{"id":"https://openalex.org/W2007289008","doi":"https://doi.org/10.1155/2012/104317","title":"Sertraline May Improve Language Developmental Trajectory in Young Children with Fragile X Syndrome: A Retrospective Chart Review","display_name":"Sertraline May Improve Language Developmental Trajectory in Young Children with Fragile X Syndrome: A Retrospective Chart Review","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2007289008","doi":"https://doi.org/10.1155/2012/104317","mag":"2007289008","pmid":"https://pubmed.ncbi.nlm.nih.gov/22934167","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3420618"},"language":"en","primary_location":{"id":"doi:10.1155/2012/104317","doi":"https://doi.org/10.1155/2012/104317","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/104317","pdf_url":"https://downloads.hindawi.com/journals/aurt/2012/104317.pdf","source":{"id":"https://openalex.org/S9405235","display_name":"Autism Research and Treatment","issn_l":"2090-1925","issn":["2090-1925","2090-1933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism Research and Treatment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/aurt/2012/104317.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069473771","display_name":"Tri Indah Winarni","orcid":"https://orcid.org/0000-0001-5450-2813","observed_orcids":["https://orcid.org/0000-0001-5450-2813"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["ID","US"],"is_corresponding":false,"raw_author_name":"Tri Indah Winarni","raw_affiliation_strings":["Division of Human Genetic, Center for Biomedical Research, Faculty of Medicine, Diponegoro University, Central Java Semarang 50231, Indonesia","Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":"https://orcid.org/0000-0001-5450-2813","affiliations":[{"raw_affiliation_string":"Division of Human Genetic, Center for Biomedical Research, Faculty of Medicine, Diponegoro University, Central Java Semarang 50231, Indonesia","institution_ids":["https://openalex.org/I11855966"]},{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061257120","display_name":"Weerasak Chonchaiya","orcid":"https://orcid.org/0000-0002-0223-9969","observed_orcids":["https://orcid.org/0000-0002-0223-9969"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]},{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["TH","US"],"is_corresponding":false,"raw_author_name":"Weerasak Chonchaiya","raw_affiliation_strings":["Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand","Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]},{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Evan Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Adams","raw_affiliation_strings":["Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jacky Au","orcid":"https://orcid.org/0000-0001-9836-9292","observed_orcids":["https://orcid.org/0000-0001-9836-9292"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacky Au","raw_affiliation_strings":["Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":"https://orcid.org/0000-0001-9836-9292","affiliations":[{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031334961","display_name":"Yi Mu","orcid":"https://orcid.org/0000-0001-5660-440X","observed_orcids":["https://orcid.org/0000-0001-5660-440X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Mu","raw_affiliation_strings":["Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Department of Public Health Sciences, University of California, Davis, CA 95817, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026968101","display_name":"Susan Michelle Rivera","orcid":"https://orcid.org/0000-0002-4870-4774","observed_orcids":["https://orcid.org/0000-0002-4870-4774"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Rivera","raw_affiliation_strings":["Center for Mind and Brain, University of California, Davis, CA 95817, USA","Department of Psychology, University of California, Davis, CA 95817, USA","Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Mind and Brain, University of California, Davis, CA 95817, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Psychology, University of California, Davis, CA 95817, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055319271","display_name":"Danh V. Nguyen","orcid":"https://orcid.org/0000-0002-4025-8239","observed_orcids":["https://orcid.org/0000-0002-4025-8239"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danh V. Nguyen","raw_affiliation_strings":["Department of Psychology, University of California, Davis, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of California, Davis, CA 95817, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086196058","display_name":"Randi Jenssen Hagerman","orcid":"https://orcid.org/0000-0001-5029-8448","observed_orcids":["https://orcid.org/0000-0001-5029-8448","https://orcid.org/0000-0002-8026-6559"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Randi J. Hagerman","raw_affiliation_strings":["Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Pediatrics, University of California-Davis Medical Center, Sacramento, CA 