{"id":"https://openalex.org/W2007364207","doi":"https://doi.org/10.1128/jb.01223-13","title":"Physiological Framework for the Regulation of Quorum Sensing-Dependent Public Goods in Pseudomonas aeruginosa","display_name":"Physiological Framework for the Regulation of Quorum Sensing-Dependent Public Goods in Pseudomonas aeruginosa","publication_year":2013,"publication_date":"2013-12-28","ids":{"openalex":"https://openalex.org/W2007364207","doi":"https://doi.org/10.1128/jb.01223-13","mag":"2007364207","pmid":"https://pubmed.ncbi.nlm.nih.gov/24375105","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3957720"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01223-13","doi":"https://doi.org/10.1128/jb.01223-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01223-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1155.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jb.asm.org/content/jb/196/6/1155.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014613469","display_name":"Brett L. Mellbye","orcid":"https://orcid.org/0000-0002-3586-1885","observed_orcids":["https://orcid.org/0000-0002-3586-1885"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brett Mellbye","raw_affiliation_strings":["Department of Microbiology and Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011858015","display_name":"Mart\u00edn Schuster","orcid":"https://orcid.org/0000-0002-7674-0887","observed_orcids":["https://orcid.org/0000-0002-7674-0887"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Schuster","raw_affiliation_strings":["Department of Microbiology and Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon, USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":null,"apc_paid":null,"fwci":3.5817,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.93691728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"196","issue":"6","first_page":"1155","last_page":"1164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11578","display_name":"Plant Pathogenic Bacteria Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"quorum sensing","score":0.9869999885559082},{"id":"https://openalex.org/keywords/public-goods","display_name":"public goods","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nutrient-limitation","display_name":"nutrient limitation","score":0.6940000057220459},{"id":"https://openalex.org/keywords/extracellular-enzyme-secretion","display_name":"extracellular enzyme secretion","score":0.6859999895095825},{"id":"https://openalex.org/keywords/biofilm","display_name":"biofilm","score":0.4410000145435333},{"id":"https://openalex.org/keywords/starvation-response","display_name":"starvation response","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cell-density","display_name":"cell density","score":0.3659999966621399},{"id":"https://openalex.org/keywords/chemostat-culture","display_name":"chemostat culture","score":0.6330000162124634},{"id":"https://openalex.org/keywords/opportunistic-pathogens","display_name":"opportunistic pathogens","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.8461951017379761},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8210207223892212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8209307193756104},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.7738829255104065},{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.5834733843803406},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5344796180725098},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5182552337646484},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.461099237203598},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.44135814905166626},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.42482486367225647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30803656578063965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21897703409194946},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18364164233207703},{"id":"https://openalex.org/C2993175405","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Bacterial protein","level":3,"score":0.14206594228744507}],"mesh":[{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056265","descriptor_name":"Microbial Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.01223-13","doi":"https://doi.org/10.1128/jb.01223-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01223-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1155.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3957720","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3957720","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:24375105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24375105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jb.01223-13","doi":"https://doi.org/10.1128/jb.01223-13","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.01223-13","pdf_url":"https://jb.asm.org/content/jb/196/6/1155.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6324938129","display_name":"Collaborative research: Short-circuiting in bacterial quorum sensing","funder_award_id":"1158553","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6982399945","display_name":null,"funder_award_id":"AI079454","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8164402575","display_name":"Stringent control of virulence gene expression in Pseudomonas aeruginosa","funder_award_id":"R21AI079454","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007364207.pdf","grobid_xml":"https://content.openalex.org/works/W2007364207.