{"id":"https://openalex.org/W2007357434","doi":"https://doi.org/10.1523/jneurosci.0109-07.2007","title":"Methylphenidate Administration to Juvenile Rats Alters Brain Areas Involved in Cognition, Motivated Behaviors, Appetite, and Stress","display_name":"Methylphenidate Administration to Juvenile Rats Alters Brain Areas Involved in Cognition, Motivated Behaviors, Appetite, and Stress","publication_year":2007,"publication_date":"2007-07-04","ids":{"openalex":"https://openalex.org/W2007357434","doi":"https://doi.org/10.1523/jneurosci.0109-07.2007","mag":"2007357434","pmid":"https://pubmed.ncbi.nlm.nih.gov/17611273","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794586"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0109-07.2007","doi":"https://doi.org/10.1523/jneurosci.0109-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0109-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/27/27/7196.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037655386","display_name":"Jason D. Gray","orcid":"https://orcid.org/0000-0001-8854-5176","observed_orcids":["https://orcid.org/0000-0001-8854-5176"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Gray","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience, Weill-Cornell Medical College, New York, New York 10021, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074566956","display_name":"Michael Punsoni","orcid":"https://orcid.org/0009-0000-5863-3327","observed_orcids":["https://orcid.org/0009-0000-5863-3327"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Punsoni","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022587440","display_name":"Nora E. Tabori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora E. Tabori","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and","Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083746806","display_name":"Jay T. Melton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay T. Melton","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046480922","display_name":"Victoria Fanslow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Fanslow","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110198113","display_name":"Mary J. Ward","orcid":"https://orcid.org/0009-0008-0312-0661","observed_orcids":["https://orcid.org/0009-0008-0312-0661"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary J. Ward","raw_affiliation_strings":["Department of Pediatrics, Weill-Cornell Medical College, New York, New York 10021,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Weill-Cornell Medical College, New York, New York 10021,","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056851685","display_name":"Bojana Zupan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bojana Zupan","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073911541","display_name":"David Menzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Menzer","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002140277","display_name":"Jackson Rice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jackson Rice","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033901531","display_name":"Carrie T. Drake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie T. Drake","raw_affiliation_strings":["Center for Human Toxicology , University of Utah , Salt Lake City , UT","Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Human Toxicology , University of Utah , Salt Lake City , UT","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004990772","display_name":"Russell D. Romeo","orcid":"https://orcid.org/0000-0001-8806-0873","observed_orcids":["https://orcid.org/0000-0001-8806-0873"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell D. Romeo","raw_affiliation_strings":["Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063809087","display_name":"Wayne G. Brake","orcid":"https://orcid.org/0000-0001-8078-1959","observed_orcids":["https://orcid.org/0000-0001-8078-1959"]},"institutions":[{"id":"https://openalex.org/I60158472","display_name":"Concordia University","ror":"https://ror.org/0420zvk78","country_code":"CA","type":"education","lineage":["https://openalex.org/I60158472"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Wayne G. Brake","raw_affiliation_strings":["Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada H4B 1R6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, Canada H4B 1R6","institution_ids":["https://openalex.org/I60158472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016332867","display_name":"Annelyn