{"id":"https://openalex.org/W2007287727","doi":"https://doi.org/10.1016/j.semradonc.2004.04.008","title":"Tumor microenvironmental physiology and its implications for radiation oncology","display_name":"Tumor microenvironmental physiology and its implications for radiation oncology","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2007287727","doi":"https://doi.org/10.1016/j.semradonc.2004.04.008","mag":"2007287727","pmid":"https://pubmed.ncbi.nlm.nih.gov/15254862"},"language":"en","primary_location":{"id":"doi:10.1016/j.semradonc.2004.04.008","doi":"https://doi.org/10.1016/j.semradonc.2004.04.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semradonc.2004.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S104833954","display_name":"Seminars in Radiation Oncology","issn_l":"1053-4296","issn":["1053-4296","1532-9461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Radiation Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2007287727"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078928066","display_name":"Peter W. Vaupel","orcid":"https://orcid.org/0000-0003-4238-3188","observed_orcids":["https://orcid.org/0000-0003-4238-3188"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Peter Vaupel","raw_affiliation_strings":["Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078928066"],"corresponding_institution_ids":["https://openalex.org/I197323543"],"apc_list":{"value":3330,"currency":"USD","value_usd":3330},"apc_paid":null,"fwci":2.2554,"has_fulltext":false,"cited_by_count":971,"citation_normalized_percentile":{"value":0.91493056,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"14","issue":"3","first_page":"198","last_page":"206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8679999709129333},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8240000009536743},{"id":"https://openalex.org/keywords/extracellular-acidosis","display_name":"extracellular acidosis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.8920000195503235},{"id":"https://openalex.org/keywords/microcirculation","display_name":"microcirculation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7609999775886536},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/pre-treatment-assessment","display_name":"pre-treatment assessment","score":0.6880000233650208},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.8820000290870667},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7566537857055664},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6742061376571655},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6381962299346924},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6086976528167725},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5526778697967529},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5451028943061829},{"id":"https://openalex.org/C2779081379","wikidata":"https://www.wikidata.org/wiki/Q7852677","display_name":"Tumor hypoxia","level":3,"score":0.5373128652572632},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4935990571975708},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4757021367549896},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4488895833492279},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3547394871711731},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3328641653060913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.331548273563385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30514782667160034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2957339882850647},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19872698187828064},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19398698210716248},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19164779782295227},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.1852964162826538},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.10693767666816711},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semradonc.2004.04.008","doi":"https://doi.org/10.1016/j.semradonc.2004.04.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semradonc.2004.04.008","pdf_url":null,"source":{"id":"https://openalex.org/S104833954","display_name":"Seminars in Radiation Oncology","issn_l":"1053-4296","issn":["1053-4296","1532-9461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Radiation Oncology","raw_type":"journal-article"},{"id":"pmid:15254862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15254862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in radiation oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W33354229","https://openalex.org/W119579464","https://openalex.org/W122518273","https://openalex.org/W149336259","https://openalex.org/W184148271","https://openalex.org/W1495509342","https://openalex.org/W1511067168","https://openalex.org/W1513230168","https://openalex.org/W1536864538","https://openalex.org/W1547961512","https://openalex.org/W1631673212","https://openalex.org/W1941028255","https://openalex.org/W1956944003","https://openalex.org/W1967304777","https://openalex.org/W1967736783","https://openalex.org/W1973341878","https://openalex.org/W1975055461","https://openalex.org/W1986377299","https://openalex.org/W1987588336","https://openalex.org/W1987970382","https://openalex.org/W1998491010","https://openalex.org/W2008659053","https://openalex.org/W2014822355","https://openalex.org/W2041585886","https://openalex.org/W2046687522","https://openalex.org/W2047676254","https://openalex.org/W2053663198","https://openalex.org/W2061109295","https://openalex.org/W2070266075","https://openalex.org/W2070385942","https://openalex.org/W2071393494","https://openalex.org/W2072642889","https://openalex.org/W2079839060","https://openalex.org/W2083437069","https://openalex.org/W2083789958","https://openalex.org/W2084486398","https://openalex.org/W2090644963","https://openalex.org/W2091130738","https://openalex.org/W2102876452","https://openalex.org/W2106788165","https://openalex.org/W2107806932","https://openalex.org/W2110155388","https://openalex.org/W2116150717","https://openalex.org/W2124749273","https://openalex.org/W2125257427","https://openalex.org/W2142765712","https://openalex.org/W2144009262","https://openalex.org/W2157422038","https://openalex.org/W2157607856","https://openalex.org/W2170914860","https://openalex.org/W2416026182","https://openalex.org/W2478225583","https://openalex.org/W2483835277","https://openalex.org/W2488671727","https://openalex.org/W4254138975","https://openalex.org/W6630833197","https://openalex.org/W6646932601","https://openalex.org/W7027022900"],"related_works":["https://openalex.org/W2326609405","https://openalex.org/W2045292603","https://openalex.org/W40406324","https://openalex.org/W1980115517","https://openalex.org/W2796876009","https://openalex.org/W2039248250","https://openalex.org/W3130838210","https://openalex.org/W1536864538","https://openalex.org/W2076781747","https://openalex.org/W2109294354"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":44},{"year":2022,"cited_by_count":62},{"year":2021,"cited_by_count":48},{"year":2020,"cited_by_count":50},{"year":2019,"cited_by_count":51},{"year":2018,"cited_by_count":43},{"year":2017,"cited_by_count":54},{"year":2016,"cited_by_count":40},{"year":2015,"cited_by_count":54},{"year":2014,"cited_by_count":71},{"year":2013,"cited_by_count":58},{"year":2012,"cited_by_count":60}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}