{"id":"https://openalex.org/W2007441754","doi":"https://doi.org/10.1074/jbc.m509293200","title":"p53 Mediates the Accelerated Onset of Senescence of Endothelial Progenitor Cells in Diabetes","display_name":"p53 Mediates the Accelerated Onset of Senescence of Endothelial Progenitor Cells in Diabetes","publication_year":2005,"publication_date":"2005-12-10","ids":{"openalex":"https://openalex.org/W2007441754","doi":"https://doi.org/10.1074/jbc.m509293200","mag":"2007441754","pmid":"https://pubmed.ncbi.nlm.nih.gov/16339764"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m509293200","doi":"https://doi.org/10.1074/jbc.m509293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m509293200","pdf_url":"http://www.jbc.org/article/S0021925819484202/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819484202/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113770386","display_name":"Arturo Rosso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Arturo Rosso","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Italy","Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090129368","display_name":"Antonina Balsamo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonina Balsamo","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022045437","display_name":"Roberto Gambino","orcid":"https://orcid.org/0000-0003-1902-3627","observed_orcids":["https://orcid.org/0000-0003-1902-3627"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Gambino","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000476200","display_name":"Patrizia Dentelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Patrizia Dentelli","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067282968","display_name":"Rita Falcioni","orcid":"https://orcid.org/0000-0002-3745-4327","observed_orcids":["https://orcid.org/0000-0002-3745-4327"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rita Falcioni","raw_affiliation_strings":["Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncogenesis Laboratory, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, 00158 Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060083972","display_name":"Maurizio Cassader","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Cassader","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014845305","display_name":"Luigi Pegoraro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Pegoraro","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111837905","display_name":"Gianfranco Pagano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianfranco Pagano","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090995256","display_name":"Maria Felice Brizzi","orcid":"https://orcid.org/0000-0003-0944-6992","observed_orcids":["https://orcid.org/0000-0003-0944-6992"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Felice Brizzi","raw_affiliation_strings":["Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Torino, Corso Dogliotti 14, 10126 Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090995256"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.938,"has_fulltext":true,"cited_by_count":150,"citation_normalized_percentile":{"value":0.83836873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"281","issue":"7","first_page":"4339","last_page":"4347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.968999981880188},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.8050000071525574},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8149999976158142},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinoblastoma-protein","display_name":"retinoblastoma protein","score":0.9660000205039978},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6629999876022339},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.8949999809265137},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.838067889213562},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6787363290786743},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6095532178878784},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.5737756490707397},{"id":"https://openalex.org/C2780152582","wikidata":"https://www.wikidata.org/wiki/Q1340830","display_name":"Endothelial progenitor cell","level":4,"score":0.47847673296928406},{"id":"https://openalex.org/C2779523775","wikidata":"https://www.wikidata.org/wiki/Q9075999","display_name":"Cellular senescence","level":4,"score":0.45782431960105896},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43149271607398987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36888471245765686},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36657580733299255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34217965602874756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.328734815120697},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2974129319190979},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.22282743453979492},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16482433676719666},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.06918472051620483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0466366708278656}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m509293200","doi":"https://doi.org/10.1074/jbc.m509293