{"id":"https://openalex.org/W2007287053","doi":"https://doi.org/10.1016/j.bmcl.2005.03.100","title":"Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters","display_name":"Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters","publication_year":2005,"publication_date":"2005-04-28","ids":{"openalex":"https://openalex.org/W2007287053","doi":"https://doi.org/10.1016/j.bmcl.2005.03.100","mag":"2007287053","pmid":"https://pubmed.ncbi.nlm.nih.gov/15911262"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2005.03.100","doi":"https://doi.org/10.1016/j.bmcl.2005.03.100","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.03.100","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040571641","display_name":"Sheo Bux Singh","orcid":"https://orcid.org/0000-0002-6393-3583","observed_orcids":["https://orcid.org/0000-0002-6393-3583"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sheo B. Singh","raw_affiliation_strings":["Merck Research Laboratories, Rahway, NJ 07065, USA. sheo_singh@merck.com","Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, Rahway, NJ 07065, USA. sheo_singh@merck.com","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082722387","display_name":"John G. Ondeyka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Ondeyka","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100620770","display_name":"Weiguo Liu","orcid":"https://orcid.org/0000-0001-5916-9837","observed_orcids":["https://orcid.org/0000-0001-5916-9837"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiguo Liu","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067729086","display_name":"Steve Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Chen","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059879334","display_name":"Tom S. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom S. Chen","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434132","display_name":"Xiaohua Li","orcid":"https://orcid.org/0000-0003-3490-916X","observed_orcids":["https://orcid.org/0000-0003-3490-916X"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohua Li","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086381659","display_name":"Aileen Bouffard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aileen Bouffard","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067375742","display_name":"James F. Dropinski","orcid":"https://orcid.org/0000-0001-7639-6476","observed_orcids":["https://orcid.org/0000-0001-7639-6476"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Dropinski","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069104736","display_name":"A. Brian Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Brian Jones","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053616339","display_name":"Sherrie X McCormick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sherrie McCormick","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104073882","display_name":"Nancy S. Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Hayes","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420023","display_name":"Jianhua Wang","orcid":"https://orcid.org/0000-0001-6831-9593","observed_orcids":["https://orcid.org/0000-0001-6831-9593"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhua Wang","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101984662","display_name":"Neelam Sharma","orcid":"https://orcid.org/0000-0002-5200-7330","observed_orcids":["https://orcid.org/0000-0002-5200-7330"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelam Sharma","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082030261","display_name":"Karen L. MacNaul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen MacNaul","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111819817","display_name":"Melba Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melba Hernandez","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108410657","display_name":"Yu\u2010Sheng Chao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Sheng Chao","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006577558","display_name":"Joanne Baffic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne Baffic","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062803193","display_name":"My\u2010Hanh Lam","orcid":"https://orcid.org/0000-0003-0270-7117","observed_orcids":["https://orcid.org/0000-0003-0270-7117"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"My-Hanh Lam","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018520175","display_name":"Charlotte A. Burton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Burton","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027061173","display_name":"Carl P. Sparrow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl P. Sparrow","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109863404","display_name":"John G. Menke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Menke","raw_affiliation_strings":["Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA","institution_ids":["https://openalex.org/I1285764155"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040571641"],"corresponding_institution_ids":["https://openalex.org/I1285764155"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.8657,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.63843487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"15","issue":"11","first_page":"2824","last_page":"2828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-x-receptor","display_name":"liver X receptor","score":0.8059999942779541},{"id":"https://openalex.org/keywords/podocarpic-acid","display_name":"podocarpic acid","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lxr-agonists","display_name":"LXR agonists","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7429999709129333},{"id":"https://openalex.org/keywords/oxysterols","display_name":"oxysterols","score":0.7459999918937683},{"id":"https://openalex.org/keywords/abca1","display_name":"ABCA1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cholesterol-efflux","display_name":"cholesterol efflux","score":0.8460000157356262},{"id":"https://openalex.org/keywords/dimeric-ligands","display_name":"dimeric ligands","score":0.6830000281333923},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.6000000238418579},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9290000200271606},{"id":"https://openalex.org/keywords/nuclear-receptor-ligands","display_name":"nuclear receptor ligands","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C167400880","wikidata":"https://www.wikidata.org/wiki/Q3454539","display_name":"Liver X receptor","level":5,"score":0.9043891429901123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8461461663246155},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.7331205606460571},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6507716178894043},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5631168484687805},{"id":"https://openalex.org/C76591681","wikidata":"https://www.wikidata.org/wiki/Q18034995","display_name":"Liver X receptor alpha","level":5,"score":0.47728481888771057},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45082709193229675},{"id":"https://openalex.org/C89951826","wikidata":"https://www.wikidata.org/wiki/Q1671731","display_name":"Inverse agonist","level":4,"score":0.4492069482803345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4476824104785919},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.41817405819892883},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.411262571811676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3524200916290283},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.22253888845443726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09422832727432251},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06532937288284302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmcl.2005.03.100","doi":"https://doi.org/10.1016/j.bmcl.2005.03.100","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2005.03.100","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:15911262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15911262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1968370020","https://openalex.org/W1980352486","https://openalex.org/W1982715024","https://openalex.org/W1996168740","https://openalex.org/W2017072034","https://openalex.org/W2081536949","https://openalex.org/W2086317930","https://openalex.org/W2088436733","https://openalex.org/W2112632255","https://openalex.org/W2135007868","https://openalex.org/W2137188051","https://openalex.org/W2153673003","https://openalex.org/W2171929751"],"related_works":["https://openalex.org/W2069809376","https://openalex.org/W2137188051","https://openalex.org/W2621198975","https://openalex.org/W1990693017","https://openalex.org/W2079416900","https://openalex.org/W2164516421","https://openalex.org/W2373358298","https://openalex.org/W2147153421","https://openalex.org/W3000704614","https://openalex.org/W2034339368"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
