{"id":"https://openalex.org/W2007394757","doi":"https://doi.org/10.1002/jcp.1041210218","title":"Effects of 2\u2032,3\u2032\u2010dideoxynucleosides on mammalian cells and viruses","display_name":"Effects of 2\u2032,3\u2032\u2010dideoxynucleosides on mammalian cells and viruses","publication_year":1984,"publication_date":"1984-11-01","ids":{"openalex":"https://openalex.org/W2007394757","doi":"https://doi.org/10.1002/jcp.1041210218","mag":"2007394757","pmid":"https://pubmed.ncbi.nlm.nih.gov/6092393"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041210218","doi":"https://doi.org/10.1002/jcp.1041210218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041210218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103233537","display_name":"M. Anwar Waqar","orcid":"https://orcid.org/0000-0001-8937-0590","observed_orcids":["https://orcid.org/0000-0001-8937-0590"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Anwar Waqar","raw_affiliation_strings":["Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109995999","display_name":"Mary Jo Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Jo Evans","raw_affiliation_strings":["Biological Resources, Roswell Park Memorial Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Resources, Roswell Park Memorial Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006448639","display_name":"Kenneth F. Manly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth F. Manly","raw_affiliation_strings":["Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111523115","display_name":"Robert G. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert G. Hughes","raw_affiliation_strings":["Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109240661","display_name":"Joel A. Huberman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel A. Huberman","raw_affiliation_strings":["Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell and Tumor Biology, Roswell Park Memorial Institute, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109240661"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":8.5344,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.98073187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"121","issue":"2","first_page":"402","last_page":"408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.07240000367164612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-3-dideoxynucleosides","display_name":"2',3'-dideoxynucleosides","score":0.9959999918937683},{"id":"https://openalex.org/keywords/5-triphosphate","display_name":"5'-triphosphate","score":0.7310000061988831},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibition","display_name":"reverse transcriptase inhibition","score":0.8389999866485596},{"id":"https://openalex.org/keywords/retrovirus-infection","display_name":"retroviral infection","score":0.8209999799728394},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.7630000114440918},{"id":"https://openalex.org/keywords/murine-leukemia-virus","display_name":"murine leukemia virus","score":0.9150000214576721},{"id":"https://openalex.org/keywords/nucleoside-phosphorylation","display_name":"nucleoside phosphorylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/cv-1-cells","display_name":"CV-1 cells","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6780849099159241},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6686763763427734},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.6327474117279053},{"id":"https://openalex.org/C2756471","wikidata":"https://www.wikidata.org/wiki/Q206286","display_name":"DNA polymerase","level":3,"score":0.5627020001411438},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5506507754325867},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.5389720797538757},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.46946823596954346},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.4684441387653351},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45972320437431335},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4579656422138214},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4493086338043213},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43211278319358826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38932862877845764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34561392664909363},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12822505831718445},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.09436473250389099}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003853","descriptor_name":"Deoxyribonucleosides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003853","descriptor_name":"Deoxyribonucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003854","descriptor_name":"Deoxyribonucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009052","descriptor_name":"Leukemia