{"id":"https://openalex.org/W2007287447","doi":"https://doi.org/10.1179/1743132813y.0000000311","title":"Electrophysiological evidence on epileptiform activity enhanced by electrical stimulation of teeth in rats","display_name":"Electrophysiological evidence on epileptiform activity enhanced by electrical stimulation of teeth in rats","publication_year":2014,"publication_date":"2014-01-14","ids":{"openalex":"https://openalex.org/W2007287447","doi":"https://doi.org/10.1179/1743132813y.0000000311","mag":"2007287447","pmid":"https://pubmed.ncbi.nlm.nih.gov/24620974"},"language":"en","primary_location":{"id":"doi:10.1179/1743132813y.0000000311","doi":"https://doi.org/10.1179/1743132813y.0000000311","is_oa":false,"landing_page_url":"https://doi.org/10.1179/1743132813y.0000000311","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052178715","display_name":"K\u00fcr\u015fat Er","orcid":"https://orcid.org/0000-0002-0667-4909","observed_orcids":["https://orcid.org/0000-0002-0667-4909"]},"institutions":[{"id":"https://openalex.org/I197907453","display_name":"Akdeniz University","ror":"https://ror.org/01m59r132","country_code":"TR","type":"education","lineage":["https://openalex.org/I197907453"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"K\u00fcr\u015fat Er","raw_affiliation_strings":["Faculty of DentistryDepartment of Endodontics, Akdeniz University, Antalya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of DentistryDepartment of Endodontics, Akdeniz University, Antalya, Turkey","institution_ids":["https://openalex.org/I197907453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033021417","display_name":"Mehmet Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0003-1798-5478","observed_orcids":["https://orcid.org/0000-0003-1798-5478"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Yildirim","raw_affiliation_strings":["Faculty of MedicineDepartment of Physiology, Karadeniz Technical University, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of MedicineDepartment of Physiology, Karadeniz Technical University, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078068129","display_name":"Tamer Ta\u015fdemir","orcid":"https://orcid.org/0000-0001-8512-5280","observed_orcids":["https://orcid.org/0000-0001-8512-5280"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tamer Ta\u015fdemir","raw_affiliation_strings":["Faculty of DentistryDepartment of Endodontics, Karadeniz Technical University, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of DentistryDepartment of Endodontics, Karadeniz Technical University, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017759658","display_name":"Metehan Ak\u00e7a","orcid":"https://orcid.org/0000-0003-0500-920X","observed_orcids":["https://orcid.org/0000-0003-0500-920X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Metehan Akca","raw_affiliation_strings":["Faculty of MedicineDepartment of Physiology, Karadeniz Technical University, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of MedicineDepartment of Physiology, Karadeniz Technical University, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000194396","display_name":"\u0130smail Abidin","orcid":"https://orcid.org/0000-0003-2510-9718","observed_orcids":["https://orcid.org/0000-0003-2510-9718"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ismail Abidin","raw_affiliation_strings":["Faculty of MedicineDepartment of Biophysics, Karadeniz Technical University, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of MedicineDepartment of Biophysics, Karadeniz Technical University, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052178715"],"corresponding_institution_ids":["https://openalex.org/I197907453"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.11887248,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"36","issue":"7","first_page":"673","last_page":"678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/penicillin-induced-epilepsy","display_name":"penicillin-induced epilepsy","score":0.875},{"id":"https://openalex.org/keywords/electrocorticography","display_name":"electrocorticography","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tooth-pulp-stimulation","display_name":"tooth pulp stimulation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/spike-rate","display_name":"spike frequency","score":0.46299999952316284},{"id":"https://openalex.org/keywords/spike-amplitude","display_name":"spike