{"id":"https://openalex.org/W2007283637","doi":"https://doi.org/10.4161/cc.9.14.12346","title":"Fatty acids trigger mitochondrion-dependent necrosis","display_name":"Fatty acids trigger mitochondrion-dependent necrosis","publication_year":2010,"publication_date":"2010-07-15","ids":{"openalex":"https://openalex.org/W2007283637","doi":"https://doi.org/10.4161/cc.9.14.12346","mag":"2007283637","pmid":"https://pubmed.ncbi.nlm.nih.gov/20647771","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3040965"},"language":"en","primary_location":{"id":"doi:10.4161/cc.9.14.12346","doi":"https://doi.org/10.4161/cc.9.14.12346","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.14.12346","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.14.12346?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.14.12346?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074996521","display_name":"Patrick Rockenfeller","orcid":"https://orcid.org/0000-0002-1643-3885","observed_orcids":["https://orcid.org/0000-0002-1643-3885"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Patrick Rockenfeller","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007774954","display_name":"Julia Ring","orcid":"https://orcid.org/0000-0003-4991-9328","observed_orcids":["https://orcid.org/0000-0003-4991-9328"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Julia Ring","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059584291","display_name":"Vera Muschett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Vera Muschett","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053457658","display_name":"Andreas Beranek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4092182","display_name":"Graz University of Technology","ror":"https://ror.org/00d7xrm67","country_code":"AT","type":"education","lineage":["https://openalex.org/I4092182"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Beranek","raw_affiliation_strings":["Graz University of technology , Institute for Biochemistry ; \u00d6sterreich , Austria,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graz University of technology , Institute for Biochemistry ; \u00d6sterreich , Austria,","institution_ids":["https://openalex.org/I4092182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065101054","display_name":"Sabrina B\u00fcttner","orcid":"https://orcid.org/0000-0002-2786-8542","observed_orcids":["https://orcid.org/0000-0002-2786-8542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabrina B\u00fcttner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030912064","display_name":"Didac Carmona\u2010Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-7548-7771","observed_orcids":["https://orcid.org/0000-0001-7548-7771"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Didac Carmona-Gutierrez","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018303103","display_name":"Tobias Eisenberg","orcid":"https://orcid.org/0000-0003-3559-1130","observed_orcids":["https://orcid.org/0000-0003-3559-1130"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Tobias Eisenberg","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080713003","display_name":"Chamel M. Khoury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Chamel Khoury","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035832516","display_name":"Gerald N. Rechberger","orcid":"https://orcid.org/0000-0002-0071-317X","observed_orcids":["https://orcid.org/0000-0002-0071-317X"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerald Rechberger","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024468952","display_name":"Sepp Dieter Kohlwein","orcid":"https://orcid.org/0000-0002-1030-0598","observed_orcids":["https://orcid.org/0000-0002-1030-0598"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sepp D. Kohlwein","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075296559","display_name":"Guido Kroemer","orcid":"https://orcid.org/0000-0002-9334-4405","observed_orcids":["https://orcid.org/0000-0002-9334-4405"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guido Kroemer","raw_affiliation_strings":["INSeRM; U848 ; Institut Gustave Roussy ; paris , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSeRM; U848 ; Institut Gustave Roussy ; paris , France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2801843802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078054009","display_name":"Frank Madeo","orcid":"https://orcid.org/0000-0002-5070-1329","observed_orcids":["https://orcid.org/0000-0002-5070-1329"]},"institutions":[{"id":"https://openalex.org/I15766117","display_name":"University of Graz","ror":"https://ror.org/01faaaf77","country_code":"AT","type":"education","lineage":["https://openalex.org/I15766117"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Frank Madeo","raw_affiliation_strings":["University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Graz ; Institute for Molecular Biosciences ; \u00d6sterreich , Austria;","institution_ids":["https://openalex.org/I15766117"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078054009"],"corresponding_institution_ids":["https://openalex.org/I15766117"],"apc_list":null,"apc_paid":null,"fwci":3.3844,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.93113976,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"9","issue":"14","first_page":"2908","last_page":"2914"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.5870000123977661},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/triacylglycerol-lipase","display_name":"triacylglycerol