Torres-Rever\u00f3n","orcid":"https://orcid.org/0000-0003-0347-5469","observed_orcids":["https://orcid.org/0000-0003-0347-5469"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annelyn Torres-Reveron","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030629278","display_name":"Teresa A. Milner","orcid":"https://orcid.org/0000-0002-0458-6569","observed_orcids":["https://orcid.org/0000-0002-0458-6569"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Teresa A. Milner","raw_affiliation_strings":["Division of Neurobiology, Department of Neurology and Neuroscience and","Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurobiology, Department of Neurology and Neuroscience and","institution_ids":[]},{"raw_affiliation_string":"Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, and","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030629278"],"corresponding_institution_ids":["https://openalex.org/I83399316"],"apc_list":null,"apc_paid":null,"fwci":4.9229,"has_fulltext":true,"cited_by_count":114,"citation_normalized_percentile":{"value":0.94896888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"27","issue":"27","first_page":"7196","last_page":"7207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methylphenidate","display_name":"methylphenidate","score":1.0},{"id":"https://openalex.org/keywords/attention-deficit-hyperactivity-disorder","display_name":"attention deficit hyperactivity disorder","score":0.8849999904632568},{"id":"https://openalex.org/keywords/developmental-drug-exposure","display_name":"developmental drug exposure","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/norepinephrine-transporter","display_name":"norepinephrine transporter","score":0.9929999709129333},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"dentate gyrus","score":0.9179999828338623},{"id":"https://openalex.org/keywords/medial-striatum","display_name":"medial striatum","score":0.906000018119812},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.9919999837875366},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5630000233650208},{"id":"https://openalex.org/keywords/appetite","display_name":"appetite","score":0.3160000145435333},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.5659999847412109},{"id":"https://openalex.org/keywords/neurotransmitter-changes","display_name":"neurotransmitter changes","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.754430890083313},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6238026022911072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6185005307197571},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.6171199083328247},{"id":"https://openalex.org/C176233148","wikidata":"https://www.wikidata.org/wiki/Q14874257","display_name":"Norepinephrine transporter","level":4,"score":0.5890726447105408},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5830062627792358},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5389436483383179},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5086349248886108},{"id":"https://openalex.org/C122871604","wikidata":"https://www.wikidata.org/wiki/Q2248886","display_name":"Neural cell adhesion molecule","level":4,"score":0.5024616718292236},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4800911247730255},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.47350531816482544},{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.46468567848205566},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.46112436056137085},{"id":"https://openalex.org/C2777209535","wikidata":"https://www.wikidata.org/wiki/Q14864388","display_name":"Synaptophysin","level":3,"score":0.44384264945983887},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.432179719209671},{"id":"https://openalex.org/C2777112843","wikidata":"https://www.wikidata.org/wiki/Q422112","display_name":"Methylphenidate","level":3,"score":0.424147367477417},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.41267648339271545},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4001622796058655},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.36451926827430725},{"id":"https://openalex.org/C2780783007","wikidata":"https://www.wikidata.org/wiki/Q181923","display_name":"Attention deficit hyperactivity