{"id":"https://openalex.org/W2007335513","doi":"https://doi.org/10.1001/archinte.128.3.411","title":"Vitamin E and Porphyrin Metabolism in Man","display_name":"Vitamin E and Porphyrin Metabolism in Man","publication_year":1971,"publication_date":"1971-09-01","ids":{"openalex":"https://openalex.org/W2007335513","doi":"https://doi.org/10.1001/archinte.128.3.411","mag":"2007335513","pmid":"https://pubmed.ncbi.nlm.nih.gov/5093212"},"language":"en","primary_location":{"id":"doi:10.1001/archinte.128.3.411","doi":"https://doi.org/10.1001/archinte.128.3.411","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.128.3.411","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045586731","display_name":"Padmanabhan P. Nair","orcid":"https://orcid.org/0000-0002-8925-1193","observed_orcids":["https://orcid.org/0000-0002-8925-1193"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"P. P. Nair","raw_affiliation_strings":["Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045586731"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":null,"apc_paid":null,"fwci":1.1744,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.75272298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"128","issue":"3","first_page":"411","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.9919999837875366},{"id":"https://openalex.org/keywords/porphyria","display_name":"porphyria","score":0.9879999756813049},{"id":"https://openalex.org/keywords/porphyrin-metabolism","display_name":"porphyrin metabolism","score":0.9900000095367432},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9169999957084656},{"id":"https://openalex.org/keywords/porphobilinogen","display_name":"porphobilinogen","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coproporphyrin","display_name":"coproporphyrin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/uroporphyrin","display_name":"uroporphyrin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/coproporphyrinuria","display_name":"coproporphyrinuria","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.7379999756813049},{"id":"https://openalex.org/keywords/chronic-alcoholism","display_name":"chronic alcoholism","score":0.6729999780654907},{"id":"https://openalex.org/keywords/urinary-porphyrin-excretion","display_name":"urinary porphyrin excretion","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2776682811","wikidata":"https://www.wikidata.org/wiki/Q421178","display_name":"Porphobilinogen","level":3,"score":0.8993761539459229},{"id":"https://openalex.org/C2777940757","wikidata":"https://www.wikidata.org/wiki/Q271759","display_name":"Porphyria","level":2,"score":0.6854890584945679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.679004967212677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6065553426742554},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.6029249429702759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5414903163909912},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5246807932853699},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.4845768213272095},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4486881196498871},{"id":"https://openalex.org/C2779480358","wikidata":"https://www.wikidata.org/wiki/Q422926","display_name":"Porphyrin","level":2,"score":0.4344837963581085},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.42129674553871155},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29013770818710327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16443940997123718}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007982","descriptor_name":"Levulinic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011164","descriptor_name":"Porphyrias","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011164","descriptor_name":"Porphyrias","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011166","descriptor_name":"Porphyrins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1001/archinte.128.3.411","doi":"https://doi.org/10.1001/archinte.128.3.411","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.128.3.411","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"doi:10.1001/archinte.1971.00310210087008","doi":"https://doi.org/10.1001/archinte.1971.00310210087008","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archinte.1971.00310210087008","pdf_url":null,"source":{"id":"https://openalex.org/S4210206803","display_name":"Archives of Internal Medicine","issn_l":"0003-9926","issn":["0003-9926","0730-188X","1538-3679"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:5093212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5093212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of internal medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W174059356","https://openalex.org/W940577904","https://openalex.org/W1482280407","https://openalex.org/W1604536885","https://openalex.org/W1811061766","https://openalex.org/W1974061246","https://openalex.org/W1976413962","https://openalex.org/W2039627345","https://openalex.org/W2045392291","https://openalex.org/W2051196895","https://openalex.org/W2055771598","https://openalex.org/W2056015765","https://openalex.org/W2056480465","https://openalex.org/W2062160987","https://openalex.org/W2083810940","https://openalex.org/W2093315792","https://openalex.org/W2120812900","https://openalex.org/W2337209710","https://openalex.org/W2412799186","https://openalex.org/W2444443181","https://openalex.org/W2467478080","https://openalex.org/W2472027291","https://openalex.org/W2617351802"],"related_works":["https://openalex.org/W1978148010","https://openalex.org/W4237893474","https://openalex.org/W7214220993","https://openalex.org/W2090826680","https://openalex.org/W1969414667","https://openalex.org/W2050973781","https://openalex.org/W2048531832","https://openalex.org/W2042044157","https://openalex.org/W1985069507","https://openalex.org/W1975568122"],"abstract_inverted_index":{"Four":[0],"patients":[1,77],"with":[2,8,52,88],"symptoms":[3],"of":[4,19,61,72,81,104,116,119],"porphyria":[5,108],"were":[6,27,45,67],"treated":[7],"water":[9],"soluble":[10],"vitamin":[11,38,54,62,96,105],"E.":[12,97],"In":[13],"all":[14],"four":[15],"patients,":[16],"urinary":[17],"excretion":[18],"\u03b4-aminolevulinic":[20],"acid,":[21],"porphobilinogen,":[22],"coproporphyrins,":[23],"and":[24,55],"uroporphyrins,":[25],"which":[26,44],"initially":[28],"elevated,":[29],"decreased":[30],"to":[31,50,92,95],"normal":[32,48],"levels":[33,40],"following":[34],"therapy.":[35],"The":[36,59,85],"initial":[37],"E":[39,63,106],"in":[41,69,107],"whole":[42],"blood":[43],"lower":[46],"than":[47],"responded":[49],"treatment":[51],"the":[53,102,117],"paralleled":[56],"clinical":[57,79],"improvement.":[58],"effects":[60,118],"on":[64],"porphyrin":[65],"metabolism":[66],"examined":[68],"a":[70,114],"group":[71],"six":[73],"male":[74],"chronic":[75,82],"alcoholic":[76],"without":[78],"evidence":[80],"liver":[83],"disease.":[84],"coproporphyrinuria":[86],"associated":[87],"alcoholism":[89],"was":[90],"found":[91],"be":[93],"nonresponsive":[94],"Our":[98],"observations":[99],"indicate":[100],"that":[101],"action":[103],"is":[109],"probably":[110],"not":[111],"mediated":[112],"through":[113],"reversal":[115],"any":[120],"concurrent":[121],"alcoholism.":[122]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
