{"id":"https://openalex.org/W2007283165","doi":"https://doi.org/10.1523/jneurosci.4845-04.2005","title":"Locus Ceruleus Control of Slow-Wave Homeostasis","display_name":"Locus Ceruleus Control of Slow-Wave Homeostasis","publication_year":2005,"publication_date":"2005-05-04","ids":{"openalex":"https://openalex.org/W2007283165","doi":"https://doi.org/10.1523/jneurosci.4845-04.2005","mag":"2007283165","pmid":"https://pubmed.ncbi.nlm.nih.gov/15872097","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725032"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.4845-04.2005","doi":"https://doi.org/10.1523/jneurosci.4845-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4845-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/18/4503.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/25/18/4503.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024483689","display_name":"Chiara Cirelli","orcid":"https://orcid.org/0000-0003-2563-677X","observed_orcids":["https://orcid.org/0000-0003-2563-677X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Cirelli","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA. ccirelli@wisc.edu","Dept. of Psychiatry, University of Wisconsin/Madison, Madison, Wisconsin, 53719, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719, USA. ccirelli@wisc.edu","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Dept. of Psychiatry, University of Wisconsin/Madison, Madison, Wisconsin, 53719, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089840526","display_name":"Reto Huber","orcid":"https://orcid.org/0000-0002-1400-9466","observed_orcids":["https://orcid.org/0000-0002-1400-9466"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reto Huber","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104106489","display_name":"Anupama Gopalakrishnan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anupama Gopalakrishnan","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086936673","display_name":"Teresa L Southard","orcid":"https://orcid.org/0000-0001-8388-7951","observed_orcids":["https://orcid.org/0000-0001-8388-7951"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teresa L. Southard","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001381023","display_name":"Giulio Tononi","orcid":"https://orcid.org/0000-0002-3892-4087","observed_orcids":["https://orcid.org/0000-0002-3892-4087"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulio Tononi","raw_affiliation_strings":["Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Wisconsin, Madison, Madison, Wisconsin 53719","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":2.3187,"has_fulltext":true,"cited_by_count":119,"citation_normalized_percentile":{"value":0.86751079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"25","issue":"18","first_page":"4503","last_page":"4511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.9319999814033508},{"id":"https://openalex.org/keywords/slow-wave-activity","display_name":"slow-wave activity","score":0.906000018119812},{"id":"https://openalex.org/keywords/sleep-homeostasis","display_name":"sleep homeostasis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/norepinephrine-depletion","display_name":"norepinephrine depletion","score":0.921999990940094},{"id":"https://openalex.org/keywords/synaptic-potentiation","display_name":"synaptic potentiation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/sleep-need","display_name":"sleep need","score":0.6200000047683716},{"id":"https://openalex.org/keywords/wakefulness","display_name":"wakefulness","score":0.628000020980835},{"id":"https://openalex.org/keywords/nrem-sleep","display_name":"NREM sleep","score":0.9449999928474426},{"id":"https://openalex.org/keywords/sleep-wake-regulation","display_name":"sleep-wake regulation","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779320081","wikidata":"https://www.wikidata.org/wiki/Q246710","display_name":"Wakefulness","level":3,"score":0.9050856828689575},{"id":"https://openalex.org/C20566671","wikidata":"https://www.wikidata.org/wiki/Q1752878","display_name":"Non-rapid eye movement sleep","level":3,"score":0.7518510222434998},{"id":"https://openalex.org/C2909480419","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus Ceruleus","level":5,"score":0.7217276692390442},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.7196950316429138},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.66628497838974},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4843076765537262},{"id":"https://openalex.org/C29993825","wikidata":"https://www.wikidata.org/wiki/Q7002656","display_name":"Neuroscience of sleep","level":4,"score":0.4649708569049835},{"id":"https://openalex.org/C110539466","wikidata":"https://www.wikidata.org/wiki/Q3964845","display_name":"Slow-wave sleep","level":3,"score":0.4616353511810303},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.4247784912586212},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34266650676727295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28892165422439575},{"id":"https://openalex.org/C153050134","wikidata":"https://www.wikidata.org/wiki/Q760256","display_name":"Eye