{"id":"https://openalex.org/W2007361697","doi":"https://doi.org/10.1371/journal.pone.0104617","title":"Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases","display_name":"Disruption of Axonal Transport Perturbs Bone Morphogenetic Protein (BMP) - Signaling and Contributes to Synaptic Abnormalities in Two Neurodegenerative Diseases","publication_year":2014,"publication_date":"2014-08-15","ids":{"openalex":"https://openalex.org/W2007361697","doi":"https://doi.org/10.1371/journal.pone.0104617","mag":"2007361697","pmid":"https://pubmed.ncbi.nlm.nih.gov/25127478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4134223"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0104617","doi":"https://doi.org/10.1371/journal.pone.0104617","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0104617","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104617&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104617&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029825934","display_name":"Min\u2010Jung Kang","orcid":"https://orcid.org/0000-0002-1398-2037","observed_orcids":["https://orcid.org/0000-0002-1398-2037"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Jung Kang","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Timothy J. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Hansen","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057968507","display_name":"Monique Mickiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique Mickiewicz","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024914930","display_name":"Tadeusz J. Kaczynski","orcid":"https://orcid.org/0000-0002-1959-7420","observed_orcids":["https://orcid.org/0000-0002-1959-7420"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tadeusz J. Kaczynski","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111269375","display_name":"Samantha Fye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Fye","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022667013","display_name":"Shermali Gunawardena","orcid":"https://orcid.org/0000-0001-8776-9397","observed_orcids":["https://orcid.org/0000-0001-8776-9397"]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shermali Gunawardena","raw_affiliation_strings":["Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America","institution_ids":["https://openalex.org/I63190737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5022667013"],"corresponding_institution_ids":["https://openalex.org/I63190737"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.9137,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.68659243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"8","first_page":"e104617","last_page":"e104617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.17479999363422394,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.17479999363422394,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.15629999339580536,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.14810000360012054,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axonal-transport","display_name":"axonal transport","score":1.0},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kinesin-1","display_name":"kinesin-1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/dynein-motor","display_name":"dynein motor","score":0.921999990940094},{"id":"https://openalex.org/keywords/synaptic-abnormalities","display_name":"synaptic abnormalities","score":0.718999981880188},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/polyglutamine-expansion","display_name":"polyglutamine expansion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/app770","display_name":"APP770","score":0.574999988079071},{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.953000009059906},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.6729999780654907},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.9279999732971191}],"concepts":[{"id":"https://openalex.org/C59006786","wikidata":"https://www.wikidata.org/wiki/Q15319390","display_name":"Kinesin","level":3,"score":0.7974599599838257},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7531896829605103},{"id":"https://openalex.org/C70192387","wikidata":"https://www.wikidata.org/wiki/Q792602","display_name":"Axoplasmic transport","level":2,"score":0.7248232960700989},{"id":"https://openalex.org/C106987784","wikidata":"https://www.wikidata.org/wiki/Q410134","display_name":"Dynein","level":3,"score":0.6717353463172913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6130861043930054},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5617562532424927},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4724334180355072},{"id":"https://openalex.org/C194082555","wikidata":"https://www.wikidata.org/wiki/Q7317034","display_name":"Retrograde