{"id":"https://openalex.org/W2007349694","doi":"https://doi.org/10.1016/j.cell.2011.01.033","title":"Revisiting the Central Dogma One Molecule at a Time","display_name":"Revisiting the Central Dogma One Molecule at a Time","publication_year":2011,"publication_date":"2011-02-01","ids":{"openalex":"https://openalex.org/W2007349694","doi":"https://doi.org/10.1016/j.cell.2011.01.033","mag":"2007349694","pmid":"https://pubmed.ncbi.nlm.nih.gov/21335233","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063003"},"language":"en","primary_location":{"id":"doi:10.1016/j.cell.2011.01.033","doi":"https://doi.org/10.1016/j.cell.2011.01.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2011.01.033","pdf_url":"http://www.cell.com/article/S0092867411001073/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S0092867411001073/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010743284","display_name":"Carlos Bustamante","orcid":"https://orcid.org/0000-0002-2970-0073","observed_orcids":["https://orcid.org/0000-0002-2970-0073"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Carlos Bustamante","raw_affiliation_strings":["Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, 94720, USA. carlos@alice.berkeley.edu","Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA","Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, CA 94720, USA","Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA","Physics Department, University of California, Berkeley, CA 94720, USA","QB3 Institute, University of California, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, 94720, USA. carlos@alice.berkeley.edu","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I95457486"]},{"raw_affiliation_string":"Jason L. Choy Laboratory of Single-Molecule Biophysics, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"Physics Department, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"QB3 Institute, University of California, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069751678","display_name":"Wei Cheng","orcid":"https://orcid.org/0000-0003-0332-1566","observed_orcids":["https://orcid.org/0000-0003-0332-1566"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Cheng","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064272775","display_name":"Yara X. Mejia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yara X. Mejia","raw_affiliation_strings":["Biological Micro and Nanotechnology, Max Planck Institute for Biophysical Chemistry, Am Fa\u00dfberg 11, D-37077 G\u00f6ttingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Micro and Nanotechnology, Max Planck Institute for Biophysical Chemistry, Am Fa\u00dfberg 11, D-37077 G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210131661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010743284"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I148283060","https://openalex.org/I95457486"],"apc_list":{"value":11400,"currency":"USD","value_usd":11400},"apc_paid":null,"fwci":1.1509,"has_fulltext":false,"cited_by_count":182,"citation_normalized_percentile":{"value":0.7768595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"144","issue":"4","first_page":"480","last_page":"497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.4578000009059906,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.4578000009059906,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.2012999951839447,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-dogma","display_name":"central dogma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/single-molecule-fluorescence","display_name":"single-molecule fluorescence","score":0.7210000157356262},{"id":"https://openalex.org/keywords/molecular-machines","display_name":"molecular machines","score":0.6380000114440918},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.6269999742507935},{"id":"https://openalex.org/keywords/transcription","display_name":"transcription","score":0.7649999856948853},{"id":"https://openalex.org/keywords/rna-processing","display_name":"RNA processing","score":0.5910000205039978},{"id":"https://openalex.org/keywords/thermodynamic-efficiency","display_name":"thermodynamic efficiency","score":0.7839999794960022},{"id":"https://openalex.org/keywords/transient-intermediates","display_name":"transient intermediates","score":0.828000009059906},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"molecular dynamics","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9130546450614929},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3881830871105194},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3812333047389984}],"mesh":[{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019065","descriptor_name":"Virus Assembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.cell.2011.01.033","doi":"https://doi.org/10.1016/j.cell.2011.01.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2011.01.033","pdf_url":"http://www.cell.com/article/S0092867411001073/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},{"id":"pmid:21335233","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21335233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2304541","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063003","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3063003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3063003","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell","raw_type":"Text"},{"id":"pmh:oai:edoc.mpg.de:546498","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/546498","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell, v.144, 480-497 (2011)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.cell.2011.01.033","doi":"https://doi.org/10.1016/j.cell.2011.01.