{"id":"https://openalex.org/W2007372833","doi":"https://doi.org/10.1021/bi001916l","title":"Stability, Folding, Dimerization, and Assembly Properties of the Yeast Prion Ure2p","display_name":"Stability, Folding, Dimerization, and Assembly Properties of the Yeast Prion Ure2p","publication_year":2001,"publication_date":"2001-01-19","ids":{"openalex":"https://openalex.org/W2007372833","doi":"https://doi.org/10.1021/bi001916l","mag":"2007372833","pmid":"https://pubmed.ncbi.nlm.nih.gov/11327838"},"language":"en","primary_location":{"id":"doi:10.1021/bi001916l","doi":"https://doi.org/10.1021/bi001916l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi001916l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015310040","display_name":"Carine Thual","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Carine Thual","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088362192","display_name":"Luc Bousset","orcid":"https://orcid.org/0000-0002-0433-4337","observed_orcids":["https://orcid.org/0000-0002-0433-4337"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Luc Bousset","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025432010","display_name":"Anton A. Komar","orcid":"https://orcid.org/0000-0003-4188-0633","observed_orcids":["https://orcid.org/0000-0003-4188-0633"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Anton A. Komar","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stefan Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Stefan Walter","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074839515","display_name":"Johannes B\u00fcchner","orcid":"https://orcid.org/0000-0003-1282-7737","observed_orcids":["https://orcid.org/0000-0003-1282-7737"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Johannes Buchner","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035853287","display_name":"Christophe Cullin","orcid":"https://orcid.org/0000-0003-4110-4677","observed_orcids":["https://orcid.org/0000-0003-4110-4677"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Christophe Cullin","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084373973","display_name":"Ronald Melki","orcid":"https://orcid.org/0000-0003-0000-7096","observed_orcids":["https://orcid.org/0000-0003-0000-7096"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210099362","display_name":"Laboratoire d'Enzymologie et Biochimie Structurales","ror":"https://ror.org/00j1y9t40","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210096427","https://openalex.org/I4210099362"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","FR"],"is_corresponding":true,"raw_author_name":"Ronald Melki","raw_affiliation_strings":["Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Enzymologie et Biochimie Structurales and Centre de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France, and Institut fuer Organische Chemie und Biochemie, Technische Universitaet Muenchen, D-85747 Garching, Germany","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084373973"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210099362","https://openalex.org/I4210159560","https://openalex.org/I62916508"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.789,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.91151552,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"6","first_page":"1764","last_page":"1773"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.8324999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.15940000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ure2p","display_name":"Ure2p","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ure3-prion","display_name":"[URE3] prion","score":0.8500000238418579},{"id":"https://openalex.org/keywords/yeast-prions","display_name":"yeast prions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.7400000095367432},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.8309999704360962},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/protein-unfolding-intermediates","display_name":"unfolding intermediates","score":0.734000027179718},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.6909999847412109},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.8370000123977661},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.8140000104904175},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.5059999823570251},{"id":"https://openalex.org/keywords/tryptophan-residues","display_name":"tryptophan