{"id":"https://openalex.org/W2007333999","doi":"https://doi.org/10.1097/00007691-199508000-00011","title":"Binding of 17-\u03b1-Methyltestosterone In Vitro to Human Sex Hormone Binding Globulin and Rat Ventral Prostate Androgen Receptors","display_name":"Binding of 17-\u03b1-Methyltestosterone In Vitro to Human Sex Hormone Binding Globulin and Rat Ventral Prostate Androgen Receptors","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2007333999","doi":"https://doi.org/10.1097/00007691-199508000-00011","mag":"2007333999","pmid":"https://pubmed.ncbi.nlm.nih.gov/7482693"},"language":"en","primary_location":{"id":"doi:10.1097/00007691-199508000-00011","doi":"https://doi.org/10.1097/00007691-199508000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199508000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062962860","display_name":"Brinda Wiita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098579","display_name":"Solvay (United States)","ror":"https://ror.org/016k8tv59","country_code":"US","type":"company","lineage":["https://openalex.org/I17170469","https://openalex.org/I4210098579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brinda Wiita","raw_affiliation_strings":["Solvay Pharmaceuticals, Inc., Marietta, Georgia 30062, USA","Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Solvay Pharmaceuticals, Inc., Marietta, Georgia 30062, USA","institution_ids":["https://openalex.org/I4210098579"]},{"raw_affiliation_string":"Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065046215","display_name":"Althea Artis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Althea Artis","raw_affiliation_strings":["and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","institution_ids":[]},{"raw_affiliation_string":"Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003068962","display_name":"Dennis M. Ackerman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis M. Ackerman","raw_affiliation_strings":["and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","institution_ids":[]},{"raw_affiliation_string":"Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083421561","display_name":"Christopher Longcope","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Longcope","raw_affiliation_strings":["and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and reprint requests to Dr. B. Wiita at Solvay Pharmaceuticals, Inc., 901 Sawyer Road, Marietta, GA 30062 U.S.A","institution_ids":[]},{"raw_affiliation_string":"Solvay Pharmaceuticals, Inc., Marietta, Georgia, and *The University of Massachusetts, Worcester, Massachusetts, U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062962860"],"corresponding_institution_ids":["https://openalex.org/I4210098579"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.1164749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"17","issue":"4","first_page":"377","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.12780000269412994,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methyltestosterone","display_name":"methyltestosterone","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.925000011920929},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ventral-prostate","display_name":"ventral prostate","score":0.8899999856948853},{"id":"https://openalex.org/keywords/relative-binding-affinity","display_name":"relative binding affinity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/dihydrotestosterone","display_name":"dihydrotestosterone","score":0.9760000109672546},{"id":"https://openalex.org/keywords/androgen-binding","display_name":"androgen binding","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2778586440","wikidata":"https://www.wikidata.org/wiki/Q421768","display_name":"Methyltestosterone","level":2,"score":0.8144705295562744},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.761891782283783},{"id":"https://openalex.org/C30092816","wikidata":"https://www.wikidata.org/wiki/Q419613","display_name":"Sex hormone-binding globulin","level":4,"score":0.7617886066436768},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.6969953775405884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6955959796905518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6715912818908691},{"id":"https://openalex.org/C2779881493","wikidata":"https://www.wikidata.org/wiki/Q411054","display_name":"Dihydrotestosterone","level":4,"score":0.6226072311401367},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4400627017021179},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40938496589660645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39909398555755615},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3938741981983185},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.2293468713760376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1669084131717682},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008777","descriptor_name":"Methyltestosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012738","descriptor_name":"Sex Hormone-Binding Globulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013196","descriptor_name":"Dihydrotestosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007691-199508000-00011","doi":"https://doi.org/10.1097/00007691-199508000-00011","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199508000-00011","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:7482693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7482693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2019269074","https://openalex.org/W2474687666","https://openalex.org/W2026568709","https://openalex.org/W1979746891","https://openalex.org/W2009548497","https://openalex.org/W2028769287","https://openalex.org/W2013068652","https://openalex.org/W1964606223","https://openalex.org/W2035218537","https://openalex.org/W2091988672"],"abstract_inverted_index":{"We":[0],"measured":[1],"the":[2,11,33,48,71,82],"relative":[3],"binding":[4],"affinity":[5],"(RBA)":[6],"of":[7,35,43,66,85],"17-alpha-methyltestosterone":[8],"(MET)":[9],"for":[10,47,53],"rat":[12],"prostate":[13],"androgen":[14,49,56,68],"receptor":[15],"and":[16],"human":[17],"sex":[18],"hormone-binding":[19],"globulin":[20],"(SHBG)":[21],"in":[22,27,78],"vitro.":[23],"The":[24,41,55,76],"reference":[25],"compound":[26],"both":[28],"instances":[29],"was":[30,37,45],"dihydrotestosterone":[31],"(DHT),":[32],"RBA":[34,42],"which":[36],"set":[38],"at":[39],"100%.":[40],"methyltestosterone":[44],"44%":[46],"receptor,":[50,57],"but":[51],"11%":[52],"SHBG.":[54,75],"therefore,":[58],"would":[59],"appear":[60],"to":[61,70],"recognize":[62],"a":[63],"different":[64],"part":[65],"an":[67],"compared":[69],"recognition":[72],"site":[73],"on":[74],"difference":[77],"RBAs":[79],"may":[80],"amplify":[81],"biologic":[83],"action":[84],"methyltestosterone.":[86]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