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m509293200","pdf_url":"http://www.jbc.org/article/S0021925819484202/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16339764","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16339764","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/39441","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/39441","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:zenodo.org:95595","doi":null,"is_oa":true,"landing_page_url":"https://www.openaccessrepository.it/record/95595","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m509293200","doi":"https://doi.org/10.1074/jbc.m509293200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m509293200","pdf_url":"http://www.jbc.org/article/S0021925819484202/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007441754.pdf","grobid_xml":"https://content.openalex.org/works/W2007441754.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W165254100","https://openalex.org/W182888219","https://openalex.org/W1523325879","https://openalex.org/W1606722513","https://openalex.org/W1973570584","https://openalex.org/W1975173778","https://openalex.org/W1979648945","https://openalex.org/W1987430295","https://openalex.org/W1989378631","https://openalex.org/W1992934869","https://openalex.org/W1995928382","https://openalex.org/W2013529909","https://openalex.org/W2022572059","https://openalex.org/W2023973783","https://openalex.org/W2024209230","https://openalex.org/W2024619097","https://openalex.org/W2030535042","https://openalex.org/W2030963645","https://openalex.org/W2034577150","https://openalex.org/W2036676765","https://openalex.org/W2038783205","https://openalex.org/W2043725160","https://openalex.org/W2049035024","https://openalex.org/W2050551830","https://openalex.org/W2052244692","https://openalex.org/W2061619522","https://openalex.org/W2071161576","https://openalex.org/W2084608852","https://openalex.org/W2085593164","https://openalex.org/W2098995242","https://openalex.org/W2103412023","https://openalex.org/W2104576349","https://openalex.org/W2104908670","https://openalex.org/W2105389665","https://openalex.org/W2111450457","https://openalex.org/W2113879453","https://openalex.org/W2115337518","https://openalex.org/W2115950020","https://openalex.org/W2116177188","https://openalex.org/W2116223906","https://openalex.org/W2117620434","https://openalex.org/W2121739926","https://openalex.org/W2127872440","https://openalex.org/W2127923665","https://openalex.org/W2134812217","https://openalex.org/W2137570167","https://openalex.org/W2142041241","https://openalex.org/W2156863555","https://openalex.org/W2157884715","https://openalex.org/W2158713934","https://openalex.org/W2162462798","https://openalex.org/W2166130989","https://openalex.org/W2166146113","https://openalex.org/W2167290692","https://openalex.org/W2414816141"],"related_works":["https://openalex.org/W2612654481","https://openalex.org/W4247452265","https://openalex.org/W2621727428","https://openalex.org/W2134403068","https://openalex.org/W4392612022","https://openalex.org/W2067349642","https://openalex.org/W2950523123","https://openalex.org/W2918085071","https://openalex.org/W2145805076","https://openalex.org/W2744983753"],"abstract_inverted_index":{"Adverse":[0],"metabolic":[1],"factors,":[2],"including":[3],"oxidized":[4],"small":[5,88],"and":[6,18,68,72,110,136],"dense":[7],"low":[8],"density":[9],"lipoprotein":[10],"(ox-dmLDL)":[11],"can":[12,161],"contribute":[13,162],"to":[14,53,102,133,140,163],"the":[15,19,32,43,93,106,138,149,152,164],"reduced":[16,75],"number":[17],"impaired":[20,165],"functions":[21],"of":[22,45,83,95,105,113,127,151],"circulating":[23],"endothelial":[24],"progenitors":[25],"(EPC)":[26],"in":[27,42,118,144,167],"diabetic":[28,121,124],"patients.":[29,122],"To":[30],"elucidate":[31],"molecular":[33],"mechanisms":[34],"involved,":[35],"EPC":[36,51,119,125],"from":[37,120],"normal":[38],"donors":[39],"were":[40],"cultured":[41],"presence":[44],"ox-dmLDL.":[46],"Under":[47],"these":[48],"experimental":[49],"conditions":[50],"undergo":[52,132],"senescent-like":[54],"growth":[55],"arrest.":[56],"This":[57],"effect":[58,77],"is":[59,98],"associated":[60],"with":[61,73],"Akt":[62],"activation,":[63],"p21":[64],"expression,":[65],"p53":[66,85,129,153],"accumulation,":[67],"retinoblastoma":[69],"protein":[70],"dephosphorylation":[71],"a":[74,157],"protective":[76],"against":[78],"oxidative":[79],"damage.":[80],"Moreover,":[81],"depletion":[82],"endogenous":[84,128],"expression":[86],"by":[87],"interfering":[89],"RNA":[90],"demonstrates":[91],"that":[92,160],"integrity":[94],"this":[96],"pathway":[97,109,155],"essential":[99],"for":[100],"senescence":[101,114],"occur.":[103],"Activation":[104],"Akt/p53/p21":[107],"signaling":[108,154],"accelerated":[111],"onset":[112],"are":[115],"also":[116],"detectable":[117],"Finally,":[123],"depleted":[126],"do":[130],"not":[131],"senescence-growth":[134],"arrest":[135],"acquire":[137],"ability":[139],"form":[141],"tube-like":[142],"structures":[143],"vitro.":[145],"These":[146],"observations":[147],"identify":[148],"activation":[150],"as":[156],"crucial":[158],"event":[159],"neovascularization":[166],"diabetes.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
