{"id":"https://openalex.org/W2007385282","doi":"https://doi.org/10.1134/s0026261709050075","title":"Lysine decarboxylase activity as a factor of fluoroquinolone resistance in Escherichia coli","display_name":"Lysine decarboxylase activity as a factor of fluoroquinolone resistance in Escherichia coli","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2007385282","doi":"https://doi.org/10.1134/s0026261709050075","mag":"2007385282"},"language":"en","primary_location":{"id":"doi:10.1134/s0026261709050075","doi":"https://doi.org/10.1134/s0026261709050075","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026261709050075","pdf_url":null,"source":{"id":"https://openalex.org/S4210199608","display_name":"Microbiology","issn_l":"0026-2617","issn":["0026-2617","1608-3237","3034-5464"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2007385282"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080672541","display_name":"\u0410. \u0412. \u0410\u0445\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-3477-750X","observed_orcids":["https://orcid.org/0000-0002-3477-750X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210144800","display_name":"Institute of Ecology and Genetics of Microorganisms","ror":"https://ror.org/04e09qg36","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210144800"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Akhova","raw_affiliation_strings":["Institute of Ecology and Genetics of Microorganisms, Urals Division, Russian Academy of Sciences, Perm\u2019, Russia","Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Genetics of Microorganisms, Urals Division, Russian Academy of Sciences, Perm\u2019, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"]},{"raw_affiliation_string":"Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075961947","display_name":"\u0410. \u0413. \u0422\u043a\u0430\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-8631-8583","observed_orcids":["https://orcid.org/0000-0002-8631-8583"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210144800","display_name":"Institute of Ecology and Genetics of Microorganisms","ror":"https://ror.org/04e09qg36","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210144800"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. G. Tkachenko","raw_affiliation_strings":["Institute of Ecology and Genetics of Microorganisms, Urals Division, Russian Academy of Sciences, Perm\u2019, Russia","Russian Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Genetics of Microorganisms, Urals Division, Russian Academy of Sciences, Perm\u2019, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"]},{"raw_affiliation_string":"Russian Academy of Sciences","institution_ids":["https://openalex.org/I1313323035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5075961947"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"],"apc_list":null,"apc_paid":null,"fwci":0.1462,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.46340113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"78","issue":"5","first_page":"575","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysine-decarboxylase","display_name":"lysine decarboxylase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fluoroquinolone-resistance","display_name":"fluoroquinolone resistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rpos","display_name":"RpoS","score":0.699999988079071},{"id":"https://openalex.org/keywords/sigma-factor","display_name":"sigma factor","score":0.6359999775886536},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sublethal-antibiotic-exposure","display_name":"sublethal antibiotic exposure","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antibiotic-penetration","display_name":"antibiotic penetration","score":0.5619999766349792},{"id":"https://openalex.org/keywords/bacterial-stress-response","display_name":"bacterial stress response","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2779703059","wikidata":"https://www.wikidata.org/wiki/Q3269766","display_name":"Lysine