{"id":"https://openalex.org/W2007360324","doi":"https://doi.org/10.1016/0041-008x(71)90265-1","title":"The comparative acute toxicity of two cardiac glycosides in adult and newborn rats","display_name":"The comparative acute toxicity of two cardiac glycosides in adult and newborn rats","publication_year":1971,"publication_date":"1971-12-01","ids":{"openalex":"https://openalex.org/W2007360324","doi":"https://doi.org/10.1016/0041-008x(71)90265-1","mag":"2007360324","pmid":"https://pubmed.ncbi.nlm.nih.gov/5169073"},"language":"en","primary_location":{"id":"doi:10.1016/0041-008x(71)90265-1","doi":"https://doi.org/10.1016/0041-008x(71)90265-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(71)90265-1","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103548077","display_name":"William J. Scott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.J. Scott","raw_affiliation_strings":["Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","Woodard Research Corporation, Herndon, Virginia 22070 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","institution_ids":[]},{"raw_affiliation_string":"Woodard Research Corporation, Herndon, Virginia 22070 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062360453","display_name":"Robert Pryor Beliles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R.P. Beliles","raw_affiliation_strings":["Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","Woodard Research Corporation, Herndon, Virginia 22070 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","institution_ids":[]},{"raw_affiliation_string":"Woodard Research Corporation, Herndon, Virginia 22070 USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110007538","display_name":"H.I. Silverman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H.I. Silverman","raw_affiliation_strings":["Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","Woodard Research Corporation, Herndon, Virginia 22070 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Knoll Pharmaceutical Company, Orange, New Jersey 07051 USA","institution_ids":[]},{"raw_affiliation_string":"Woodard Research Corporation, Herndon, Virginia 22070 USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.8709,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72591823,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"20","issue":"4","first_page":"599","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.24330000579357147,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.24330000579357147,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.1527000069618225,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.13259999454021454,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-glycosides","display_name":"cardiac glycosides","score":0.9890000224113464},{"id":"https://openalex.org/keywords/digitoxin","display_name":"digitoxin","score":0.9700000286102295},{"id":"https://openalex.org/keywords/proscillaridin","display_name":"proscillaridin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.5759999752044678},{"id":"https://openalex.org/keywords/neonatal-rats","display_name":"neonatal rats","score":0.828000009059906},{"id":"https://openalex.org/keywords/sex-differences-in-toxicity","display_name":"sex differences in toxicity","score":0.7979999780654907},{"id":"https://openalex.org/keywords/intestinal-absorption","display_name":"intestinal absorption","score":0.8199999928474426},{"id":"https://openalex.org/keywords/ld50","display_name":"LD50","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2780628665","wikidata":"https://www.wikidata.org/wiki/Q423890","display_name":"Digitoxin","level":4,"score":0.9773249626159668},{"id":"https://openalex.org/C194671627","wikidata":"https://www.wikidata.org/wiki/Q192639","display_name":"Glycoside","level":2,"score":0.8314998149871826},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.755828857421875},{"id":"https://openalex.org/C2780557390","wikidata":"https://www.wikidata.org/wiki/Q422238","display_name":"Cardiac glycoside","level":4,"score":0.6786791086196899},{"id":"https://openalex.org/C2909353472","wikidata":"https://www.wikidata.org/wiki/Q156533","display_name":"DIGITALIS GLYCOSIDES","level":4,"score":0.5109735727310181},{"id":"https://openalex.org/C2908711114","wikidata":"https://www.wikidata.org/wiki/Q151350","display_name":"Digitalis Toxicity","level":4,"score":0.4437786340713501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4356689155101776},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.4207504391670227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3990624248981476},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39554569125175476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39356666803359985},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36316990852355957},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3223607540130615},{"id":"https://openalex.org/C2776445394","wikidata":"https://www.wikidata.org/wiki/Q156533","display_name":"Digitalis","level":3,"score":0.18137475848197937},{"id":"https://openalex.org/C2777707475","wikidata":"https://www.wikidata.org/wiki/Q422222","display_name":"Digoxin","level":3,"score":0.16310733556747437},{"id":"https://openalex.org/C2779133857","wikidata":"https://www.wikidata.org/wiki/Q285911","display_name":"Ouabain","level":3,"score":0.10203090310096741},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.05919727683067322},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.05413749814033508},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002018","descriptor_name":"Bufanolides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004071","descriptor_name":"Digitalis Glycosides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D004074","descriptor_name":"Digitoxin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007928","descriptor_name":"Lethal Dose 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0041-008x(71)90265-1","doi":"https://doi.org/10.1016/0041-008x(71)90265-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0041-008x(71)90265-1","pdf_url":null,"source":{"id":"https://openalex.org/S42307217","display_name":"Toxicology and Applied Pharmacology","issn_l":"0041-008X","issn":["0041-008X","1096-0333"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Applied Pharmacology","raw_type":"journal-article"},{"id":"pmid:5169073","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5169073","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and applied pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1584083992","https://openalex.org/W1978620870","https://openalex.org/W2033967457","https://openalex.org/W2121529461","https://openalex.org/W2255008884","https://openalex.org/W2313177079","https://openalex.org/W2401188729","https://openalex.org/W2412604770","https://openalex.org/W4205953544"],"related_works":["https://openalex.org/W4251080468","https://openalex.org/W92845677","https://openalex.org/W2279972816","https://openalex.org/W18014174","https://openalex.org/W85117213","https://openalex.org/W2411802874","https://openalex.org/W2412825658","https://openalex.org/W1765753370","https://openalex.org/W1998243951","https://openalex.org/W2047655652"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}