Virus, Murine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019384","descriptor_name":"Nucleic Acid Synthesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041210218","doi":"https://doi.org/10.1002/jcp.1041210218","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041210218","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:6092393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6092393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6044999957084656}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1485519622","https://openalex.org/W1556066808","https://openalex.org/W1655438960","https://openalex.org/W1666450573","https://openalex.org/W1757069992","https://openalex.org/W1865355173","https://openalex.org/W1999531687","https://openalex.org/W2011759132","https://openalex.org/W2011813865","https://openalex.org/W2014015430","https://openalex.org/W2030511707","https://openalex.org/W2034129313","https://openalex.org/W2041816262","https://openalex.org/W2048518905","https://openalex.org/W2052679757","https://openalex.org/W2052858665","https://openalex.org/W2056934184","https://openalex.org/W2061199723","https://openalex.org/W2064035749","https://openalex.org/W2081794272","https://openalex.org/W2093637750","https://openalex.org/W2112769550"],"related_works":["https://openalex.org/W2411249716","https://openalex.org/W2061199723","https://openalex.org/W2027217776","https://openalex.org/W2021385110","https://openalex.org/W1843999247","https://openalex.org/W1909341276","https://openalex.org/W2041816262","https://openalex.org/W2407899030","https://openalex.org/W2000540132","https://openalex.org/W2011082013"],"abstract_inverted_index":{"Previous":[0,44],"studies":[1,45],"on":[2,24,126,216],"the":[3,7,25,50,84,87,104,127,148,172],"biological":[4,206],"effects":[5,23,125,136,212],"of":[6,27,37,52,86,129,144,213,229,241],"2',3'-dideoxynucleosides":[8],"(ddNs)":[9],"have":[10,46,77,123,151,205],"shown":[11,48],"that":[12,32,49,83,113],"while":[13],"ddAdo":[14,180,188,236],"is":[15,71,160,251,268],"lethal":[16],"to":[17,74,81,120,140,147,168,199],"E.":[18],"coli,":[19],"ddThd":[20,159,223,258],"has":[21,237],"minimal":[22],"growth":[26,128],"mammalian":[28],"cell":[29,39,157,174],"lines":[30,40],"and":[31,61,63,93,101,170,181,189,191,257],"it":[33],"inhibits":[34,56,224],"retrovirus":[35],"infection":[36,228],"some":[38],"but":[41,262],"not":[42],"others.":[43],"also":[47,111,184],"5'-triphosphate":[51],"ddThd,":[53,193],"ddTTP,":[54,169],"selectively":[55],"cellular":[57,96],"DNA":[58,68,97],"polymerases":[59,98],"beta":[60],"gamma":[62,102],"retroviral":[64],"reverse":[65],"transcriptases.":[66],"Cellular":[67],"polymerase":[69],"alpha":[70],"relatively":[72],"resistant":[73],"ddTTP.":[75,109],"We":[76,110,150],"extended":[78],"these":[79],"findings":[80],"show":[82,112],"5'-triphosphates":[85],"other":[88],"3":[89],"ddNs":[90,116,210],"(ddATP,":[91],"ddCTP,":[92],"ddGTP)":[94],"affect":[95],"alpha,":[99],"beta,":[100],"in":[103,117,154,171],"same":[105],"fashion":[106],"as":[107],"does":[108],"all":[114],"four":[115,209],"concentrations":[118],"up":[119],"100":[121],"microM":[122,222,235,266],"negligible":[124,135],"NIH":[130,242],"Swiss":[131,243],"3T3":[132,244],"cells.":[133],"These":[134],"may":[137,204],"be":[138],"due":[139],"inefficient":[141],"intracellular":[142],"phosphorylation":[143],"each":[145],"nucleoside":[146],"triphosphate.":[149],"determined":[152],"that,":[153],"several":[155],"different":[156,214],"lines,":[158],"phosphorylated":[161],"only":[162],"at":[163,259],"a":[164],"very":[165],"slow":[166],"rate":[167],"one":[173],"line":[175],"tested":[176],"(monkey":[177],"CV-1":[178,197,230],"cells),":[179],"ddGuo":[182,267],"are":[183,194],"poorly":[185],"phosphorylated.":[186],"Both":[187],"ddGuo,":[190],"probably":[192],"converted":[195],"by":[196,232,246,254,264],"cells":[198,231,245],"additional":[200],"unknown":[201],"compounds":[202],"which":[203],"activity.":[207],"The":[208],"display":[211],"magnitudes":[215],"certain":[217],"virus":[218,250],"infections.":[219],"Although":[220],"30":[221,234],"herpes":[225],"simplex":[226],"I":[227],"50%,":[233],"no":[238],"effect.":[239],"Infection":[240],"334C":[247],"murine":[248],"leukemia":[249],"inhibited":[252],"70-80%":[253],"ddAdo,":[255],"ddCyd,":[256],"50":[260,265],"microM,":[261],"inhibition":[263],"100%.":[269]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}