decarboxylase","level":5,"score":0.924956202507019},{"id":"https://openalex.org/C2777712861","wikidata":"https://www.wikidata.org/wiki/Q7375543","display_name":"rpoS","level":5,"score":0.8833479881286621},{"id":"https://openalex.org/C2776928777","wikidata":"https://www.wikidata.org/wiki/Q161555","display_name":"Cadaverine","level":4,"score":0.7548692226409912},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6869730949401855},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6183398365974426},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4440034329891205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43484610319137573},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.433262437582016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4166640639305115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3687000274658203},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36708304286003113},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11875727772712708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06553491950035095},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06416836380958557},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.05871903896331787},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1134/s0026261709050075","doi":"https://doi.org/10.1134/s0026261709050075","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026261709050075","pdf_url":null,"source":{"id":"https://openalex.org/S4210199608","display_name":"Microbiology","issn_l":"0026-2617","issn":["0026-2617","1608-3237","3034-5464"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},{"id":"mag:2801613312","doi":null,"is_oa":false,"landing_page_url":"http://naukarus.com/lizindekarboksilaznaya-aktivnost-kak-faktor-rezistentnosti-escherichia-coli-k-ftorhinolonam","pdf_url":null,"source":{"id":"https://openalex.org/S4210168028","display_name":"\u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f","issn_l":"0026-3656","issn":["0026-3656"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-1"],"host_organization":"https://openalex.org/P4310319820","host_organization_name":"MAIK Nauka/Interperiodica","host_organization_lineage":["https://openalex.org/P4310319820","https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["MAIK Nauka/Interperiodica","Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u043b\u043e\u0433\u0438\u044f","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1533609388","https://openalex.org/W1546783991","https://openalex.org/W1590605000","https://openalex.org/W1775749144","https://openalex.org/W1979767547","https://openalex.org/W1982138676","https://openalex.org/W1983009138","https://openalex.org/W1983423377","https://openalex.org/W2008567092","https://openalex.org/W2016264855","https://openalex.org/W2065583896","https://openalex.org/W2076093949","https://openalex.org/W2080824984","https://openalex.org/W2103044506","https://openalex.org/W2116879945","https://openalex.org/W2129870891","https://openalex.org/W2134978522","https://openalex.org/W2135280879","https://openalex.org/W2159579053","https://openalex.org/W2408231667","https://openalex.org/W2425809087"],"related_works":["https://openalex.org/W3199162226","https://openalex.org/W1985778379","https://openalex.org/W2802766191","https://openalex.org/W2736010438","https://openalex.org/W2561795844","https://openalex.org/W4406635423","https://openalex.org/W7117245817","https://openalex.org/W2040445226","https://openalex.org/W1999927181"],"abstract_inverted_index":{"Exposure":[0],"of":[1,8,12,50,53,82,86,106,119,132,134,142],"E.":[2,91],"coli":[3,92],"cells":[4],"to":[5,20,97],"sublethal":[6],"concentrations":[7],"fluoroquinolones":[9],"induced":[10],"synthesis":[11],"lysine":[13,87],"decarboxylase":[14,88],"LdcC,":[15],"which":[16],"was":[17,77],"previously":[18],"considered":[19],"be":[21],"a":[22,28,60],"constitutive":[23],"enzyme.":[24],"Under":[25],"these":[26],"conditions,":[27],"key":[29],"role":[30],"in":[31,47,90,101,125],"this":[32],"process":[33],"is":[34,124],"played":[35],"by":[36],"RNA":[37],"polymerase":[38],"\u03c3":[39],"S":[40],"subunit":[41],"(RpoS);":[42],"its":[43],"quantity":[44],"increased":[45],"substantially":[46],"the":[48,54,71,80,84,107,120,129],"presence":[49],"antibiotics.":[51,73,122],"Fluoroquinolones":[52],"second":[55,108],"and":[56,67,94,109],"third":[57],"generations":[58,136],"had":[59,113],"more":[61],"pronounced":[62],"effect":[63,115],"on":[64,116],"rpoS":[65],"expression":[66],"LdcC":[68],"activity":[69,118],"than":[70],"first-generation":[72,121],"A":[74],"direct":[75],"correlation":[76],"shown":[78],"between":[79],"level":[81],"cadaverine,":[83],"product":[85],"reaction":[89],"cells,":[93],"their":[95,143],"resistance":[96],"fluoroquinolones.":[98],"An":[99],"increase":[100],"endogenous":[102],"cadaverine":[103],"reduced":[104],"effectiveness":[105],"third-generation":[110],"fluoroquinolones,":[111],"but":[112],"no":[114],"antimicrobial":[117],"This":[123],"good":[126],"agreement":[127],"with":[128,139],"hydrophilic":[130],"properties":[131],"antibiotics":[133],"different":[135,140],"and,":[137],"consequently,":[138],"mechanisms":[141],"penetration":[144],"into":[145],"bacterial":[146],"cells.":[147]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
