{"id":"https://openalex.org/W2007355035","doi":"https://doi.org/10.1590/s0004-27302011000400005","title":"Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas","display_name":"Clomiphene fails to revert hypogonadism in most male patients with conventionally treated nonfunctioning pituitary adenomas","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W2007355035","doi":"https://doi.org/10.1590/s0004-27302011000400005","mag":"2007355035","pmid":"https://pubmed.ncbi.nlm.nih.gov/21779629"},"language":"en","primary_location":{"id":"doi:10.1590/s0004-27302011000400005","doi":"https://doi.org/10.1590/s0004-27302011000400005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302011000400005","pdf_url":"https://www.scielo.br/j/abem/a/LVD7BGNfBSgzYRh74fF7ztC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.scielo.br/j/abem/a/LVD7BGNfBSgzYRh74fF7ztC/?lang=en&format=pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006886470","display_name":"Rog\u00e9rio Silicani Ribeiro","orcid":"https://orcid.org/0000-0002-7957-7405","observed_orcids":["https://orcid.org/0000-0002-7957-7405"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rogerio Silicani Ribeiro","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055062683","display_name":"J\u00falio Abucham","orcid":"https://orcid.org/0000-0003-4804-1525","observed_orcids":["https://orcid.org/0000-0003-4804-1525"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Julio Abucham","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I88273585"],"apc_list":null,"apc_paid":null,"fwci":1.027,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75946819,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"55","issue":"4","first_page":"266","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clomiphene","display_name":"clomiphene citrate","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hypogonadism","display_name":"hypogonadism","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/testosterone","display_name":"testosterone","score":0.578000009059906},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9319999814033508},{"id":"https://openalex.org/keywords/erectile-function","display_name":"erectile function","score":0.781000018119812},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/prolactinoma","display_name":"prolactinoma","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dopaminergic-therapy","display_name":"dopaminergic therapy","score":0.7089999914169312},{"id":"https://openalex.org/keywords/male-hypogonadism","display_name":"male hypogonadism","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7471195459365845},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.731891393661499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6867763996124268},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.6765389442443848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6363328099250793},{"id":"https://openalex.org/C3020768380","wikidata":"https://www.wikidata.org/wiki/Q133993","display_name":"Erectile function","level":3,"score":0.5811600685119629},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4832092523574829},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.4738640785217285},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.46929293870925903},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.29657885432243347},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22938498854637146},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1570773720741272}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002996","descriptor_name":"Clomiphene","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004812","descriptor_name":"Epidemiologic Methods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007006","descriptor_name":"Hypogonadism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007172","descriptor_name":"Erectile Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010911","descriptor_name":"Pituitary Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1590/s0004-27302011000400005","doi":"https://doi.org/10.1590/s0004-27302011000400005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302011000400005","pdf_url":"https://www.scielo.br/j/abem/a/LVD7BGNfBSgzYRh74fF7ztC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},{"id":"pmid:21779629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21779629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos brasileiros de endocrinologia e metabologia","raw_type":"Clinical Trial"},{"id":"pmh:oai:americanae.aecid.es:2789613","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/6515","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da UNIFESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:scielo:S0004-27302011000400005","doi":null,"is_oa":true,"landing_page_url":"http://old.scielo.br/scielo.php?script=sci_arttext&amp;pid=S0004-27302011000400005","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.55 n.4 2011","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:2636568","doi":null,"is_oa":true,"landing_page_url":"http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp;amp; Metabologia v.55 n.4 2011","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.unifesp.br:11600/6515","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.unifesp.br/handle/11600/6515","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2292126130","doi":null,"is_oa":false,"landing_page_url":"http://www.aem-sbem.com/media/uploads/005_ABEM_554.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1590/s0004-27302011000400005","doi":"https://doi.org/10.1590/s0004-27302011000400005","is_oa":true,"landing_page_url":"https://doi.org/10.1590/s0004-27302011000400005","pdf_url":"https://www.scielo.br/j/abem/a/LVD7BGNfBSgzYRh74fF7ztC/?lang=en&format=pdf","source":{"id":"https://openalex.org/S15262226","display_name":"Arquivos Brasileiros de Endocrinologia & Metabologia","issn_l":"0004-2730","issn":["0004-2730","1677-9487"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310319680","host_organization_name":"Editora da Universidade de S\u00e3o Paulo","host_organization_lineage":["https://openalex.org/P4310319680"],"host_organization_lineage_names":["Editora da Universidade de S\u00e3o Paulo"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arquivos Brasileiros de Endocrinologia &amp; Metabologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007355035.pdf","grobid_xml":"https://content.openalex.org/works/W2007355035.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1518527904","https://openalex.org/W1592988911","https://openalex.org/W1976239781","https://openalex.org/W1979753676","https://openalex.org/W1995950792","https://openalex.org/W2006254421","https://openalex.org/W2011483789","https://openalex.org/W2011721848","https://openalex.org/W2029406824","https://openalex.org/W2060765936","https://openalex.org/W2068432964","https://openalex.org/W2070472127","https://openalex.org/W2091176826","https://openalex.org/W2092955774","https://openalex.org/W2096024465","https://openalex.org/W2098247759","https://openalex.org/W2115389486","https://openalex.org/W2120158027","https://openalex.org/W2136688633","https://openalex.org/W2169126323","https://openalex.org/W2170022091","https://openalex.org/W2324075496","https://openalex.org/W3036378166","https://openalex.org/W4211015768","https://openalex.org/W7073775216"],"related_works":["https://openalex.org/W2292126130","https://openalex.org/W2115389486","https://openalex.org/W4405221668","https://openalex.org/W4387361015","https://openalex.org/W4308142701","https://openalex.org/W4405220942","https://openalex.org/W4409912408","https://openalex.org/W2554587671","https://openalex.org/W2069575822","https://openalex.org/W2393766270"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,84],"effect":[4],"of":[5,67],"clomiphene":[6,68,72,114],"in":[7,79,101,122],"men":[8,28,108],"with":[9,36,106,109,125],"hypogonadism":[10],"and":[11,33,52,58,64,75,94],"conventionally":[12,126],"treated":[13,38,127],"nonfunctioning":[14],"pituitary":[15],"adenomas":[16],"(NFPA).":[17],"PATIENTS":[18],"AND":[19],"METHODS:":[20],"Open":[21],"label,":[22],"single-arm,":[23],"prospective":[24],"trial.":[25],"Nine":[26],"hypogonadal":[27,107],"(testosterone":[29],"<":[30],"300":[31],"ng/dL":[32],"low/normal":[34],"LH)":[35],"previously":[37],"NFPA.":[39,128],"Clomiphene":[40],"(50":[41],"mg/day":[42],"orally)":[43],"for":[44],"12":[45,65],"weeks.":[46],"Testosterone,":[47],"estradiol,":[48],"LH,":[49,92],"FSH,":[50,93],"prolactin":[51],"erectile":[53,76],"function":[54,77],"were":[55],"evaluated":[56],"before":[57],"after":[59],"10":[60],"days,":[61],"4,":[62],"8":[63],"weeks":[66],"treatment.":[69],"RESULTS:":[70],"After":[71],"treatment,":[73],"testosterone":[74,88,120],"improved":[78],"only":[80],"one":[81],"patient.":[82],"In":[83],"remaining":[85],"eight":[86],"patients,":[87],"levels":[89,121],"decreased":[90],"whereas":[91],"estradiol":[95],"remained":[96],"unchanged.":[97],"Insulin":[98],"sensitivity":[99],"increased":[100],"unresponsive":[102],"patients.":[103],"CONCLUSIONS:":[104],"Compared":[105],"prolactinomas":[110],"under":[111],"dopaminergic":[112],"therapy,":[113],"treatment":[115],"failed":[116],"to":[117],"restore":[118],"normal":[119],"most":[123],"patients":[124]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}