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cell.2011.01.033","pdf_url":"http://www.cell.com/article/S0092867411001073/pdf","source":{"id":"https://openalex.org/S110447773","display_name":"Cell","issn_l":"0092-8674","issn":["0092-8674","1097-4172"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007349694.pdf"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W570672306","https://openalex.org/W1487659884","https://openalex.org/W1493170168","https://openalex.org/W1503666504","https://openalex.org/W1517376495","https://openalex.org/W1523619671","https://openalex.org/W1531152013","https://openalex.org/W1533712488","https://openalex.org/W1541514857","https://openalex.org/W1557627802","https://openalex.org/W1569060300","https://openalex.org/W1619891693","https://openalex.org/W1759053000","https://openalex.org/W1864762190","https://openalex.org/W1921369870","https://openalex.org/W1964767569","https://openalex.org/W1966204777","https://openalex.org/W1968280183","https://openalex.org/W1969868512","https://openalex.org/W1970611074","https://openalex.org/W1972003375","https://openalex.org/W1972061284","https://openalex.org/W1972069400","https://openalex.org/W1973274146","https://openalex.org/W1973721031","https://openalex.org/W1974734522","https://openalex.org/W1975729486","https://openalex.org/W1979275259","https://openalex.org/W1979645700","https://openalex.org/W1982433583","https://openalex.org/W1986381105","https://openalex.org/W1986663423","https://openalex.org/W1989073024","https://openalex.org/W1991971909","https://openalex.org/W1992564866","https://openalex.org/W1993374643","https://openalex.org/W1998276013","https://openalex.org/W2000410597","https://openalex.org/W2000752771","https://openalex.org/W2001907809","https://openalex.org/W2003875234","https://openalex.org/W2005307528","https://openalex.org/W2008424177","https://openalex.org/W2008739199","https://openalex.org/W2011989198","https://openalex.org/W2015404233","https://openalex.org/W2020010253","https://openalex.org/W2021199098","https://openalex.org/W2021707474","https://openalex.org/W2021984369","https://openalex.org/W2022737233","https://openalex.org/W2023346112","https://openalex.org/W2024858227","https://openalex.org/W2025111140","https://openalex.org/W2025807248","https://openalex.org/W2026733658","https://openalex.org/W2028904598","https://openalex.org/W2031580496","https://openalex.org/W2032297944","https://openalex.org/W2033087969","https://openalex.org/W2033245706","https://openalex.org/W2033428498","https://openalex.org/W2036371955","https://openalex.org/W2036475903","https://openalex.org/W2041008570","https://openalex.org/W2041177404","https://openalex.org/W2041604608","https://openalex.org/W2042528449","https://openalex.org/W2043249713","https://openalex.org/W2046298637","https://openalex.org/W2049757176","https://openalex.org/W2051502948","https://openalex.org/W2051959261","https://openalex.org/W2054455698","https://openalex.org/W2056431229","https://openalex.org/W2058048622","https://openalex.org/W2059158601","https://openalex.org/W2059315855","https://openalex.org/W2064920037","https://openalex.org/W2066521860","https://openalex.org/W2068761039","https://openalex.org/W2069281865","https://openalex.org/W2069757035","https://openalex.org/W2070394525","https://openalex.org/W2071246239","https://openalex.org/W2071804506","https://openalex.org/W2072690167","https://openalex.org/W2074636264","https://openalex.org/W2075970359","https://openalex.org/W2076034830","https://openalex.org/W2076710572","https://openalex.org/W2080720176","https://openalex.org/W2081342248","https://openalex.org/W2081407528","https://openalex.org/W2083630006","https://openalex.org/W2084744901","https://openalex.org/W2088293709","https://openalex.org/W2088721967","https://openalex.org/W2090845358","https://openalex.org/W2091007136","https://openalex.org/W2091636398","https://openalex.org/W2093707543","https://openalex.org/W2101202966","https://openalex.org/W2104728958","https://openalex.org/W2105571876","https://openalex.org/W2108624464","https://openalex.org/W2109024607","https://openalex.org/W2110725132","https://openalex.org/W2110788152","https://openalex.org/W2111736586","https://openalex.org/W2115942985","https://openalex.org/W2118006330","https://openalex.org/W2121431496","https://openalex.org/W2122719011","https://openalex.org/W2124081058","https://openalex.org/W2125053230","https://openalex.org/W2126023294","https://openalex.org/W2127380975","https://openalex.org/W2131171155","https://openalex.org/W2131345241","https://openalex.org/W2133500066","https://openalex.org/W2133788397","https://openalex.org/W2134082301","https://openalex.org/W2134682782","https://openalex.org/W2135015314","https://openalex.org/W2136921063","https://openalex.org/W2139624902","https://openalex.org/W2141200498","https://openalex.org/W2142706774","https://openalex.org/W2146173293","https://openalex.org/W2146925966","https://openalex.org/W2147683139","https://openalex.org/W2148007373","https://openalex.org/W2151476504","https://openalex.org/W2152363123","https://openalex.org/W2154975876","https://openalex.org/W2155581697","https://openalex.org/W2156300176","https://openalex.org/W2158661016","https://openalex.org/W2160213949","https://openalex.org/W2160471420","https://openalex.org/W2161505765","https://openalex.org/W2166053360","https://openalex.org/W2166288313","https://openalex.org/W2167092674","https://openalex.org/W2167150894","https://openalex.org/W2168419371","https://openalex.org/W2169659701","https://openalex.org/W2169791141","https://openalex.org/W2335520030","https://openalex.org/W4299941012","https://openalex.org/W6837773059"],"related_works":["https://openalex.org/W2070424720","https://openalex.org/W7095410561","https://openalex.org/W2022985580","https://openalex.org/W1983347890","https://openalex.org/W2080339774","https://openalex.org/W1998910860","https://openalex.org/W3193315165","https://openalex.org/W110536380","https://openalex.org/W2591244236","https://openalex.org/W2061176310"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}