{"id":"https://openalex.org/W2007396170","doi":"https://doi.org/10.1002/art.30309","title":"Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production","display_name":"Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production","publication_year":2011,"publication_date":"2011-02-26","ids":{"openalex":"https://openalex.org/W2007396170","doi":"https://doi.org/10.1002/art.30309","mag":"2007396170","pmid":"https://pubmed.ncbi.nlm.nih.gov/21360521"},"language":"en","primary_location":{"id":"doi:10.1002/art.30309","doi":"https://doi.org/10.1002/art.30309","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.30309","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035139710","display_name":"Koichi Oshita","orcid":"https://orcid.org/0000-0001-7109-1534","observed_orcids":["https://orcid.org/0000-0001-7109-1534"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Oshita","raw_affiliation_strings":["First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034591782","display_name":"Kunihiro Yamaoka","orcid":"https://orcid.org/0000-0001-8858-9435","observed_orcids":["https://orcid.org/0000-0001-8858-9435"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiro Yamaoka","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034320377","display_name":"Nobuyuki Udagawa","orcid":"https://orcid.org/0000-0002-4075-8698","observed_orcids":["https://orcid.org/0000-0002-4075-8698"]},"institutions":[{"id":"https://openalex.org/I90960554","display_name":"Matsumoto Dental University","ror":"https://ror.org/041jyt122","country_code":"JP","type":"education","lineage":["https://openalex.org/I90960554"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyuki Udagawa","raw_affiliation_strings":["Matsumoto Dental Univ., Shiojiri, Nagano (Japan)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Matsumoto Dental Univ., Shiojiri, Nagano (Japan)","institution_ids":["https://openalex.org/I90960554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061703808","display_name":"Shunsuke Fukuyo","orcid":"https://orcid.org/0000-0001-7006-8826","observed_orcids":["https://orcid.org/0000-0001-7006-8826"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Fukuyo","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082070205","display_name":"Koshiro Sonomoto","orcid":"https://orcid.org/0000-0002-4003-8842","observed_orcids":["https://orcid.org/0000-0002-4003-8842"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koshiro Sonomoto","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011313885","display_name":"Keisuke Maeshima","orcid":"https://orcid.org/0000-0002-9251-5997","observed_orcids":["https://orcid.org/0000-0002-9251-5997"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keisuke Maeshima","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015488234","display_name":"Ryuji Kurihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryuji Kurihara","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061676124","display_name":"Kazuhisa Nakano","orcid":"https://orcid.org/0000-0002-1272-2997","observed_orcids":["https://orcid.org/0000-0002-1272-2997"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhisa Nakano","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041976581","display_name":"Kazuyoshi Saito","orcid":"https://orcid.org/0000-0002-3300-3764","observed_orcids":["https://orcid.org/0000-0002-3300-3764"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuyoshi Saito","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028248498","display_name":"Yosuke Okada","orcid":"https://orcid.org/0000-0003-4998-9078","observed_orcids":["https://orcid.org/0000-0003-4998-9078"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yosuke Okada","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012275284","display_name":"Kenji Chiba","orcid":"https://orcid.org/0000-0002-1687-1746","observed_orcids":["https://orcid.org/0000-0002-1687-1746"]},"institutions":[{"id":"https://openalex.org/I4387155982","display_name":"Tanabe Pharma Corporation (Japan)","ror":"https://ror.org/038ehsm73","country_code":"JP","type":"company","lineage":["https://openalex.org/I168192097","https://openalex.org/I4387155982"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Chiba","raw_affiliation_strings":["Mitsubishi Tanabe Pharma Corporation Yokohama Kanagawa Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mitsubishi Tanabe Pharma Corporation Yokohama Kanagawa Japan","institution_ids":["https://openalex.org/I4387155982"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015953107","display_name":"Yoshiya Tanaka","orcid":"https://orcid.org/0000-0002-0807-7139","observed_orcids":["https://orcid.org/0000-0002-0807-7139"]},"institutions":[{"id":"https://openalex.org/I188700360","display_name":"University of Occupational and Environmental Health Japan","ror":"https://ror.org/020p3h829","country_code":"JP","type":"education","lineage":["https://openalex.org/I188700360"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiya Tanaka","raw_affiliation_strings":["University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Occupational and Environmental Health, Japan Kitakyushu, Fukuoka Japan","institution_ids":["https://openalex.org/I188700360"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3539,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.89281114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"63","issue":"6","first_page":"1658","last_page":"1667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8481000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.1265999972820282,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cathepsin-k","display_name":"cathepsin K","score":0.8859999775886536},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.9700000286102295},{"id":"https://openalex.org/keywords/joint-damage","display_name":"joint destruction","score":0.5550000071525574},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.8742064237594604},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.8082349300384521},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.7922241687774658},{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.7400241494178772},{"id":"https://openalex.org/C101990758","wikidata":"https://www.wikidata.org/wiki/Q14902045","display_name":"Cathepsin