{"id":"https://openalex.org/W2007284051","doi":"https://doi.org/10.1074/jbc.m113.519421","title":"The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain","display_name":"The Molecular Chaperone Hsp70 Activates Protein Phosphatase 5 (PP5) by Binding the Tetratricopeptide Repeat (TPR) Domain","publication_year":2013,"publication_date":"2013-12-11","ids":{"openalex":"https://openalex.org/W2007284051","doi":"https://doi.org/10.1074/jbc.m113.519421","mag":"2007284051","pmid":"https://pubmed.ncbi.nlm.nih.gov/24327656"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m113.519421","doi":"https://doi.org/10.1074/jbc.m113.519421","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.519421","pdf_url":"http://www.jbc.org/article/S002192581974811X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192581974811X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085456274","display_name":"Jamie N. Connarn","orcid":"https://orcid.org/0000-0001-7112-7357","observed_orcids":["https://orcid.org/0000-0001-7112-7357"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie N. Connarn","raw_affiliation_strings":["From the Departments of Pharmaceutical Sciences","Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Pharmaceutical Sciences","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003523390","display_name":"Victoria A. Assimon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria A. Assimon","raw_affiliation_strings":["the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011784951","display_name":"Rebecca A. Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Reed","raw_affiliation_strings":["the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029614000","display_name":"Eric Tse","orcid":"https://orcid.org/0000-0002-2082-9006","observed_orcids":["https://orcid.org/0000-0002-2082-9006"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Tse","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073454413","display_name":"Daniel R. Southworth","orcid":"https://orcid.org/0000-0001-7108-9389","observed_orcids":["https://orcid.org/0000-0001-7108-9389"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel R. Southworth","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009411980","display_name":"Erik R. P. Zuiderweg","orcid":"https://orcid.org/0000-0001-6766-6446","observed_orcids":["https://orcid.org/0000-0001-6766-6446"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik R.P. Zuiderweg","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067529915","display_name":"Jason E. Gestwicki","orcid":"https://orcid.org/0000-0002-6125-3154","observed_orcids":["https://orcid.org/0000-0002-6125-3154"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. Gestwicki","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109","the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069778809","display_name":"Duxin Sun","orcid":"https://orcid.org/0000-0002-6406-2126","observed_orcids":["https://orcid.org/0000-0002-6406-2126"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Duxin Sun","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109","the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"the Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069778809"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.7485,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.83922652,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"289","issue":"5","first_page":"2908","last_page":"2917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-phosphatase-5","display_name":"protein phosphatase 5","score":0.921999990940094},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.9639999866485596},{"id":"https://openalex.org/keywords/tetratricopeptide-repeat-domain","display_name":"tetratricopeptide repeat domain","score":0.9559999704360962},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.5849999785423279},{"id":"https://openalex.org/keywords/phosphatase-activation","display_name":"phosphatase activation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hsc70","display_name":"Hsc70","score":0.7620000243186951},{"id":"https://openalex.org/keywords/intrinsically-disordered-regions","display_name":"intrinsically disordered regions","score":0.6039999723434448},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dephosphorylation","display_name":"dephosphorylation","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C188018408","wikidata":"https://www.wikidata.org/wiki/Q24779822","display_name":"Tetratricopeptide","level":3,"score":0.9922268986701965},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.6261003017425537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5347679257392883},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5264179110527039},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4644112288951874},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.46296265721321106},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.46009179949760437},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.45404306054115295},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.4513694941997528},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42174673080444336},{"id":"https://openalex.org/C25166345","wikidata":"https://www.wikidata.org/wiki/Q4914012","display_name":"Binding domain","level":3,"score":0.42166462540626526},{"id":"https://openalex.org/C115867849","wikidata":"https://www.wikidata.org/wiki/Q753175","display_name":"Protein-fragment complementation assay","level":5,"score":0.41570472717285156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3716558516025543},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3096115291118622},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.2794235348701477},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.163492351770401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06722411513328552},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054730","descriptor_name":"Protein Interaction Domains and