95817, USA","institution_ids":["https://openalex.org/I4210160527"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086196058"],"corresponding_institution_ids":["https://openalex.org/I4210160527"],"apc_list":{"value":800,"currency":"USD","value_usd":800},"apc_paid":{"value":800,"currency":"USD","value_usd":800},"fwci":3.765,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93987706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13258","display_name":"Williams Syndrome Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.8960000276565552},{"id":"https://openalex.org/keywords/fragile-x-syndrome","display_name":"fragile X syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/language-development","display_name":"language development","score":0.9480000138282776},{"id":"https://openalex.org/keywords/expressive-language","display_name":"expressive language","score":0.6000000238418579},{"id":"https://openalex.org/keywords/receptive-language","display_name":"receptive language","score":1.0},{"id":"https://openalex.org/keywords/young-children","display_name":"young children","score":0.6050000190734863},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.49900001287460327},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.7960000038146973},{"id":"https://openalex.org/keywords/mullen-scales-of-early-learning","display_name":"Mullen Scales of Early Learning","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.8491138815879822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.716089129447937},{"id":"https://openalex.org/C190812933","wikidata":"https://www.wikidata.org/wiki/Q28923","display_name":"Chart","level":2,"score":0.6686664819717407},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4601297080516815},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4270375967025757},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.24333763122558594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17964312434196472},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.0632791519165039},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":11,"locations":[{"id":"doi:10.1155/2012/104317","doi":"https://doi.org/10.1155/2012/104317","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/104317","pdf_url":"https://downloads.hindawi.com/journals/aurt/2012/104317.pdf","source":{"id":"https://openalex.org/S9405235","display_name":"Autism Research and Treatment","issn_l":"2090-1925","issn":["2090-1925","2090-1933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism Research and Treatment","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2429176","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3420618","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3420618","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3420618","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism Res Treat","raw_type":"Text"},{"id":"pmid:22934167","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22934167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism research and treatment","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8953t66p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8953t66p","pdf_url":"https://escholarship.org/content/qt8953t66p/qt8953t66p.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autism Research and Treatment, vol 2012, iss 1","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.802.1684","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.802.1684","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/97/85/AURT2012-104317.PMC3420618.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:302e9509c48243aa802fb3931737d0f1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/302e9509c48243aa802fb3931737d0f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autism Research and Treatment, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt8953t66p","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8953t66p","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Autism research and treatment, vol 2012","raw_type":"article"},{"id":"pmh:qt8953t66p","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/8953t66p","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indah Winarni, T; Chonchaiya, W; Adams, E; Au, J; Mu, Y; Rivera, SM; \u00c2\u00a0et al.(2012). Sertraline may improve language developmental trajectory in young children with fragile x syndrome: a retrospective chart review.. Autism research and treatment, 2012, 104317. doi: 10.1155/2012/104317. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8953t66p","raw_type":"article"},{"id":"doi:10.60692/c4x6q-prz04","doi":"https://doi.org/10.60692/c4x6q-prz04","is_oa":true,"landing_page_url":"https://doi.org/10.60692/c4x6q-prz04","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/xncdd-41h79","doi":"https://doi.org/10.60692/xncdd-41h79","is_oa":true,"landing_page_url":"https://doi.org/10.60692/xncdd-41h79","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1155/2012/104317","doi":"https://doi.org/10.1155/2012/104317","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/104317","pdf_url":"https://downloads.hindawi.com/journals/aurt/2012/104317.pdf","source":{"id":"https://openalex.org/S9405235","display_name":"Autism Research and Treatment","issn_l":"2090-1925","issn":["2090-1925","2090-1933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Autism Research and Treatment","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1184855618","display_name":null,"funder_award_id":"RR-024146","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1898880685","display_name":null,"funder_award_id":"AG032119","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2163302634","display_name":null,"funder_award_id":"AG032115","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2183559457","display_name":null,"funder_award_id":"HD036071","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G2335821925","display_name":null,"funder_award_id":"HD02274","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2738306040","display_name":null,"funder_award_id":"AG032115","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2757890966","display_name":"Development of targeted therapeutic agents for the treatment of FXTAS (2 of 6)","funder_award_id":"RL1AG032119","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3428699070","display_name":"Characterization and Treatment of CNS Abnormalities in Premutation Carriers (4 of","funder_award_id":"RL1AG032115","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3482729776","display_name":"Neuro Therapeutics Research Institute (1 of 6)","funder_award_id":"UL1DE019583","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3566507055","display_name":null,"funder_award_id":"R40MC22641","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G360721996","display_name":null,"funder_award_id":"AG032119","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3746498070","display_name":null,"funder_award_id":"HD036071","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3777162036","display_name":null,"funder_award_id":"MH078041","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3876448596","display_name":null,"funder_award_id":"MH078041","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3890775050","display_name":null,"funder_award_id":"AG032115","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G3929748281","display_name":null,"funder_award_id":"90DD05969","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4037113195","display_name":null,"funder_award_id":"R40MC22641","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G4142340636","display_name":"UC Davis Clinical and Translational Science Center","funder_award_id":"UL1RR024146","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G44094036","display_name":null,"funder_award_id":"AG032119","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G4637982368","display_name":null,"funder_award_id":"UL1 RR024146","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G5091678919","display_name":null,"funder_award_id":"DE019583","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5178656058","display_name":null,"funder_award_id":"R40MC22641","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5356587411","display_name":"Research in Intellectual and Developmental Disabilities","funder_award_id":"P30HD002274","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5878270729","display_name":"Interdisciplinary Training Program in Neurotherapeutics (6 of 6)","funder_award_id":"TL1DA024854","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G6107062629","display_name":null,"funder_award_id":"MH078041","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G6464695680","display_name":null,"funder_award_id":"RR024146","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G6719544525","display_name":null,"funder_award_id":"UL1 RR024146","funder_id":"https://openalex.org/F4320332564","funder_display_name":"University of California, Davis"},{"id":"https://openalex.org/G7067410900","display_name":null,"funder_award_id":"DA024854","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7161627521","display_name":null,"funder_award_id":"HD02274","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G7274433319","display_name":"Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers","funder_award_id":"R01MH078041","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7418573391","display_name":null,"funder_award_id":"HD036071","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8312324571","display_name":null,"funder_award_id":"HD02274","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8340852147","display_name":null,"funder_award_id":"R40MC22641","funder_id":"https://openalex.org/F4320332175","funder_display_name":"Health Resources and Services Administration"},{"id":"https://openalex.org/G9000159210","display_name":null,"funder_award_id":"HD02274","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000315334","display_name":"Genotype-Phenotype Relationships in Fragile X Families","funder_award_id":"R01HD036071","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332175","display_name":"Health Resources and Services Administration","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320332564","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007289008.pdf","grobid_xml":"https://content.openalex.org/works/W2007289008.