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1123885646","https://openalex.org/W1515227419","https://openalex.org/W1548309673","https://openalex.org/W1555657499","https://openalex.org/W1600715779","https://openalex.org/W1781531090","https://openalex.org/W1807136536","https://openalex.org/W1834101661","https://openalex.org/W1891685870","https://openalex.org/W1903990541","https://openalex.org/W1963529527","https://openalex.org/W1967221794","https://openalex.org/W1973430111","https://openalex.org/W1977105094","https://openalex.org/W1979280650","https://openalex.org/W1980352067","https://openalex.org/W1983455597","https://openalex.org/W1999073796","https://openalex.org/W2009469402","https://openalex.org/W2020486543","https://openalex.org/W2029139718","https://openalex.org/W2055294982","https://openalex.org/W2061972317","https://openalex.org/W2063792498","https://openalex.org/W2077761969","https://openalex.org/W2087371604","https://openalex.org/W2092445198","https://openalex.org/W2093514941","https://openalex.org/W2104926939","https://openalex.org/W2106758768","https://openalex.org/W2113720531","https://openalex.org/W2113771246","https://openalex.org/W2118260061","https://openalex.org/W2118413309","https://openalex.org/W2120468912","https://openalex.org/W2122094987","https://openalex.org/W2124152757","https://openalex.org/W2126739060","https://openalex.org/W2127539199","https://openalex.org/W2131869707","https://openalex.org/W2134202561","https://openalex.org/W2137215017","https://openalex.org/W2138785360","https://openalex.org/W2142814460","https://openalex.org/W2144562098","https://openalex.org/W2145085268","https://openalex.org/W2148329905","https://openalex.org/W2150417163","https://openalex.org/W2157927045","https://openalex.org/W2159010530","https://openalex.org/W2166134293","https://openalex.org/W2166816492","https://openalex.org/W2168755417","https://openalex.org/W2170792798","https://openalex.org/W2484870474"],"related_works":["https://openalex.org/W7098972477","https://openalex.org/W3033486995","https://openalex.org/W2166345625","https://openalex.org/W2008092459","https://openalex.org/W2791843751","https://openalex.org/W2109942408","https://openalex.org/W1583614303","https://openalex.org/W7097318579","https://openalex.org/W4362601522","https://openalex.org/W7096947441"],"abstract_inverted_index":{"Many":[0],"bacteria":[1],"possess":[2],"cell":[3,85],"density-dependent":[4],"quorum-sensing":[5],"(QS)":[6],"systems":[7,215,227],"that":[8,169,188],"often":[9],"regulate":[10],"cooperative":[11,177],"secretions":[12],"involved":[13],"in":[14,42,207,228],"host-microbe":[15],"or":[16,21],"microbe-microbe":[17],"interactions.":[18],"These":[19],"secretions,":[20],"\"public":[22],"goods,\"":[23],"are":[24],"frequently":[25],"coregulated":[26],"by":[27,74,118,201],"stress":[28],"and":[29,51,70,77,94,127,155,173,191,193,213],"starvation":[30,218],"responses.":[31],"Here":[32],"we":[33,54],"provide":[34],"a":[35,105,150,161],"physiological":[36],"rationale":[37],"for":[38,64,184],"such":[39],"regulatory":[40],"complexity":[41],"the":[43,65,75,89,99,109,114,119,124,134,138,144,202,208,211,222],"opportunistic":[44],"pathogen":[45],"Pseudomonas":[46],"aeruginosa.":[47],"Using":[48],"minimal-medium":[49],"batch":[50],"chemostat":[52],"cultures,":[53],"comprehensively":[55],"characterized":[56],"specific":[57],"growth":[58,142],"rate-limiting":[59],"macronutrients":[60],"as":[61],"key":[62],"triggers":[63],"expression":[66],"of":[67,108,123,137,166,210,224],"extracellular":[68],"enzymes":[69],"metabolites":[71],"directly":[72],"controlled":[73],"las":[76,212],"rhl":[78,139,214],"QS":[79,226],"systems.":[80],"Expression":[81],"was":[82,95,102],"unrelated":[83],"to":[84,216],"density,":[86],"depended":[87],"on":[88],"secreted":[90],"product's":[91],"elemental":[92],"composition,":[93],"induced":[96],"only":[97],"when":[98],"limiting":[100],"nutrient":[101],"not":[103],"also":[104],"building":[106],"block":[107],"product;":[110],"rhl-dependent":[111],"products":[112],"showed":[113],"strongest":[115],"response,":[116],"caused":[117],"largely":[120],"las-independent":[121],"induction":[122],"regulator":[125],"RhlR":[126],"its":[128],"cognate":[129],"signal.":[130],"In":[131],"agreement":[132],"with":[133],"prominent":[135],"role":[136],"system,":[140],"slow":[141],"inverted":[143],"las-to-rhl":[145],"signal":[146],"ratio,":[147],"previously":[148],"considered":[149],"characteristic":[151],"distinguishing":[152],"between":[153],"planktonic":[154],"biofilm":[156],"lifestyles.":[157],"Our":[158],"results":[159],"highlight":[160],"supply-driven,":[162],"metabolically":[163],"prudent":[164],"regulation":[165,180],"public":[167,186],"goods":[168,187],"minimizes":[170],"production":[171],"costs":[172],"thereby":[174],"helps":[175],"stabilize":[176],"behavior.":[178],"Such":[179],"would":[181],"be":[182,198],"beneficial":[183],"QS-dependent":[185],"act":[189],"broadly":[190],"nonspecifically,":[192],"whose":[194],"need":[195],"cannot":[196],"always":[197],"accurately":[199],"assessed":[200],"producing":[203],"cell.":[204,230],"Clear":[205],"differences":[206],"capacities":[209],"integrate":[217],"signals":[219],"help":[220],"explain":[221],"existence":[223],"multiple":[225],"one":[229]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}