signaling","level":3,"score":0.4329168200492859},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.41842421889305115},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.2510092258453369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1509546935558319},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.08689549565315247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001370","descriptor_name":"Axonal Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001370","descriptor_name":"Axonal Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004398","descriptor_name":"Dyneins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016547","descriptor_name":"Kinesins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0104617","doi":"https://doi.org/10.1371/journal.pone.0104617","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0104617","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104617&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3105605","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4134223","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4134223","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4134223","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25127478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25127478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.793.5901","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.793.5901","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1f/06/pone.0104617.PMC4134223.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ce226dc0f9564274b3c7ff28601e4546","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ce226dc0f9564274b3c7ff28601e4546","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 8, p e104617 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1140970","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Disruption_of_Axonal_Transport_Perturbs_Bone_Morphogenetic_Protein_BMP_Signaling_and_Contributes_to_Synaptic_Abnormalities_in_Two_Neurodegenerative_Diseases_/1140970","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0104617","doi":"https://doi.org/10.1371/journal.pone.0104617","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0104617","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0104617&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4272338869","display_name":"Dissecting the in vivo role of Huntingtin in Rab vesicle movement on microtubules","funder_award_id":"R03NS084386","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5942552551","display_name":null,"funder_award_id":"R03-NS084386-01","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306461","display_name":"John R. Oishei Foundation","ror":"https://ror.org/05jj8cx84"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"},{"id":"https://openalex.org/F4320333441","display_name":"Center for Undergraduate Research and Scholarship, Bowling Green State University","ror":null},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007361697.pdf","grobid_xml":"https://content.openalex.org/works/W2007361697.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W14527431","https://openalex.org/W189704854","https://openalex.org/W1521104469","https://openalex.org/W1525752116","https://openalex.org/W1587740805","https://openalex.org/W1877780738","https://openalex.org/W1915770046","https://openalex.org/W1917414302","https://openalex.org/W1964408858","https://openalex.org/W1967541860","https://openalex.org/W1968683040","https://openalex.org/W1976075952","https://openalex.org/W1976787877","https://openalex.org/W1979904143","https://openalex.org/W1985474993","https://openalex.org/W1988596534","https://openalex.org/W1993100924","https://openalex.org/W1993308396","https://openalex.org/W1994099986","https://openalex.org/W1997955557","https://openalex.org/W2001428953","https://openalex.org/W2005735676","https://openalex.org/W2007009180","https://openalex.org/W2007788777","https://openalex.org/W2011381918","https://openalex.org/W2015605553","https://openalex.org/W2020808982","https://openalex.org/W2021981560","https://openalex.org/W2024984804","https://openalex.org/W2026899274","https://openalex.org/W2027457931","https://openalex.org/W2029120000","https://openalex.org/W2031838837","https://openalex.org/W2033180366","https://openalex.org/W2036734848","https://openalex.org/W2038334571","https://openalex.org/W2039091783","https://openalex.org/W2043773978","https://openalex.org/W2044213360","https://openalex.org/W2044594834","https://openalex.org/W2044643509","https://openalex.org/W2044778355","https://openalex.org/W2052624827","https://openalex.org/W2053716435","https://openalex.org/W2053935303","https://openalex.org/W2054538738","https://openalex.org/W2055444332","https://openalex.org/W2055889984","https://openalex.org/W2056020456","https://openalex.org/W2056313099","https://openalex.org/W2057306734","https://openalex.org/W2062535587","https://openalex.org/W2062656302","https://openalex.org/W2065384834","https://openalex.org/W2067886421","https://openalex.org/W2068732123","https://openalex.org/W2073374252","https://openalex.org/W2079587293","https://openalex.org/W2089129818","https://openalex.org/W2090948229","https://openalex.org/W2091260402","https://openalex.org/W2092542548","https://openalex.org/W2093687422","https://openalex.org/W2099198611","https://openalex.org/W2106440279","https://openalex.org/W2107015337","https://openalex.org/W2109254664","https://openalex.org/W2109727228","https://openalex.org/W2110341842","https://openalex.org/W2110715131","https://openalex.org/W2113451695","https://openalex.org/W2114640601","https://openalex.org/W2116449089","https://openalex.org/W2116670858","https://openalex.org/W2118694086","https://openalex.org/W2124813164","https://openalex.org/W2125635130","https://openalex.org/W2129645512","https://openalex.org/W2131176843","https://openalex.org/W2133361341","https://openalex.org/W2133378263","https://openalex.org/W2133411939","https://openalex.org/W2133532794","https://openalex.org/W2139239806","https://openalex.org/W2141851583","https://openalex.org/W2144086073","https://openalex.org/W2144368413","https://openalex.org/W2150009705","https://openalex.org/W2153954651","https://openalex.org/W2160505936","https://openalex.org/W2161307536","https://openalex.org/W2162229008","https://openalex.org/W2166723435","https://openalex.org/W2168583567","https://openalex.org/W2171776741","https://openalex.org/W4231042049"],"related_works":["https://openalex.org/W2065384834","https://openalex.org/W2072902545","https://openalex.org/W2133532794","https://openalex.org/W2901176125","https://openalex.org/W2078517367","https://openalex.org/W2033996829","https://openalex.org/W7030546818","https://openalex.org/W1995331422","https://openalex.org/W1989287464","https://openalex.org/W4255803436"],"abstract_inverted_index":{"Formation":[0],"of":[1,6,12,36,74,125,157,187],"new":[2],"synapses":[3,8],"or":[4,99],"maintenance":[5,33],"existing":[7],"requires":[9],"the":[10,16,19,37,43,75,126,203,233],"delivery":[11],"synaptic":[13,138,188,193,234],"components":[14,73,124],"from":[15],"soma":[17],"to":[18,121,202,232],"nerve":[20],"termini":[21],"via":[22],"axonal":[23,55,177,222],"transport.":[24],"One":[25],"pathway":[26,77],"that":[27,52,72,200,211],"is":[28,42],"important":[29],"in":[30,54,97,116,123,149,221,237],"synapse":[31],"formation,":[32],"and":[34,83,131,144,161,192,229],"function":[35],"Drosophila":[38],"neuromuscular":[39],"junction":[40],"(NMJ)":[41],"bone":[44],"morphogenetic":[45],"protein":[46,134,165],"(BMP)-signaling":[47],"pathway.":[48],"Here":[49],"we":[50],"show":[51],"perturbations":[53],"transport":[56,178,223],"directly":[57,212],"disrupt":[58],"BMP":[59,76,127,208,227],"signaling,":[60,228],"as":[61],"measured":[62],"by":[63,95],"its":[64],"downstream":[65],"signal,":[66],"phospho":[67],"Mad":[68],"(p-Mad).":[69],"We":[70],"found":[71],"genetically":[78],"interact":[79],"with":[80,167,176,214],"both":[81,129],"kinesin-1":[82,98,110,130],"dynein":[84,100,103,132],"motor":[85,133],"proteins.":[86],"Thick":[87],"vein":[88],"(TKV)":[89],"vesicle":[90],"motility":[91,143],"was":[92],"also":[93,136],"perturbed":[94],"reductions":[96],"motors.":[101],"Interestingly,":[102],"mutations":[104],"severely":[105],"disrupted":[106,148],"p-Mad":[107,117,145],"signaling":[108,146,205,209],"while":[109],"mutants":[111,122,135],"showed":[112,137,185],"a":[113,168,207],"mild":[114],"reduction":[115],"signal":[118],"intensity.":[119],"Similar":[120],"pathway,":[128],"morphological":[139],"defects.":[140],"Strikingly":[141],"TKV":[142],"were":[147],"larvae":[150,180],"expressing":[151,181],"two":[152,239],"human":[153,162],"disease":[154,171,183],"proteins;":[155],"expansions":[156],"glutamine":[158],"repeats":[159],"(polyQ77)":[160],"amyloid":[163],"precursor":[164],"(APP)":[166],"familial":[169],"Alzheimer's":[170],"(AD)":[172],"mutation":[173],"(APPswe).":[174],"Consistent":[175],"defects,":[179],"these":[182,238],"proteins":[184,189],"accumulations":[186],"along":[190],"axons":[191],"abnormalities.":[194],"Taken":[195],"together":[196],"our":[197],"results":[198],"suggest":[199],"similar":[201],"NGF-TrkA":[204],"endosome,":[206],"endosome":[210],"interacts":[213],"molecular":[215],"motors":[216],"likely":[217,230],"exist.":[218],"Thus":[219],"problems":[220],"occurs":[224],"early,":[225],"perturbs":[226],"contributes":[231],"abnormalities":[235],"observed":[236],"diseases.":[240]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