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1574171251","https://openalex.org/W1935785240","https://openalex.org/W1966392493","https://openalex.org/W1972762736","https://openalex.org/W1972885462","https://openalex.org/W1978522713","https://openalex.org/W1981501248","https://openalex.org/W1988453270","https://openalex.org/W1989442204","https://openalex.org/W1997085737","https://openalex.org/W1997956248","https://openalex.org/W2001855838","https://openalex.org/W2001970848","https://openalex.org/W2002364516","https://openalex.org/W2004772569","https://openalex.org/W2007759334","https://openalex.org/W2015743906","https://openalex.org/W2018620142","https://openalex.org/W2019879347","https://openalex.org/W2020352503","https://openalex.org/W2022372660","https://openalex.org/W2023122132","https://openalex.org/W2023894260","https://openalex.org/W2032702335","https://openalex.org/W2040316692","https://openalex.org/W2043576181","https://openalex.org/W2045203721","https://openalex.org/W2047894110","https://openalex.org/W2050324453","https://openalex.org/W2052326665","https://openalex.org/W2054091111","https://openalex.org/W2059303453","https://openalex.org/W2059455030","https://openalex.org/W2060412896","https://openalex.org/W2060911896","https://openalex.org/W2086398583","https://openalex.org/W2092456666","https://openalex.org/W2097218637","https://openalex.org/W2103148582","https://openalex.org/W2105912717","https://openalex.org/W2109229404","https://openalex.org/W2109713134","https://openalex.org/W2111428173","https://openalex.org/W2116045482","https://openalex.org/W2116795013","https://openalex.org/W2117342187","https://openalex.org/W2117874342","https://openalex.org/W2119868010","https://openalex.org/W2124161234","https://openalex.org/W2126487937","https://openalex.org/W2133565799","https://openalex.org/W2139900098","https://openalex.org/W2147909291","https://openalex.org/W2149919973","https://openalex.org/W2165896210","https://openalex.org/W2166329705","https://openalex.org/W2167197543","https://openalex.org/W2172051343","https://openalex.org/W2323051846","https://openalex.org/W2555442611","https://openalex.org/W2617738364","https://openalex.org/W3022868799"],"related_works":["https://openalex.org/W7096274810","https://openalex.org/W2518541914","https://openalex.org/W2210529468","https://openalex.org/W2986093041","https://openalex.org/W2740438840","https://openalex.org/W2466831397","https://openalex.org/W3095220231","https://openalex.org/W2588443622","https://openalex.org/W3097858165","https://openalex.org/W4239365958"],"abstract_inverted_index":{"Young":[0],"children":[1,27,45,65,105,119,207],"with":[2,23,34,46,109,124,183,208],"fragile":[3],"X":[4],"syndrome":[5],"(FXS)":[6],"often":[7],"experience":[8],"anxiety,":[9,70],"irritability,":[10],"and":[11,61,77,111,146,158,170,188],"hyperactivity":[12],"related":[13],"to":[14,88,117,139,149],"sensory":[15],"hyperarousal.":[16],"However,":[17],"there":[18],"are":[19],"no":[20],"medication":[21],"recommendations":[22],"documented":[24],"efficacy":[25],"for":[26,43,59,156,198],"under":[28],"5":[29],"years":[30],"old":[31],"of":[32,55,69,92,165,202],"age":[33],"FXS.":[35,209],"We":[36],"examined":[37],"data":[38,194],"through":[39],"a":[40,199],"chart":[41,127],"review":[42],"45":[44],"FXS,":[47],"12-50":[48],"months":[49,141,151],"old,":[50],"using":[51],"the":[52,178,196],"Mullen":[53],"Scales":[54],"Early":[56],"Learning":[57],"(MSEL)":[58],"baseline":[60,130],"longitudinal":[62],"assessments.":[63],"All":[64],"had":[66],"clinical":[67],"level":[68],"language":[71,172],"delays":[72],"based":[73],"on":[74],"MSEL":[75],"scores,":[76],"similar":[78,98],"early":[79],"learning":[80],"composite":[81],"(ELC)":[82],"scores":[83],"at":[84,134],"their":[85],"first":[86],"visit":[87],"our":[89],"clinic.":[90],"Incidence":[91],"autism":[93],"spectrum":[94],"disorder":[95],"(ASD)":[96],"was":[97,174,181],"in":[99,167,177,205],"both":[100,168],"groups.":[101],"There":[102],"were":[103,107,114,121,132],"11":[104],"who":[106,120,180],"treated":[108,123,157,160,182],"sertraline,":[110],"these":[112],"patients":[113],"retrospectively":[115],"compared":[116],"34":[118],"not":[122,159],"sertraline":[125,184,203],"by":[126],"review.":[128],"The":[129],"assessments":[131],"done":[133],"ages":[135],"ranging":[136],"from":[137,147],"18":[138],"44":[140],"(mean":[142,152],"26.9,":[143],"SD":[144,154],"7.99)":[145],"12":[148],"50":[150],"29.94,":[153],"8.64)":[155],"groups,":[161],"respectively.":[162],"Mean":[163],"rate":[164],"improvement":[166],"expressive":[169],"receptive":[171],"development":[173],"significantly":[175],"higher":[176],"group":[179],"(P":[185],"<":[186],"0.0001":[187],"P":[189],"=":[190],"0.0071,":[191],"resp.).":[192],"This":[193],"supports":[195],"need":[197],"controlled":[200],"trial":[201],"treatment":[204],"young":[206]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}