0000-0002-7873-1458","observed_orcids":["https://orcid.org/0000-0002-7873-1458"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Park","raw_affiliation_strings":["College of Korean Medicine, Gachon University, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Gachon University, Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001712391","display_name":"Seungyong Lee","orcid":"https://orcid.org/0000-0002-5397-6889","observed_orcids":["https://orcid.org/0000-0002-5397-6889"]},"institutions":[{"id":"https://openalex.org/I151811957","display_name":"Gyeongnam National University of Science and Technology","ror":"https://ror.org/059r50h13","country_code":"KR","type":"education","lineage":["https://openalex.org/I151811957"]},{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyong Lee","raw_affiliation_strings":["Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea","Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea","institution_ids":["https://openalex.org/I58716616"]},{"raw_affiliation_string":"Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea","institution_ids":["https://openalex.org/I151811957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101993609","display_name":"Dahae Lee","orcid":"https://orcid.org/0000-0003-2180-5871","observed_orcids":["https://orcid.org/0000-0003-2180-5871"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]},{"id":"https://openalex.org/I151811957","display_name":"Gyeongnam National University of Science and Technology","ror":"https://ror.org/059r50h13","country_code":"KR","type":"education","lineage":["https://openalex.org/I151811957"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dahae Lee","raw_affiliation_strings":["College of Korean Medicine, Gachon University, Seongnam, Korea","Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Gachon University, Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]},{"raw_affiliation_string":"Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea","institution_ids":["https://openalex.org/I151811957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103490530","display_name":"Hyuk-Jai Jang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]},{"id":"https://openalex.org/I4210139505","display_name":"Gangneung Asan Hospital","ror":"https://ror.org/03pw3x387","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210139505","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyuk-Jai Jang","raw_affiliation_strings":["Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, Korea","institution_ids":["https://openalex.org/I40542001","https://openalex.org/I4210139505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023313352","display_name":"Su\u2010Nam Kim","orcid":"https://orcid.org/0000-0003-3218-4521","observed_orcids":["https://orcid.org/0000-0003-3218-4521"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Su-Nam Kim","raw_affiliation_strings":["Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004982205","display_name":"Hyeonseok Ko","orcid":"https://orcid.org/0000-0002-5045-564X","observed_orcids":["https://orcid.org/0000-0002-5045-564X"]},"institutions":[{"id":"https://openalex.org/I4210163218","display_name":"Cheil General Hospital and Women's Healthcare Center","ror":"https://ror.org/05vxnmp88","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210163218"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeonseok Ko","raw_affiliation_strings":["Laboratory of Molecular Oncology, Cheil General Hospital & Women\u02bcs Healthcare Center, Kwandong University College of Medicine, Seoul, Korea","Laboratory of Molecular Oncology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Oncology, Cheil General Hospital & Women\u02bcs Healthcare Center, Kwandong University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210163218"]},{"raw_affiliation_string":"Laboratory of Molecular Oncology, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea","institution_ids":["https://openalex.org/I4210163218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085850254","display_name":"Hyun Joong Kim","orcid":"https://orcid.org/0000-0002-4935-6353","observed_orcids":["https://orcid.org/0000-0002-4935-6353","https://orcid.org/0009-0009-9259-0637"]},"institutions":[{"id":"https://openalex.org/I151811957","display_name":"Gyeongnam National University of Science and Technology","ror":"https://ror.org/059r50h13","country_code":"KR","type":"education","lineage":["https://openalex.org/I151811957"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyun Kim","raw_affiliation_strings":["Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, Korea","institution_ids":["https://openalex.org/I151811957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053969577","display_name":"Jae Yeol Lee","orcid":"https://orcid.org/0000-0001-6622-6692","observed_orcids":["https://orcid.org/0000-0001-6622-6692"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Lee","raw_affiliation_strings":["Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Institute, Korea Institute of Science and Technology, Gangneung, Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103882360","display_name":"Gwi Seo Hwang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Gwi Hwang","raw_affiliation_strings":["College of Korean Medicine, Gachon University, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Gachon University, Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034078083","display_name":"Ki Sung Kang","orcid":"https://orcid.org/0000-0003-2050-5244","observed_orcids":["https://orcid.org/0000-0003-2050-5244"]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ki Kang","raw_affiliation_strings":["College of Korean Medicine, Gachon University, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Gachon University, Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111908888","display_name":"Noriko Yamabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12832649","display_name":"Gachon University","ror":"https://ror.org/03ryywt80","country_code":"KR","type":"education","lineage":["https://openalex.org/I12832649"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Noriko Yamabe","raw_affiliation_strings":["College of Korean Medicine, Gachon University, Seongnam, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Korean Medicine, Gachon