lipase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cooking-oil","display_name":"cooking oil","score":0.8009999990463257},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.47600001096725464},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.39500001072883606},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.656000018119812},{"id":"https://openalex.org/keywords/non-apoptotic-cell-death","display_name":"non-apoptotic cell death","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.8843083381652832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.812821626663208},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6660928130149841},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6406545042991638},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.539764404296875},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.535418689250946},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5263515710830688},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.5122825503349304},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5011775493621826},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.48978376388549805},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4894598722457886},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4751817286014557},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.473954439163208},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3397766947746277},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2402915358543396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23338168859481812},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.20416581630706787},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.13571718335151672},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0962323248386383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/cc.9.14.12346","doi":"https://doi.org/10.4161/cc.9.14.12346","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.14.12346","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.14.12346?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2084946","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3040965","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3040965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3040965","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"Text"},{"id":"pmid:20647771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20647771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell cycle (Georgetown, Tex.)","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.4161/cc.9.14.12346","doi":"https://doi.org/10.4161/cc.9.14.12346","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cc.9.14.12346","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cc.9.14.12346?needAccess=true&role=button","source":{"id":"https://openalex.org/S86011449","display_name":"Cell Cycle","issn_l":"1538-4101","issn":["1538-4101","1551-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Cycle","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.49000000953674316,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086088190","display_name":null,"funder_award_id":"S9304-B05","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G661133386","display_name":"Oogenesis and Early Embryogenesis in Drosophila","funder_award_id":"R37HD015587","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007283637.pdf","grobid_xml":"https://content.openalex.org/works/W2007283637.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168310429","https://openalex.org/W4414536165","https://openalex.org/W1985008673","https://openalex.org/W1973860295","https://openalex.org/W2060129257","https://openalex.org/W4296993002","https://openalex.org/W2013570209","https://openalex.org/W1976315274","https://openalex.org/W7097744255","https://openalex.org/W2075665975"],"abstract_inverted_index":{"Obesity":[0],"is":[1,124],"characterized":[2],"by":[3,95],"lipid":[4,139],"accumulation":[5,115],"in":[6,53,59,61],"non-adipose":[7],"tissues,":[8],"leading":[9],"to":[10,32,89,113],"organ":[11],"degeneration":[12],"and":[13,23,78,100,111],"a":[14,65,127],"wide":[15],"range":[16],"of":[17,43,64,72,97,102,116,138],"diseases,":[18],"including":[19],"diabetes,":[20],"heart":[21],"attack,":[22],"liver":[24],"cirrhosis.":[25],"Free":[26],"fatty":[27],"acids":[28],"(FFA)":[29],"are":[30,141],"believed":[31],"be":[33],"the":[34,39,62,69,73,114,132,135],"principal":[35],"toxic":[36],"triggers":[37],"mediating":[38],"adverse":[40,136],"cellular":[41],"effects":[42,137],"lipids.":[44],"Here,":[45],"we":[46,82],"show":[47],"that":[48,84,122,134],"various":[49],"cooking":[50],"oils":[51],"used":[52],"human":[54],"nutrition":[55],"cause":[56],"cell":[57,79,91],"death":[58,80],"yeast":[60],"presence":[63],"triacylglycerol":[66],"lipase,":[67],"mimicking":[68],"physiological":[70],"microenvironment":[71],"small":[74],"intestine.":[75],"Combining":[76],"genetic":[77],"assays,":[81],"demonstrate":[83],"elevated":[85],"FFA":[86],"concentrations":[87],"lead":[88],"necrotic":[90,129],"death,":[92],"as":[93],"evidenced":[94],"loss":[96],"membrane":[98],"integrity":[99],"release":[101],"nuclear":[103],"HMGB1.":[104],"FFA-mediated":[105],"necrosis":[106],"depends":[107],"on":[108],"functional":[109],"mitochondria":[110],"leads":[112],"reactive":[117],"oxygen":[118],"species.":[119],"We":[120],"conclude":[121],"lipotoxicity":[123],"executed":[125],"via":[126],"mitochondrial":[128],"pathway,":[130],"challenging":[131],"dogma":[133],"stress":[140],"exclusively":[142],"apoptotic.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}