{"id":"https://openalex.org/W2007383919","doi":"https://doi.org/10.1002/jcp.21987","title":"Ex vivo expansion of human mesenchymal stem cells: A more effective cell proliferation kinetics and metabolism under hypoxia","display_name":"Ex vivo expansion of human mesenchymal stem cells: A more effective cell proliferation kinetics and metabolism under hypoxia","publication_year":2009,"publication_date":"2009-12-17","ids":{"openalex":"https://openalex.org/W2007383919","doi":"https://doi.org/10.1002/jcp.21987","mag":"2007383919","pmid":"https://pubmed.ncbi.nlm.nih.gov/20020504"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.21987","doi":"https://doi.org/10.1002/jcp.21987","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.21987","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101829624","display_name":"Francisco dos Santos","orcid":"https://orcid.org/0000-0002-2046-2742","observed_orcids":["https://orcid.org/0000-0002-2046-2742"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Francisco dos Santos","raw_affiliation_strings":["Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100890528","display_name":"Pedro Z. Andrade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Z. Andrade","raw_affiliation_strings":["IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056108053","display_name":"Joana S. Boura","orcid":"https://orcid.org/0000-0002-6026-197X","observed_orcids":["https://orcid.org/0000-0002-6026-197X"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana S. Boura","raw_affiliation_strings":["IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108519372","display_name":"Manuel M. Abecasis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Manuel M. Abecasis","raw_affiliation_strings":["Instituto Portugue\u0302s de Oncologia de Lisboa, Francisco Gentil (IPOFG), E.P.E., Lisboa, Portugal","Instituto Portugu\u00eas de Oncologia de Lisboa, Francisco Gentil (IPOFG), E.P.E., Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Portugue\u0302s de Oncologia de Lisboa, Francisco Gentil (IPOFG), E.P.E., Lisboa, Portugal","institution_ids":["https://openalex.org/I4210103180"]},{"raw_affiliation_string":"Instituto Portugu\u00eas de Oncologia de Lisboa, Francisco Gentil (IPOFG), E.P.E., Lisboa, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060339975","display_name":"Claudia Lobato da Silva","orcid":"https://orcid.org/0000-0002-1091-7651","observed_orcids":["https://orcid.org/0000-0002-1091-7651"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cl\u00e1udia Lobato da Silva","raw_affiliation_strings":["IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007145023","display_name":"Joaquim M. S. Cabral","orcid":"https://orcid.org/0000-0002-2405-5845","observed_orcids":["https://orcid.org/0000-0002-2405-5845"]},"institutions":[{"id":"https://openalex.org/I4210167387","display_name":"Institute for Biotechnology and Bioengineering","ror":"https://ror.org/05ws8g470","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210167387"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Joaquim M.S. Cabral","raw_affiliation_strings":["IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Te\u0301cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]},{"raw_affiliation_string":"IBB - Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior T\u00e9cnico, Lisboa, Portugal","institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007145023"],"corresponding_institution_ids":["https://openalex.org/I4210167387","https://openalex.org/I4387152517"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":5.9611,"has_fulltext":false,"cited_by_count":329,"citation_normalized_percentile":{"value":0.97512864,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"223","issue":"1","first_page":"27","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9520000219345093},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.753000020980835},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cell-proliferation-kinetics","display_name":"cell proliferation kinetics","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-division-kinetics","display_name":"cell division kinetics","score":0.5929999947547913},{"id":"https://openalex.org/keywords/pkh26-labeling","display_name":"PKH26 labeling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cfu-f","display_name":"CFU-F","score":0.8930000066757202},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.8529999852180481},{"id":"https://openalex.org/keywords/differentiation-potential","display_name":"differentiation potential","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nutrient-consumption","display_name":"nutrient consumption","score":0.5410000085830688},{"id":"https://openalex.org/keywords/inhibitory-metabolites","display_name":"inhibitory