disorder","level":2,"score":0.29187947511672974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2870718836784363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.19777804613113403},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18401780724525452},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1738806962966919},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.10581573843955994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.0},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.0},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008774","descriptor_name":"Methylphenidate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.0109-07.2007","doi":"https://doi.org/10.1523/jneurosci.0109-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0109-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:6794586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6794586","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:17611273","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17611273","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0109-07.2007","doi":"https://doi.org/10.1523/jneurosci.0109-07.2007","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0109-07.2007","pdf_url":"https://www.jneurosci.org/content/jneuro/27/27/7196.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1511208199","display_name":"Experimental Neurogenic Hypertension Program","funder_award_id":"P01HL018974","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2612552963","display_name":"Stress-Opioid Interactions in Hippocampus","funder_award_id":"R01DA008259","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G7144753537","display_name":"Developmental Affects of Ritalin on Brain","funder_award_id":"R21MH063769","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000115535","display_name":null,"funder_award_id":"HL18974","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007357434.pdf","grobid_xml":"https://content.openalex.org/works/W2007357434.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W7049542","https://openalex.org/W7611090","https://openalex.org/W13893899","https://openalex.org/W171691018","https://openalex.org/W643514393","https://openalex.org/W1495907309","https://openalex.org/W1566743778","https://openalex.org/W1597328543","https://openalex.org/W1603591159","https://openalex.org/W1646726516","https://openalex.org/W1883162734","https://openalex.org/W1892379295","https://openalex.org/W1893786132","https://openalex.org/W1901042123","https://openalex.org/W1916743044","https://openalex.org/W1920452455","https://openalex.org/W1964565474","https://openalex.org/W1972736369","https://openalex.org/W1973337674","https://openalex.org/W1977634040","https://openalex.org/W1978153650","https://openalex.org/W1982070625","https://openalex.org/W1983985508","https://openalex.org/W1985645482","https://openalex.org/W1986520615","https://openalex.org/W1988152811","https://openalex.org/W1990218919","https://openalex.org/W1992761247","https://openalex.org/W1993572169","https://openalex.org/W1993900135","https://openalex.org/W1995308981","https://openalex.org/W1997463586","https://openalex.org/W1997606647","https://openalex.org/W1998934862","https://openalex.org/W2002220530","https://openalex.org/W2003627880","https://openalex.org/W2006352164","https://openalex.org/W2008123860","https://openalex.org/W2008388130","https://openalex.org/W2008869117","https://openalex.org/W2010365790","https://openalex.org/W2019501733","https://openalex.org/W2020584836","https://openalex.org/W2021284936","https://openalex.org/W2026010744","https://openalex.org/W2026082008","https://openalex.org/W2027020234","https://openalex.org/W2029500632","https://openalex.org/W2033304004","https://openalex.org/W2033334867","https://openalex.org/W2040441674","https://openalex.org/W2040728234","https://openalex.org/W2043293226","https://openalex.org/W2045558460","https://openalex.org/W2046668977","https://openalex.org/W2047276029","https://openalex.org/W2048247093","https://openalex.org/W2049796382","https://openalex.org/W2051315778","https://openalex.org/W2051459893","https://openalex.org/W2054200572","https://openalex.org/W2057459801","https://openalex.org/W2057787317","https://openalex.org/W2059021137","https://openalex.org/W2059082849","https://openalex.org/W2060706526","https://openalex.org/W2066144672","https://openalex.org/W2071770303","https://openalex.org/W2075316031","https://openalex.org/W2075962139","https://openalex.org/W2076316803","https://openalex.org/W2080131125","https://openalex.org/W2080714711","https://openalex.org/W2083876585","https://openalex.org/W2087117829","https://openalex.org/W2087946550","https://openalex.org/W2088745158","https://openalex.org/W2088783162","https://openalex.org/W2089394861","https://openalex.org/W2089964981","https://openalex.org/W2093567418","https://openalex.org/W2096428903","https://openalex.org/W2098