{"id":"https://openalex.org/W2007389630","doi":"https://doi.org/10.1117/12.560750","title":"Simulation of heart infarction by laser microbeams and induction of arrhythmias by optical tweezers","display_name":"Simulation of heart infarction by laser microbeams and induction of arrhythmias by optical tweezers","publication_year":2004,"publication_date":"2004-10-18","ids":{"openalex":"https://openalex.org/W2007389630","doi":"https://doi.org/10.1117/12.560750","mag":"2007389630"},"language":"en","primary_location":{"id":"doi:10.1117/12.560750","doi":"https://doi.org/10.1117/12.560750","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.560750","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000950875","display_name":"Birgit Perner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Birgit Perner","raw_affiliation_strings":["Institute for Biomolecular Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomolecular Technology (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033905889","display_name":"Shamci Monajembashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shamci Monajembashi","raw_affiliation_strings":["Institute for Biomolecular Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomolecular Technology (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003366735","display_name":"Alexander W. Rapp","orcid":"https://orcid.org/0000-0001-9108-3929","observed_orcids":["https://orcid.org/0000-0001-9108-3929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Rapp","raw_affiliation_strings":["Institute for Biomolecular Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomolecular Technology (Germany)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038289671","display_name":"Leo Wollweber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leo Wollweber","raw_affiliation_strings":["Institute for Biomolecular Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomolecular Technology (Germany)","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045761618","display_name":"Karl Otto Greulich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl Otto Greulich","raw_affiliation_strings":["Institute for Biomolecular Technology (Germany)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomolecular Technology (Germany)","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5591,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.93380615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5514","issue":null,"first_page":"179","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.6699000000953674,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10490","display_name":"Orbital Angular Momentum in Optics","score":0.06109999865293503,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.03790000081062317,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/laser-microbeam","display_name":"laser microbeam","score":0.8429999947547913},{"id":"https://openalex.org/keywords/optical-tweezers","display_name":"optical tweezers","score":0.9909999966621399},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8149999976158142},{"id":"https://openalex.org/keywords/calcium-waves","display_name":"calcium waves","score":0.7820000052452087},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cardiac-arrhythmia","display_name":"cardiac arrhythmias","score":0.6050000190734863},{"id":"https://openalex.org/keywords/myocardial-injury","display_name":"myocardial injury","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.5690000057220459},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C20198109","wikidata":"https://www.wikidata.org/wiki/Q1066633","display_name":"Optical tweezers","level":2,"score":0.8650158643722534},{"id":"https://openalex.org/C2777152588","wikidata":"https://www.wikidata.org/wiki/Q6839237","display_name":"Microbeam","level":2,"score":0.7062228918075562},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.4869581162929535},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4307999014854431},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.42478200793266296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.328158438205719},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2119397521018982},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.21044448018074036},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18873584270477295},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.17533263564109802}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.560750","doi":"https://doi.org/10.1117/12.560750","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.560750","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1545635052","https://openalex.org/W4294300881","https://openalex.org/W2784709294","https://openalex.org/W4386774276","https://openalex.org/W2912859666","https://openalex.org/W2084601150","https://openalex.org/W3034811978","https://openalex.org/W2086218498","https://openalex.org/W3068200667","https://openalex.org/W2997619117"],"abstract_inverted_index":{"Laser":[0],"microbeam":[1,24],"and":[2,19,90,164,202],"optical":[3,81],"tweezers":[4,82],"were":[5,44],"used":[6,192],"for":[7,85],"micromanipulation":[8],"of":[9,15,32,41,53,73,88,96,99,105,142,161,178,197,204],"a":[10,25,30,103,185],"heart":[11,34,144],"tissue":[12],"model":[13],"consisting":[14],"embryonic":[16],"chicken":[17],"cardiomyocytes":[18,63,89,108],"bibroblasts.":[20],"Using":[21],"the":[22,140,176,187,195,207],"laser":[23],"would":[26,55],"was":[27,36,64,83,120],"created,":[28],"i.e.":[29],"sort":[31],"artificial":[33,143],"infarction":[35,145],"generated.":[37],"The":[38,134],"first":[39],"steps":[40],"wound":[42,200],"repair":[43],"observed":[45],"by":[46,57,62,80,109,172],"live":[47],"cell":[48],"imaging.":[49],"A":[50],"complete":[51],"filling":[52],"teh":[54],"primarily":[56],"migrating":[58],"fibroblasts":[59,125],"but":[60],"not":[61],"detected":[65],"18":[66],"hours":[67],"after":[68,152],"wounding.":[69],"In":[70],"another":[71],"set":[72],"experiments":[74],"erythrocyte":[75],"mediated":[76],"force":[77],"application":[78],"(EMFA)":[79],"applied":[84],"optomechanical":[86,111],"manipulatoin":[87],"fibroblasts.":[91],"Here":[92],"we":[93],"demonstrate":[94],"induction":[95,141],"dramatic":[97],"distrubances":[98],"calcium":[100,132],"waves":[101],"in":[102,115,206],"group":[104],"synchronously":[106],"beating":[107,205],"an":[110],"input":[112],"that":[113,122,139],"results":[114,135],"cellular":[116],"deformation.":[117],"Surprisingly,":[118],"it":[119],"found":[121],"putatively":[123],"non-excitable":[124],"respond":[126],"to":[127,158,165,193],"this":[128],"mechanical":[129,173],"stress":[130,174],"with":[131],"oscillations.":[133],"reported":[136],"here":[137],"indicate":[138],"can":[146],"provide":[147,166],"insights":[148],"into":[149],"healing":[150,201],"processes":[151,170],"mycardial":[153],"injury.":[154],"EMFA":[155],"is":[156],"capable":[157],"examine":[159],"effects":[160],"myocardial":[162],"overload":[163],"important":[167],"information":[168],"about":[169],"triggered":[171],"on":[175,199],"level":[177],"single":[179],"or":[180],"very":[181],"few":[182],"cells.":[183],"As":[184],"perspective,":[186],"preseneted":[188],"techniques":[189],"may":[190],"be":[191],"study":[194],"influence":[196],"drugs":[198],"coordination":[203],"heart.":[208]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}