{"id":"https://openalex.org/W2007302736","doi":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","title":"Abstract PL01-02: Early life environmental exposures, sentinel reproductive events and cancer risk in women","display_name":"Abstract PL01-02: Early life environmental exposures, sentinel reproductive events and cancer risk in women","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2007302736","doi":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","mag":"2007302736"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.prev-12-pl01-02","doi":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013262825","display_name":"Michele R. Forman","orcid":"https://orcid.org/0000-0002-3060-6068","observed_orcids":["https://orcid.org/0000-0002-3060-6068"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michele Robin Forman","raw_affiliation_strings":["University of Texas at Austin, Austin, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin, Austin, TX","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013262825"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"11_Supplement","first_page":"PL01","last_page":"02"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.6240000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.25369998812675476,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.9919999837875366},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.9869999885559082},{"id":"https://openalex.org/keywords/early-life-exposure","display_name":"early life exposure","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hormone-exposure","display_name":"hormone exposure","score":0.6850000023841858},{"id":"https://openalex.org/keywords/reproductive-aging","display_name":"reproductive aging","score":0.492000013589859},{"id":"https://openalex.org/keywords/socioeconomic-status","display_name":"socioeconomic status","score":0.5680000185966492},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.7200000286102295},{"id":"https://openalex.org/keywords/longitudinal-cohort","display_name":"longitudinal cohort","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C4258228","wikidata":"https://www.wikidata.org/wiki/Q492514","display_name":"Menarche","level":2,"score":0.841568112373352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6586911082267761},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.6279418468475342},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4617682993412018},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.4184163212776184},{"id":"https://openalex.org/C147077947","wikidata":"https://www.wikidata.org/wiki/Q1515895","display_name":"Socioeconomic status","level":3,"score":0.41575708985328674},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.4014872908592224},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.27584847807884216},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.27176231145858765},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2584570348262787},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15198194980621338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1305694580078125},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1940-6207.prev-12-pl01-02","doi":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1940-6207.prev-12-pl01-02","pdf_url":null,"source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5099999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4299672468","https://openalex.org/W3150077228","https://openalex.org/W2796841829","https://openalex.org/W2118430169","https://openalex.org/W2052968983","https://openalex.org/W1964367875","https://openalex.org/W1990631725","https://openalex.org/W4415451456","https://openalex.org/W64866589","https://openalex.org/W2766804638"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"woman's":[2,29],"age":[3,8,79,179],"at":[4,9,80,98,180],"menarche":[5,81,99,181],"and":[6,14,42,46,70,82,90,100,103,133,153,160,172,182,203,208,222,227,245],"her":[7,17,33],"menopause":[10,83,101,226],"are":[11,37,52,211],"the":[12,73,120,123,140,147,157,164,215,228,254],"alpha":[13],"omega":[15],"of":[16,22,39,49,68,198,217,253],"reproductive":[18,243],"years.":[19],"The":[20],"timing":[21,48],"these":[23],"milestones":[24],"is":[25],"critical":[26],"for":[27,56,62,75,86,92],"a":[28,76,129],"health":[30],"trajectory":[31],"over":[32],"lifespan,":[34],"as":[35],"they":[36],"indicators":[38],"ovarian":[40,173],"function":[41],"aging.":[43],"Both":[44],"early":[45],"late":[47],"either":[50],"event":[51],"associated":[53],"with":[54],"risk":[55,61,247],"adverse":[57],"health,":[58],"in":[59,65,96,104,112,231,248,262],"particular":[60],"hormonal":[63,154,202],"cancers":[64],"women,":[66],"quality":[67],"life":[69,148,239],"lifespan.":[71],"Thus,":[72],"search":[74],"relationship":[77],"between":[78,122],"has":[84],"consequences":[85],"chronic":[87],"disease":[88],"prevention":[89],"implications":[91],"public":[93],"health.":[94],"Trends":[95],"ages":[97],"worldwide":[102],"sub-populations":[105],"will":[106,187],"be":[107],"presented,":[108],"however":[109],"challenges":[110],"exist":[111],"constructing":[113],"trends.":[114],"Among":[115],"36":[116],"studies":[117,197],"that":[118,175,210],"examine":[119],"association":[121],"two":[124,134],"sentinel":[125,242],"events,":[126,244],"10":[127],"reported":[128,135],"significant":[130],"direct":[131],"association,":[132,138],"an":[136],"inverse":[137],"while":[139],"remaining":[141],"26":[142],"had":[143],"null":[144],"results.":[145],"Over":[146],"course,":[149],"exposures":[150],"to":[151,166,213],"environmental":[152,204,240],"factors":[155,200],"during":[156],"prenatal,":[158],"postnatal":[159],"adolescent":[161],"periods":[162],"have":[163],"potential":[165],"initiate,":[167],"promote,":[168],"and/or":[169],"alter":[170],"mammary":[171],"changes":[174],"may":[176],"affect":[177],"both":[178],"natural":[183],"menopause.":[184],"This":[185],"presentation":[186],"focus":[188],"on":[189,260],"epidemiological":[190],"research":[191],"from":[192],"several":[193],"longitudinal":[194],"prospective":[195],"cohort":[196],"multiple":[199],"including":[201,219],"exposures,":[205,241],"socioeconomic":[206],"status":[207],"stress":[209],"hypothesized":[212],"influence":[214],"tempo":[216],"growth":[218],"body":[220],"size":[221],"height,":[223],"development,":[224],"menarche,":[225],"aging":[229],"process":[230],"women.":[232,249],"Citation":[233],"Format:":[234],"Michele":[235],"Robin":[236],"Forman.":[237],"Early":[238],"cancer":[246],"[abstract].":[250],"In:":[251],"Proceedings":[252],"Eleventh":[255],"Annual":[256],"AACR":[257],"International":[258],"Conference":[259],"Frontiers":[261],"Cancer":[263,274],"Prevention":[264],"Research;":[265],"2012":[266],"Oct":[267],"16-19;":[268],"Anaheim,":[269],"CA.":[270],"Philadelphia":[271],"(PA):":[272],"AACR;":[273],"Prev":[275],"Res":[276],"2012;5(11":[277],"Suppl):Abstract":[278],"nr":[279],"PL01-02.":[280]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2016-06-24T00:00:00"}