K","level":4,"score":0.649021565914154},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.530432939529419},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5281778573989868},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5277279615402222},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45073381066322327},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.44860389828681946},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34209874272346497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24725931882858276},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14761745929718018},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14393413066864014},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12524068355560303},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09762006998062134},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.07585409283638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071681","descriptor_name":"Tartrate-Resistant Acid Phosphatase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012213","descriptor_name":"Rheumatic Fever","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053244","descriptor_name":"Osteoprotegerin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D056657","descriptor_name":"Cathepsin K","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/art.30309","doi":"https://doi.org/10.1002/art.30309","is_oa":false,"landing_page_url":"https://doi.org/10.1002/art.30309","pdf_url":null,"source":{"id":"https://openalex.org/S132787887","display_name":"Arthritis & Rheumatism","issn_l":"0004-3591","issn":["0004-3591","1529-0131"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis &amp; Rheumatism","raw_type":"journal-article"},{"id":"pmid:21360521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21360521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis and rheumatism","raw_type":"Journal Article"},{"id":"mag:2334400469","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/500000569917","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1677043489","https://openalex.org/W1976732545","https://openalex.org/W1981787940","https://openalex.org/W1992613188","https://openalex.org/W1996028579","https://openalex.org/W2003284223","https://openalex.org/W2006443329","https://openalex.org/W2021821328","https://openalex.org/W2030653181","https://openalex.org/W2032384549","https://openalex.org/W2034004034","https://openalex.org/W2034976876","https://openalex.org/W2039665103","https://openalex.org/W2044561904","https://openalex.org/W2046390154","https://openalex.org/W2051297632","https://openalex.org/W2051752053","https://openalex.org/W2056269123","https://openalex.org/W2058858133","https://openalex.org/W2059858822","https://openalex.org/W2070150094","https://openalex.org/W2072153114","https://openalex.org/W2089592611","https://openalex.org/W2095666785","https://openalex.org/W2096884368","https://openalex.org/W2103893610","https://openalex.org/W2106117542","https://openalex.org/W2109352335","https://openalex.org/W2116500923","https://openalex.org/W2124857894","https://openalex.org/W2129651548","https://openalex.org/W2133694413","https://openalex.org/W2138946470","https://openalex.org/W2150952126","https://openalex.org/W2156467557","https://openalex.org/W2156959186","https://openalex.org/W2157299977","https://openalex.org/W2159999899","https://openalex.org/W2168295783"],"related_works":["https://openalex.org/W2332230701","https://openalex.org/W2145992217","https://openalex.org/W1978274015","https://openalex.org/W2201173177","https://openalex.org/W3010219133","https://openalex.org/W2034072988","https://openalex.org/W2944760967","https://openalex.org/W4313385985","https://openalex.org/W4313366195","https://openalex.org/W7097799843"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Mesenchymal":[1],"stem":[2],"cells":[3,83,97,116,130,195],"(MSCs)":[4],"have":[5],"been":[6],"proposed":[7],"to":[8,55,68],"be":[9,251],"a":[10,142,181,244],"useful":[11],"tool":[12],"for":[13],"treatment":[14,166],"of":[15,22,28,59,107,114,121,127,138,188,193,201,222,226,234,255],"rheumatoid":[16],"arthritis":[17],"(RA),":[18],"not":[19,162],"only":[20,180],"because":[21,27],"their":[23,29,70],"multipotency":[24],"but":[25],"also":[26],"immunosuppressive":[30],"effect":[31,58,187,246],"on":[32,61,247],"lymphocytes,":[33],"dendritic":[34],"cells,":[35],"and":[36,64,79,105,119,124,155,224,228],"other":[37],"proinflammatory":[38],"cells.":[39],"Since":[40],"bone":[41],"destruction":[42],"caused":[43],"by":[44,100,135,153,199],"activated":[45,128],"osteoclasts":[46],"occurs":[47],"in":[48,66,73,184,220,231,253,258],"RA,":[49],"we":[50,238],"undertook":[51],"the":[52,57,136,185,205,232],"present":[53,210],"study":[54],"investigate":[56],"MSCs":[60,78,140,154,215,242],"osteoclast":[62,91,108,159],"function":[63],"differentiation":[65,109,160],"order":[67],"evaluate":[69],"potential":[71],"use":[72],"RA":[74],"therapy.":[75],"METHODS:":[76],"Human":[77],"peripheral":[80],"blood":[81],"mononuclear":[82],"were":[84],"cultured":[85],"under":[86],"cell-cell":[87,235],"contact-free":[88],"conditions":[89],"with":[90,167],"induction":[92],"medium.":[93,207],"Differentiation":[94],"into":[95,204],"osteoclast-like":[96,115,194],"was":[98,117,133,150,161,196],"determined":[99],"tartrate-resistant":[101],"acid":[102],"phosphatase":[103],"staining":[104],"expression":[106,120,225],"markers.":[110],"RESULTS:":[111],"The":[112,209],"number":[113],"decreased":[118],"cathepsin":[122,229],"K":[123,230],"nuclear":[125],"factor":[126],"T":[129],"c1":[131],"(NF-ATc1)":[132],"down-regulated":[134],"addition":[137,200],"either":[139,168],"or":[141,171],"conditioned":[143,206],"medium":[144],"obtained":[145],"from":[146],"MSCs.":[147,189],"Osteoprotegerin":[148],"(OPG)":[149],"constitutively":[151,216],"produced":[152],"inhibited":[156],"osteoclastogenesis.":[157],"However,":[158],"fully":[163],"recovered":[164,198],"upon":[165],"anti-OPG":[169,202],"antibody":[170,203],"OPG":[172,178],"small":[173],"interfering":[174],"RNA,":[175],"suggesting":[176],"that":[177,213,240],"had":[179],"partial":[182],"role":[183],"inhibitory":[186],"Moreover,":[190],"bone-resorbing":[191],"activity":[192],"partially":[197],"CONCLUSION:":[208],"results":[211],"indicate":[212],"human":[214,241],"produce":[217],"OPG,":[218],"resulting":[219],"inhibition":[221,254],"osteoclastogenesis":[223],"NF-ATc1":[227],"absence":[233],"contact.":[236],"Therefore,":[237],"conclude":[239],"exert":[243],"suppressive":[245],"osteoclastogenesis,":[248],"which":[249],"may":[250],"beneficial":[252],"joint":[256],"damage":[257],"RA.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