metabolites","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7333309650421143},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.7316209077835083},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.5898621678352356},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5824652910232544},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5650613307952881},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5533690452575684},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5270305275917053},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5264720916748047},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5152032971382141},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4959002435207367},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45286083221435547},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.44516628980636597},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3461507558822632},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2892066240310669},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26211243867874146},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.13520297408103943},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10431423783302307},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10293367505073547},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06626465916633606},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.21987","doi":"https://doi.org/10.1002/jcp.21987","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.21987","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:20020504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20020504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330264","display_name":"MIT Portugal","ror":null},{"id":"https://openalex.org/F4320330265","display_name":"Associa\u00e7\u00e3o Portuguesa Contra a Leucemia","ror":"https://ror.org/05r4c0z09"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1237020786","https://openalex.org/W1804670053","https://openalex.org/W1965738390","https://openalex.org/W1967366984","https://openalex.org/W1974989261","https://openalex.org/W1985647009","https://openalex.org/W1998461585","https://openalex.org/W2002320509","https://openalex.org/W2010618607","https://openalex.org/W2019101681","https://openalex.org/W2024682108","https://openalex.org/W2025371271","https://openalex.org/W2033284503","https://openalex.org/W2035040282","https://openalex.org/W2035176325","https://openalex.org/W2042513876","https://openalex.org/W2052898286","https://openalex.org/W2054727711","https://openalex.org/W2054814854","https://openalex.org/W2066954473","https://openalex.org/W2070773381","https://openalex.org/W2074185930","https://openalex.org/W2078266417","https://openalex.org/W2078561983","https://openalex.org/W2082690970","https://openalex.org/W2082781093","https://openalex.org/W2083123206","https://openalex.org/W2087578260","https://openalex.org/W2089037485","https://openalex.org/W2092929403","https://openalex.org/W2097259163","https://openalex.org/W2100404939","https://openalex.org/W2135210803","https://openalex.org/W2141872401","https://openalex.org/W2155243243"],"related_works":["https://openalex.org/W2591717855","https://openalex.org/W2143451025","https://openalex.org/W2888145523","https://openalex.org/W2511759555","https://openalex.org/W828175502","https://openalex.org/W2361621895","https://openalex.org/W7097502429","https://openalex.org/W2111231523","https://openalex.org/W2894191804","https://openalex.org/W2352612728"],"abstract_inverted_index":{"The":[0],"low":[1,24,96,150,173],"bone":[2],"marrow":[3],"(BM)":[4],"MSC":[5,40,47,69,147,202,215],"titers":[6],"demand":[7],"a":[8,100,130,211],"fast":[9],"ex":[10],"vivo":[11],"expansion":[12,216],"process":[13],"to":[14,22,122,142,221,225],"meet":[15],"the":[16,23,33,78,160,166,242],"clinically":[17],"relevant":[18],"cell":[19,62,83,133,245],"dosage.":[20],"Attending":[21],"oxygen":[25,151],"tension":[26,152],"of":[27,35,60,77,128,157,169,179,190,229,244],"BM":[28,39,46,68,146,201,214],"in":[29,58,99,159,183,237,249],"vivo,":[30],"we":[31],"studied":[32],"influence":[34],"hypoxia":[36,72,108],"on":[37],"human":[38],"proliferation":[41],"kinetics":[42,64],"and":[43,52,65,82,145,205,232],"metabolism.":[44],"Human":[45],"cultured":[48],"under":[49,71,95,107,139,149,172],"2%":[50,140,194,218],"(hypoxia)":[51],"20%":[53,143],"O(2)":[54,144,174,195],"(normoxia)":[55],"were":[56,92],"characterized":[57],"terms":[59],"proliferation,":[61],"division":[63,231],"metabolic":[66],"patterns.":[67],"cultures":[70],"displayed":[73,153],"an":[74,226,235],"early":[75,182],"start":[76,228],"exponential":[79],"growth":[80],"phase,":[81],"numbers":[84],"obtained":[85],"at":[86,217],"each":[87],"time":[88],"point":[89],"throughout":[90],"culture":[91],"consistently":[93,154],"higher":[94,101,132,155,176],"O(2),":[97,219],"resulting":[98],"fold":[102],"increase":[103,236],"after":[104,125],"12":[105],"days":[106,127],"(40":[109],"+/-":[110,114],"10":[111],"vs.":[112],"30":[113],"6).":[115],"Cell":[116],"labeling":[117],"with":[118,186],"PKH26":[119],"allowed":[120],"us":[121],"determine":[123],"that":[124],"2":[126],"culture,":[129,184],"significant":[131],"number":[134],"was":[135],"already":[136],"actively":[137],"dividing":[138],"compared":[141,220],"expanded":[148],"percentages":[156],"cells":[158],"latest":[161],"generations":[162],"(generations":[163],"4-6)":[164],"until":[165],"5th":[167],"day":[168],"culture.":[170],"Cells":[171],"presented":[175],"specific":[177,188],"consumption":[178],"nutrients,":[180],"especially":[181],"but":[185],"lower":[187],"production":[189],"inhibitory":[191],"metabolites.":[192],"Moreover,":[193],"favored":[196],"CFU-F":[197],"expansion,":[198],"while":[199],"maintaining":[200],"characteristic":[203],"immunophenotype":[204],"differentiative":[206],"potential.":[207],"Our":[208],"results":[209],"demonstrated":[210],"more":[212],"efficient":[213],"normoxic":[222],"conditions,":[223],"associated":[224],"earlier":[227],"cellular":[230,238],"supported":[233],"by":[234],"metabolism":[239],"efficiency":[240],"towards":[241],"maximization":[243],"yield":[246],"for":[247],"application":[248],"clinical":[250],"settings.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":22},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":30},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}