677721","https://openalex.org/W2099027338","https://openalex.org/W2104643304","https://openalex.org/W2120095635","https://openalex.org/W2122694895","https://openalex.org/W2123396714","https://openalex.org/W2124357207","https://openalex.org/W2125496781","https://openalex.org/W2132122521","https://openalex.org/W2140549509","https://openalex.org/W2142221142","https://openalex.org/W2142732083","https://openalex.org/W2142826449","https://openalex.org/W2147540551","https://openalex.org/W2158557736","https://openalex.org/W2159606858","https://openalex.org/W2159874460","https://openalex.org/W2159875740","https://openalex.org/W2160228470","https://openalex.org/W2162494293","https://openalex.org/W2163408424","https://openalex.org/W2167345246","https://openalex.org/W2235923649","https://openalex.org/W2240581719","https://openalex.org/W2267868807","https://openalex.org/W2415981116","https://openalex.org/W4213003651","https://openalex.org/W4240874525","https://openalex.org/W4252486266","https://openalex.org/W4296404382","https://openalex.org/W6640101543"],"related_works":["https://openalex.org/W7099154146","https://openalex.org/W2040831173","https://openalex.org/W2039807689","https://openalex.org/W2160208179","https://openalex.org/W2078125340","https://openalex.org/W1980778878","https://openalex.org/W2023261291","https://openalex.org/W7042841596","https://openalex.org/W1983308210","https://openalex.org/W2041917861"],"abstract_inverted_index":{"Thousands":[0],"of":[1,17,49,86,131,138,203,233],"children":[2],"receive":[3],"methylphenidate":[4],"(MPH;":[5],"Ritalin)":[6],"for":[7,64,95,175],"attention":[8],"deficit/hyperactivity":[9],"disorder":[10],"(ADHD),":[11],"yet":[12],"the":[13,47,81,96,132,169,179,223],"long-term":[14],"neurochemical":[15],"consequences":[16],"MPH":[18,34,74,89,191,204,237],"treatment":[19,26],"are":[20],"unknown.":[21],"To":[22],"mimic":[23],"clinical":[24],"Ritalin":[25],"in":[27,53,69,73,123,151,158,168,178,211,215,249],"children,":[28],"male":[29],"rats":[30,87,118,164,185],"were":[31,61],"injected":[32],"with":[33,190,229,236],"(5":[35],"mg/kg)":[36],"or":[37,52],"vehicle":[38],"twice":[39],"daily":[40],"from":[41,58],"postnatal":[42],"day":[43],"7":[44],"(PND7)-PND35.":[45],"At":[46,79,161],"end":[48],"administration":[50],"(PND35)":[51],"adulthood":[54],"(PND135),":[55],"brain":[56,212,242],"sections":[57],"littermate":[59],"pairs":[60],"immunocytochemically":[62],"labeled":[63],"neurotransmitters":[65,210],"and":[66,106,126,150,172,220],"cytological":[67],"markers":[68],"16":[70],"regions":[71,213],"implicated":[72],"effects":[75,207,240],"and/or":[76],"ADHD":[77],"etiology.":[78],"PND35,":[80],"medial":[82,144],"prefrontal":[83],"cortex":[84],"(mPFC)":[85],"given":[88],"showed":[90,119,186],"55%":[91],"greater":[92],"immunoreactivity":[93],"(-ir)":[94],"catecholamine":[97],"marker":[98,134],"tyrosine":[99],"hydroxylase":[100],"(TH),":[101],"60%":[102],"more":[103],"Nissl-stained":[104],"cells,":[105],"40%":[107],"less":[108],"norepinephrine":[109],"transporter":[110],"(NET)-ir":[111],"density.":[112],"In":[113,143],"hippocampal":[114],"dentate":[115],"gyrus,":[116],"MPH-receiving":[117],"a":[120,127,173],"51%":[121],"decrease":[122],"NET-ir":[124],"density":[125],"61%":[128],"expanded":[129],"distribution":[130],"new-cell":[133],"PSA-NCAM":[135],"(polysialylated":[136],"form":[137],"neural":[139],"cell":[140],"adhesion":[141],"molecule).":[142],"striatum,":[145],"TH-ir":[146,177],"decreased":[147,166,176],"by":[148,156],"21%,":[149],"hypothalamus":[152],"neuropeptide":[153],"Y-ir":[154],"increased":[155],"10%":[157],"MPH-exposed":[159,163],"rats.":[160],"PND135,":[162],"exhibited":[165],"anxiety":[167],"elevated":[170],"plus-maze":[171],"trend":[174],"mPFC.":[180],"Neither":[181],"PND35":[182],"nor":[183],"PND135":[184],"major":[187],"structural":[188],"differences":[189],"exposure.":[192],"These":[193],"findings":[194],"suggest":[195],"that":[196,244],"developmental":[197],"exposure":[198],"to":[199],"high":[200],"therapeutic":[201],"doses":[202],"has":[205],"short-term":[206],"on":[208,241],"select":[209],"involved":[214],"motivated":[216],"behaviors,":[217],"cognition,":[218],"appetite,":[219],"stress.":[221],"Although":[222],"observed":[224],"neuroanatomical":[225],"changes":[226],"largely":[227],"resolve":[228],"time,":[230],"chronic":[231],"modulation":[232],"young":[234],"brains":[235],"may":[238],"exert":[239],"neurochemistry":[243],"modify":[245],"some":[246],"behaviors":[247],"even":[248],"adulthood.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}