residues","score":0.6230000257492065},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6179360151290894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5920282602310181},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5851942300796509},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5197564959526062},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5057647228240967},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4741515517234802},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.45325005054473877},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.44550198316574097},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.44012024998664856},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.4166392683982849},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4163891673088074},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32967767119407654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20577943325042725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi001916l","doi":"https://doi.org/10.1021/bi001916l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi001916l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:11327838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11327838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1884821406","https://openalex.org/W1965761417","https://openalex.org/W1999789499","https://openalex.org/W2025211528","https://openalex.org/W2032015542","https://openalex.org/W2059821314","https://openalex.org/W2090869924","https://openalex.org/W2146653841","https://openalex.org/W2155894308","https://openalex.org/W2167591025","https://openalex.org/W4230594022","https://openalex.org/W4244779656"],"related_works":["https://openalex.org/W4213252678","https://openalex.org/W2090590635","https://openalex.org/W7064345351","https://openalex.org/W2159488630","https://openalex.org/W1994373083","https://openalex.org/W2760892028","https://openalex.org/W1965212214","https://openalex.org/W1984674965","https://openalex.org/W2146229280","https://openalex.org/W2105740620"],"abstract_inverted_index":{"The":[0,24],"[URE3]":[1],"factor":[2],"of":[3,16,19,27,30,48,91,97,116,145,180,194,220,225,248,259],"Saccharomyces":[4],"cerevisiae":[5],"propagates":[6],"by":[7,88],"a":[8,149,221,257],"prion-like":[9],"mechanism":[10],"and":[11,42,53,104,119,185,188,199,245,250],"corresponds":[12],"to":[13,66,106,172,212],"the":[14,17,20,28,45,49,85,94,98,114,136,143,146,181,189,213,218,230,239,243,251],"loss":[15],"function":[18],"cellular":[21],"protein":[22,50,147,231],"Ure2.":[23],"molecular":[25],"basis":[26],"propagation":[29],"this":[31,177],"phenotype":[32],"is":[33,51,59,139],"unknown.":[34],"We":[35,122,132],"recently":[36],"expressed":[37],"Ure2p":[38,62,92,117,126,158,200,205,226,249],"in":[39,64,93,166,256],"Escherichia":[40],"coli":[41],"demonstrated":[43],"that":[44,70,125,135,152,160,204],"N-terminal":[46,137,168,206],"region":[47,58,138],"flexible":[52],"unstructured,":[54],"while":[55],"its":[56,101,129,167],"C-terminal":[57,120,130,201,246],"compactly":[60],"folded.":[61],"oligomerizes":[63],"solution":[65],"form":[67],"mainly":[68],"dimers":[69],"assemble":[71,107],"into":[72,108,148,233],"fibrils":[73],"[Thual":[74],"et":[75],"al.":[76],"(1999)":[77],"J.":[78],"Biol.":[79],"Chem.":[80],"274,":[81],"13666-13674].":[82],"To":[83],"determine":[84],"role":[86],"played":[87],"each":[89],"domain":[90,207],"overall":[95,182],"properties":[96,115],"protein,":[99],"specifically,":[100],"stability,":[102],"conformation,":[103,183],"capacity":[105],"fibrils,":[109],"we":[110],"have":[111],"further":[112],"analyzed":[113],"N-":[118,244],"regions.":[121],"show":[123,134],"here":[124],"dimerizes":[127],"through":[128],"region.":[131],"also":[133],"essential":[140],"for":[141],"directing":[142],"assembly":[144],"particular":[150],"pathway":[151],"yields":[153],"amyloid":[154,234],"fibrils.":[155,235],"A":[156],"full-length":[157,195],"variant":[159],"possesses":[161],"an":[162],"additional":[163,210],"tryptophan":[164],"residue":[165],"moiety":[169],"was":[170],"generated":[171],"follow":[173],"conformational":[174],"changes":[175],"affecting":[176],"domain.":[178],"Comparison":[179],"folding,":[184],"unfolding":[186,223,253],"properties,":[187],"behavior":[190],"upon":[191],"proteolytic":[192],"treatments":[193],"Ure2p,":[196],"Ure2pW37":[197],"variant,":[198],"fragment":[202],"reveals":[203,217],"confers":[208],"no":[209],"stability":[211],"protein.":[214],"This":[215],"study":[216],"existence":[219],"stable":[222],"intermediate":[224],"under":[227],"conditions":[228],"where":[229],"assembles":[232],"Our":[236],"results":[237],"contradict":[238],"intramolecular":[240],"interaction":[241],"between":[242],"moieties":[247],"single":[252],"transitions":[254],"reported":[255],"number":[258],"previous":[260],"studies.":[261]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
