{"id":"https://openalex.org/W2007406273","doi":"https://doi.org/10.1159/000051094","title":"Influence of Type II Diabetes on Arterial Tone and Endothelial Function in Murine Mesenteric Resistance Arteries","display_name":"Influence of Type II Diabetes on Arterial Tone and Endothelial Function in Murine Mesenteric Resistance Arteries","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2007406273","doi":"https://doi.org/10.1159/000051094","mag":"2007406273","pmid":"https://pubmed.ncbi.nlm.nih.gov/11740157"},"language":"en","primary_location":{"id":"doi:10.1159/000051094","doi":"https://doi.org/10.1159/000051094","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000051094","pdf_url":null,"source":{"id":"https://openalex.org/S150425866","display_name":"Journal of Vascular Research","issn_l":"1018-1172","issn":["1018-1172","1423-0135"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042299054","display_name":"Guy Lagaud","orcid":"https://orcid.org/0000-0002-4456-9317","observed_orcids":["https://orcid.org/0000-0002-4456-9317"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G.J.L. Lagaud","raw_affiliation_strings":["Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital, Vancouver, Canada. glagaud@aecom.yu.edu","Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital, Vancouver, Canada. glagaud@aecom.yu.edu","institution_ids":["https://openalex.org/I2801362399"]},{"raw_affiliation_string":"Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038365893","display_name":"Esther Masih\u2010Khan","orcid":"https://orcid.org/0000-0002-7271-0680","observed_orcids":["https://orcid.org/0000-0002-7271-0680"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E. Masih-Khan","raw_affiliation_strings":["Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Kai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. Kai","raw_affiliation_strings":["Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112807992","display_name":"Cornells van Breemen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I2801362399","display_name":"St. Paul's Hospital","ror":"https://ror.org/00wzdr059","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801362399"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. van Breemen","raw_affiliation_strings":["Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vancouver Vascular Biology Research Centre, Department of Cardiovascular Research, St. Paul's Hospital and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I2801362399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110162075","display_name":"Gregory P. Dub\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.P. Dub\u00e9","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Ind., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Ind., USA","institution_ids":["https://openalex.org/I168537998"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6733,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.80837479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"6","first_page":"578","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8840000033378601},{"id":"https://openalex.org/keywords/myogenic-tone","display_name":"myogenic tone","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mesenteric-resistance-arteries","display_name":"mesenteric resistance arteries","score":0.9459999799728394},{"id":"https://openalex.org/keywords/prkcb","display_name":"protein kinase C beta","score":0.7730000019073486},{"id":"https://openalex.org/keywords/prostanoids","display_name":"prostanoids","score":0.8119999766349792},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7730000019073486},{"id":"https://openalex.org/keywords/endothelium-dependent-vasodilation","display_name":"endothelium-dependent vasodilation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.6970000267028809},{"id":"https://openalex.org/keywords/sq29548","display_name":"SQ29548","score":0.8080000281333923},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.6959999799728394},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.675000011920929},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.7350000143051147},{"id":"https://openalex.org/keywords/vasoconstriction","display_name":"vasoconstriction","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8574488759040833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8541200160980225},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6764274835586548},{"id":"https://openalex.org/C2780771799","wikidata":"https://www.wikidata.org/wiki/Q109592502","display_name":"Mesenteric arteries","level":3,"score":0.6536623239517212},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5907347202301025},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.4954115152359009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4376239776611328},{"id":"https://openalex.org/C2778266237","wikidata":"https://www.wikidata.org/wiki/Q962217","display_name":"Prostanoid","level":3,"score":0.4137806296348572},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29375553131103516},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.23481833934783936},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23347550630569458},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1525917649269104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09788087010383606}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010656","descriptor_name":"Phenylephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014665","descriptor_name":"Vasodilator Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014666","descriptor_name":"Vasomotor