Motifs","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m113.519421","doi":"https://doi.org/10.1074/jbc.m113.519421","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.519421","pdf_url":"http://www.jbc.org/article/S002192581974811X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:24327656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24327656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3275149","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3908423","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3908423","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3908423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6qb96776","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6qb96776","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry, vol 289, iss 5","raw_type":"article"},{"id":"doi:10.7270/q2gh9gsn","doi":"https://doi.org/10.7270/q2gh9gsn","is_oa":true,"landing_page_url":"https://doi.org/10.7270/q2gh9gsn","pdf_url":null,"source":{"id":"https://openalex.org/S7407050887","display_name":"UC San Diego","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36258959","host_organization_name":"University of California San Diego","host_organization_lineage":["https://openalex.org/I36258959"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1074/jbc.m113.519421","doi":"https://doi.org/10.1074/jbc.m113.519421","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m113.519421","pdf_url":"http://www.jbc.org/article/S002192581974811X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6225488865","display_name":null,"funder_award_id":"F31 AG043266","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G829705972","display_name":null,"funder_award_id":"R01-CA120023","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000892101","display_name":"Molecular Chaperones and Small Molecules","funder_award_id":"R01NS059690","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007284051.pdf","grobid_xml":"https://content.openalex.org/works/W2007284051.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W38652107","https://openalex.org/W1492302030","https://openalex.org/W1605149529","https://openalex.org/W1955276614","https://openalex.org/W1967169977","https://openalex.org/W1971540712","https://openalex.org/W1972353893","https://openalex.org/W1983211885","https://openalex.org/W1985648234","https://openalex.org/W1987644496","https://openalex.org/W1990292742","https://openalex.org/W1991359253","https://openalex.org/W1992511009","https://openalex.org/W1998571837","https://openalex.org/W2004543547","https://openalex.org/W2012512233","https://openalex.org/W2014294043","https://openalex.org/W2018886962","https://openalex.org/W2042838776","https://openalex.org/W2045987477","https://openalex.org/W2046811359","https://openalex.org/W2051894528","https://openalex.org/W2052419732","https://openalex.org/W2067804796","https://openalex.org/W2067922693","https://openalex.org/W2082140468","https://openalex.org/W2086353001","https://openalex.org/W2089271742","https://openalex.org/W2091520144","https://openalex.org/W2103854266","https://openalex.org/W2106714479","https://openalex.org/W2109936231","https://openalex.org/W2117581689","https://openalex.org/W2126581529","https://openalex.org/W2127284685","https://openalex.org/W2142297263","https://openalex.org/W2146149989","https://openalex.org/W2156510247","https://openalex.org/W2165301262","https://openalex.org/W2165408960","https://openalex.org/W2326010744"],"related_works":["https://openalex.org/W1968235572","https://openalex.org/W1980595299","https://openalex.org/W2805100915","https://openalex.org/W2152044968","https://openalex.org/W1670058493","https://openalex.org/W2121069774","https://openalex.org/W4234868888","https://openalex.org/W1978495222","https://openalex.org/W2326450921","https://openalex.org/W4317241398"],"abstract_inverted_index":{"Protein":[0],"phosphatase":[1,25,90,186],"5":[2],"(PP5)":[3],"is":[4,155],"auto-inhibited":[5],"by":[6,138],"intramolecular":[7],"interactions":[8],"with":[9,108,115,117,168,199],"its":[10,24,185],"tetratricopeptide":[11],"repeat":[12],"(TPR)":[13],"domain.":[14],"Hsp90":[15,47,65],"has":[16],"been":[17],"shown":[18],"to":[19,22,34,51,69,86,157,160],"bind":[20,50],"PP5":[21,35,52,74,87,93,102,119,130,159,182,193],"activate":[23],"activity.":[26],"However,":[27,83],"the":[28,70,95,111,121,144,148],"functional":[29],"implications":[30],"of":[31,73,92,97,165,171],"binding":[32,85,96,120,154],"Hsp70":[33,49,80,84,180],"are":[36,132],"not":[37],"yet":[38],"clear.":[39],"In":[40],"this":[41],"study,":[42],"we":[43],"find":[44,100],"that":[45,64,101,127,142,179,194],"both":[46],"and":[48,129,147,173,183,204],"using":[53],"a":[54,104,139,169],"luciferase":[55],"fragment":[56],"complementation":[57],"assay.":[58],"A":[59],"fluorescence":[60],"polarization":[61],"assay":[62],"shows":[63],"(MEEVD":[66],"motif)":[67],"binds":[68],"TPR":[71],"domain":[72],"almost":[75],"3-fold":[76],"higher":[77,89],"affinity":[78],"than":[79,94],"(IEEVD":[81],"motif).":[82],"stimulates":[88],"activity":[91,187],"Hsp90.":[98],"We":[99],"forms":[103],"stable":[105],"1:1":[106],"complex":[107],"Hsp70,":[109],"but":[110],"interaction":[112],"appears":[113],"asymmetric":[114],"Hsp90,":[116],"one":[118],"dimer.":[122],"Solution":[123],"NMR":[124],"studies":[125],"reveal":[126],"Hsc70":[128,145],"proteins":[131],"dynamically":[133],"independent":[134],"in":[135,202],"complex,":[136],"tethered":[137,153],"disordered":[140],"region":[141],"connects":[143],"core":[146],"IEEVD-TPR":[149],"contact":[150],"area.":[151],"This":[152],"expected":[156],"allow":[158],"carry":[161],"out":[162],"multi-site":[163],"dephosphorylation":[164],"Hsp70-bound":[166],"clients":[167],"range":[170],"sizes":[172],"shapes.":[174],"Together,":[175],"these":[176],"results":[177],"demonstrate":[178],"recruits":[181],"activates":[184],"which":[188],"suggests":[189],"dual":[190],"roles":[191],"for":[192],"might":[195],"link":[196],"chaperone":[197],"systems":[198],"signaling":[200],"pathways":[201],"cancer":[203],"development.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2016-06-24T00:00:00"}