amplitude","score":0.5260000228881836},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.766339898109436},{"id":"https://openalex.org/C2780117969","wikidata":"https://www.wikidata.org/wiki/Q3587624","display_name":"Electrocorticography","level":3,"score":0.7095504999160767},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6972078084945679},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.6090278625488281},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5648698210716248},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.47988903522491455},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4237311780452728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39227908849716187},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3852122724056244},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3320757746696472},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31665027141571045},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014070","descriptor_name":"Tooth","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1179/1743132813y.0000000311","doi":"https://doi.org/10.1179/1743132813y.0000000311","is_oa":false,"landing_page_url":"https://doi.org/10.1179/1743132813y.0000000311","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},{"id":"pmid:24620974","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24620974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1497120823","https://openalex.org/W1902616579","https://openalex.org/W1970930372","https://openalex.org/W1974051079","https://openalex.org/W1986367006","https://openalex.org/W1988853641","https://openalex.org/W1998020542","https://openalex.org/W2016854448","https://openalex.org/W2022034453","https://openalex.org/W2051282584","https://openalex.org/W2054649225","https://openalex.org/W2063272042","https://openalex.org/W2064514965","https://openalex.org/W2086762859","https://openalex.org/W2111359830","https://openalex.org/W2111874429","https://openalex.org/W2124012173","https://openalex.org/W2124416664","https://openalex.org/W2130721272","https://openalex.org/W2134753525","https://openalex.org/W2140905120","https://openalex.org/W2169599134","https://openalex.org/W2171224790","https://openalex.org/W4249933270"],"related_works":["https://openalex.org/W7029175490","https://openalex.org/W313866802","https://openalex.org/W76679985","https://openalex.org/W971278408","https://openalex.org/W2059686755","https://openalex.org/W2967874650","https://openalex.org/W1993647035","https://openalex.org/W2340836978","https://openalex.org/W1948754612","https://openalex.org/W3205202599"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,11,15,56,67,82,109,163,174,193,200,213,235,237],"this":[3,225],"study":[4],"was":[5,24,51,116,119,151,157,205],"to":[6,61,231],"evaluate":[7,232],"the":[8,62,80,107,130,149,154,160,181,190,194,198,201,233],"possible":[9],"effects":[10,234],"electrical":[12,57],"stimulation":[13],"(ES)":[14],"tooth":[16,214,238],"on":[17,26,242],"penicillin-induced":[18],"epileptiform":[19,114,144,164,220],"activity":[20,115,145,165,221],"in":[21,79,127,146,167,189,222],"rats.":[22,32,223],"Experiment":[23],"realized":[25],"24":[27],"adult":[28],"male":[29],"Sprague":[30],"Dawley":[31],"Rats":[33],"were":[34,59,77,92,102,124,132],"assigned":[35],"three":[36],"groups":[37],"[stimulation":[38],"group":[39,42,46],"(SG),":[40],"penicillin":[41],"(PG),":[43],"and":[44,95,105,121,246],"penicillin+stimulation":[45],"(PSG)].":[47],"In":[48,98,111],"SG,":[49],"ES":[50,118,212,236],"only":[52],"applied.":[53],"Ten":[54],"pulses":[55],"current":[58,184,217],"delivered":[60],"teeth":[63],"for":[64,239],"a":[65,74,168],"duration":[66],"2":[68],"milliseconds":[69],"at":[70],"1-second":[71],"intervals":[72],"from":[73],"stimulator.":[75],"Currents":[76],"applied":[78,120],"range":[81],"40-240":[83],"\u03bcA":[84,87,176],"with":[85,134,153,197,215],"40":[86],"steps.":[88],"Electrocorticography":[89],"(ECoG)":[90],"recordings":[91,101,123],"taken":[93,103,125],"before":[94,104],"after":[96,113,172],"ES.":[97],"PG,":[99,202],"ECoG":[100,122],"during":[106],"injection":[108],"penicillin.":[110],"PSG,":[112],"induced,":[117],"as":[126],"SG.":[128,147],"All":[129],"data":[131],"analyzed":[133],"Student's":[135],"t":[136],"test.":[137],"Applied":[138],"currents":[139],"did":[140],"not":[141,206],"cause":[142],"any":[143],"When":[148],"PSG":[150,195],"compared":[152,196],"PG":[155],"it":[156,204],"seen":[158],"that":[159,211],"spike":[161,191],"frequency":[162],"increased":[166],"statistically":[169,207],"significant":[170],"way":[171],"application":[173,185],"240":[175],"(P":[177],"<":[178],"0\u00b705).":[179],"On":[180],"other":[182],"hand":[183],"caused":[186],"an":[187],"increase":[188],"amplitude":[192,199],"but":[203],"significant.":[208],"We":[209],"concluded":[210],"high":[216],"can":[218],"trigger":[219],"For":[224],"reason,":[226],"further":[227],"research":[228],"is":[229],"required":[230],"pulp":[240],"testing":[241],"epileptic":[243],"human":[244],"subjects":[245],"antiepileptic":[247],"drug":[248],"users.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}