System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052250","descriptor_name":"Nitric Oxide Synthase Type III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000051094","doi":"https://doi.org/10.1159/000051094","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000051094","pdf_url":null,"source":{"id":"https://openalex.org/S150425866","display_name":"Journal of Vascular Research","issn_l":"1018-1172","issn":["1018-1172","1423-0135"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Research","raw_type":"journal-article"},{"id":"pmid:11740157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11740157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of vascular research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W90548255","https://openalex.org/W134980868","https://openalex.org/W1600112913","https://openalex.org/W1619653867","https://openalex.org/W1873880225","https://openalex.org/W1912513757","https://openalex.org/W1968402657","https://openalex.org/W1969623264","https://openalex.org/W1969683304","https://openalex.org/W1976045324","https://openalex.org/W1980194826","https://openalex.org/W1990394848","https://openalex.org/W1993783817","https://openalex.org/W1996216127","https://openalex.org/W1999067730","https://openalex.org/W2002365952","https://openalex.org/W2020053653","https://openalex.org/W2030904049","https://openalex.org/W2035498702","https://openalex.org/W2052523241","https://openalex.org/W2059052527","https://openalex.org/W2064689833","https://openalex.org/W2080831128","https://openalex.org/W2085141749","https://openalex.org/W2093475267","https://openalex.org/W2127821660","https://openalex.org/W2128619290","https://openalex.org/W2144100801","https://openalex.org/W2151219965","https://openalex.org/W2152156058","https://openalex.org/W2184759784","https://openalex.org/W2272087247","https://openalex.org/W2394628090","https://openalex.org/W2409671717","https://openalex.org/W2413340482","https://openalex.org/W3157860773"],"related_works":["https://openalex.org/W2144705976","https://openalex.org/W1999064407","https://openalex.org/W2063934872","https://openalex.org/W2010263704","https://openalex.org/W2136433300","https://openalex.org/W2131890454","https://openalex.org/W4241146869","https://openalex.org/W126711757","https://openalex.org/W7111843049","https://openalex.org/W2127488172"],"abstract_inverted_index":{"An":[0],"arteriograph":[1],"was":[2,103],"used":[3],"to":[4,130,171],"assess":[5],"myogenic":[6,37,76,91,160],"tone,":[7],"smooth":[8],"muscle":[9],"contractility":[10],"and":[11,26,28,44,49,79,101,108,112,143,150,188,194,222],"the":[12,148,158],"influence":[13],"of":[14,52,71,138,174,220,224],"endothelial":[15,233],"function":[16],"on":[17],"mesenteric":[18],"resistance":[19,163],"artery":[20],"reactivity":[21],"in":[22,33,39,57,60,67,87,93,105,127,132,147,162,184,197,232],"insulin-resistant":[23],"mice":[24,107,167,199],"(C57BL/KsJ-db/db)":[25],"age-":[27],"gender-matched":[29],"wild-type":[30],"mice.":[31,46,62,95,134,152],"Increases":[32],"transmural":[34],"pressure":[35],"induced":[36,98],"tone":[38,55,92,161],"arteries":[40,72,164],"from":[41,165],"both":[42],"control":[43,61,133,151],"db/db":[45,68,94,106,128,149],"At":[47],"12":[48],"16":[50],"weeks":[51],"age,":[53],"greater":[54,159,172],"developed":[56],"diabetic":[58,166,185],"than":[59],"In":[63],"control,":[64,88],"but":[65,89],"not":[66],"mice,":[69,186],"pretreatment":[70],"with":[73,236],"L-NAME":[74],"potentiated":[75,109],"tone.":[77],"Indomethacin":[78],"SQ29548":[80,111],"(PGH2/TXA2":[81],"receptor":[82],"antagonist)":[83],"had":[84],"no":[85],"efffect":[86],"inhibited":[90],"Endothelium-dependent":[96],"vasodilation":[97],"by":[99,110,203,213],"acetylcholine":[100],"bradykinin,":[102],"depressed":[104,193],"LY333531":[113],"(protein":[114],"kinase":[115],"C(beta)":[116],"inhibitor).":[117],"Messenger":[118],"RNA":[119],"expression":[120,136],"levels":[121,137],"for":[122,140],"PKC(beta)":[123,221],"were":[124,145],"over-expressed":[125],"2.5-fold":[126],"relative":[129],"those":[131],"However,":[135],"mRNA":[139],"eNOS,":[141],"PKC(alpha),":[142],"PKC(xi)":[144],"similar":[146],"Collectively,":[153],"these":[154,198],"results":[155],"suggest":[156],"that":[157,183],"may":[168,200],"be":[169,201],"attributable,":[170],"amounts":[173],"one":[175],"or":[176],"more":[177],"vasoconstricting":[178],"prostanoids.":[179],"Our":[180],"data":[181],"indicate":[182],"basal":[187],"agonist-stimulated":[189],"NO":[190],"releases":[191],"are":[192],"NO-mediated":[195],"vasorelaxation":[196],"countered":[202],"an":[204],"endogenous":[205],"vasoconstrictive":[206],"prostanoid.":[207],"This":[208],"prostanoid-induced":[209],"vasoconstriction":[210],"is":[211],"mediated":[212],"a":[214,225,230],"PKC(beta)-dependent":[215],"mechanism.":[216],"Therefore,":[217],"heightened":[218],"activation":[219],"release":[223],"vasoconstrictor":[226],"prostanoid":[227],"could":[228],"play":[229],"role":[231],"dysfunction":[234],"associated":[235],"type":[237],"II":[238],"diabetes.":[239]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}