University, Seongnam, Korea","institution_ids":["https://openalex.org/I12832649"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.5339,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.97412222,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"81","issue":"04","first_page":"286","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrocurcumin","display_name":"tetrahydrocurcumin","score":1.0},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.7730000019073486},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9829999804496765},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/llc-pk1-cells","display_name":"LLC-PK1 cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8529999852180481},{"id":"https://openalex.org/keywords/curcumin-derivatives","display_name":"curcumin derivatives","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8117433786392212},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7853965163230896},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7593643069267273},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6370925307273865},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5764884352684021},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5397994518280029},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5019712448120117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49178770184516907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34253180027008057},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2022518813610077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19807645678520203},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1706545650959015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1316165328025818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12895739078521729},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018374","descriptor_name":"LLC-PK1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D030024","descriptor_name":"Curcuma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-0035-1545696","doi":"https://doi.org/10.1055/s-0035-1545696","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0035-1545696","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0035-1545696.pdf","source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},{"id":"pmid:25719941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25719941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta medica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1055/s-0035-1545696","doi":"https://doi.org/10.1055/s-0035-1545696","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0035-1545696","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0035-1545696.pdf","source":{"id":"https://openalex.org/S39653451","display_name":"Planta Medica","issn_l":"0032-0943","issn":["0032-0943","1439-0221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Planta Medica","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007444380.pdf","grobid_xml":"https://content.openalex.org/works/W2007444380.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1939012534","https://openalex.org/W1942214720","https://openalex.org/W1983338915","https://openalex.org/W1983965827","https://openalex.org/W2003392863","https://openalex.org/W2006605504","https://openalex.org/W2016318035","https://openalex.org/W2025687194","https://openalex.org/W2032300767","https://openalex.org/W2043912019","https://openalex.org/W2045458615","https://openalex.org/W2053499907","https://openalex.org/W2058553476","https://openalex.org/W2059190124","https://openalex.org/W2078032630","https://openalex.org/W2087664337","https://openalex.org/W2092856484","https://openalex.org/W2095864077","https://openalex.org/W2099023764","https://openalex.org/W2099252920","https://openalex.org/W2104922276","https://openalex.org/W2108689091","https://openalex.org/W2111665023","https://openalex.org/W2123284347","https://openalex.org/W2135085072","https://openalex.org/W2136341559","https://openalex.org/W2138323164","https://openalex.org/W2142693924","https://openalex.org/W2145194160","https://openalex.org/W2151300092","https://openalex.org/W2153839860","https://openalex.org/W2170326611","https://openalex.org/W2937895527","https://openalex.org/W4250210754"],"related_works":["https://openalex.org/W2811162243","https://openalex.org/W2534857447","https://openalex.org/W2047236160","https://openalex.org/W1984384126","https://openalex.org/W3009025686","https://openalex.org/W7220436203","https://openalex.org/W2592540981","https://openalex.org/W2806887968","https://openalex.org/W4416787405","https://openalex.org/W4410527642"],"abstract_inverted_index":{"The":[0,134],"adverse":[1],"effects":[2,162],"of":[3,27,34,53,86,106,118,141,156],"anticancer":[4],"drugs":[5],"can":[6],"prompt":[7],"patients":[8],"to":[9,23,39,63,151],"end":[10],"their":[11],"treatment":[12],"despite":[13],"the":[14,43,48,83],"efficacy.":[15],"Cisplatin":[16],"is":[17,36],"a":[18,104,115],"platinum-based":[19],"molecule":[20],"widely":[21],"used":[22],"treat":[24],"various":[25],"forms":[26],"cancer,":[28],"but":[29],"frequent":[30],"and":[31,51,61,114,173,190],"long-term":[32],"use":[33,67],"cisplatin":[35,119],"limited":[37],"due":[38],"severe":[40],"nephrotoxicity.":[41],"In":[42],"present":[44],"study,":[45],"we":[46],"investigated":[47,94],"protective":[49,84,161],"effect":[50,85],"mechanism":[52],"tetrahydrocurcumin":[54,80,87,159,183],"on":[55,88,131],"cisplatin-induced":[56,89,164],"kidney":[57],"damage,":[58],"oxidative":[59,90,165],"stress,":[60],"inflammation":[62,189],"evaluate":[64],"its":[65],"possible":[66],"in":[68,95,127,144,168],"renal":[69,73,91,142,166,185],"damage.":[70],"Cisplatin-induced":[71],"LLC-PK1":[72],"cell":[74],"damage":[75,92,167,186],"was":[76,93,98,120],"significantly":[77],"reduced":[78],"by":[79,170,187],"treatment.":[81],"Additionally,":[82],"rats.":[96],"Tetrahydrocurcumin":[97],"orally":[99],"administered":[100,121],"every":[101],"day":[102,132],"at":[103],"dose":[105,117],"80":[107],"mg/kg":[108,124],"body":[109,125],"weight":[110],"for":[111],"ten":[112],"days,":[113],"single":[116],"intraperitoneally":[122],"(7.5":[123],"weight)":[126],"0.9":[128],"%":[129],"saline":[130],"four.":[133],"creatinine":[135],"clearance":[136],"levels,":[137],"which":[138],"were":[139,147],"markers":[140],"dysfunction,":[143],"cisplatin-treated":[145],"rats":[146,169],"recovered":[148],"nearly":[149],"back":[150],"normal":[152],"levels":[153],"after":[154],"administration":[155],"tetrahydrocurcumin.":[157],"Moreover,":[158],"exhibited":[160],"against":[163],"inhibiting":[171],"cyclooxygenase-2":[172],"caspase-3":[174],"activation.":[175],"These":[176],"results":[177],"collectively":[178],"provide":[179],"therapeutic":[180],"evidence":[181],"that":[182],"ameliorates":[184],"regulating":[188],"apoptosis.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}