movement","level":2,"score":0.21912527084350586},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.18290960788726807},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1746029257774353},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15825888514518738},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1235203742980957},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07474935054779053},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.0},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001596","descriptor_name":"Benzylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012893","descriptor_name":"Sleep Wake Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012894","descriptor_name":"Sleep Stages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013057","descriptor_name":"Spectrum Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1523/jneurosci.4845-04.2005","doi":"https://doi.org/10.1523/jneurosci.4845-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4845-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/18/4503.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5689173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725032","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6725032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6725032","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:15872097","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15872097","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.1089","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.1089","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/25/18/4503.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.4845-04.2005","doi":"https://doi.org/10.1523/jneurosci.4845-04.2005","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.4845-04.2005","pdf_url":"https://www.jneurosci.org/content/jneuro/25/18/4503.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007283165.pdf","grobid_xml":"https://content.openalex.org/works/W2007283165.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W91622393","https://openalex.org/W120443349","https://openalex.org/W203417440","https://openalex.org/W1508825618","https://openalex.org/W1517722692","https://openalex.org/W1521227715","https://openalex.org/W1658103071","https://openalex.org/W1853766545","https://openalex.org/W1880379006","https://openalex.org/W1965171086","https://openalex.org/W1965668510","https://openalex.org/W1966577866","https://openalex.org/W1973627502","https://openalex.org/W1975615318","https://openalex.org/W1975749376","https://openalex.org/W1976669574","https://openalex.org/W1978861401","https://openalex.org/W1979428815","https://openalex.org/W1980144002","https://openalex.org/W1980545223","https://openalex.org/W1980850705","https://openalex.org/W1981637574","https://openalex.org/W1984200333","https://openalex.org/W1985181615","https://openalex.org/W1986311244","https://openalex.org/W1987590730","https://openalex.org/W1999001824","https://openalex.org/W2001834798","https://openalex.org/W2002596945","https://openalex.org/W2003106844","https://openalex.org/W2009199302","https://openalex.org/W2009362065","https://openalex.org/W2015340885","https://openalex.org/W2015785286","https://openalex.org/W2025009628","https://openalex.org/W2026619006","https://openalex.org/W2044715983","https://openalex.org/W2045815714","https://openalex.org/W2047083258","https://openalex.org/W2051507021","https://openalex.org/W2058974221","https://openalex.org/W2060392742","https://openalex.org/W2063062105","https://openalex.org/W2063094367","https://openalex.org/W2063451830","https://openalex.org/W2065428236","https://openalex.org/W2067851037","https://openalex.org/W2068613355","https://openalex.org/W2071215075","https://openalex.org/W2074548799","https://openalex.org/W2074804401","https://openalex.org/W2074905090","https://openalex.org/W2076224262","https://openalex.org/W2078337693","https://openalex.org/W2080043998","https://openalex.org/W2080537942","https://openalex.org/W2080659194","https://openalex.org/W2083143366","https://openalex.org/W2084313944","https://openalex.org/W2084911166","https://openalex.org/W2087143040","https://openalex.org/W2088011743","https://openalex.org/W2091331944","https://openalex.org/W2094316274","https://openalex.org/W2096352061","https://openalex.org/W2096799834","https://openalex.org/W2098170217","https://openalex.org/W2106859642","https://openalex.org/W2114956093","https://openalex.org/W2117373688","https://openalex.org/W2125337181","https://openalex.org/W2129250361","https://openalex.org/W2131507856","https://openalex.org/W2148625946","https://openalex.org/W2158151561","https://openalex.org/W2160154470","https://openalex.org/W2164078216","https://openalex.org/W2164153190","https://openalex.org/W2167981256","https://openalex.org/W2186124249","https://openalex.org/W2225249368","https://openalex.org/W2232931790","https://openalex.org/W2399025129","https://openalex.org/W2411345750","https://openalex.org/W2482280948","https://openalex.org/W2584975462","https://openalex.org/W4249604251","https://openalex.org/W4293082421","https://openalex.org/W4297833723"],"related_works":["https://openalex.org/W7098997615","https://openalex.org/W2560836000","https://openalex.org/W2138337223","https://openalex.org/W6983610880","https://openalex.org/W2124761808","https://openalex.org/W137630247","https://openalex.org/W2067277558","https://openalex.org/W2013825587","https://openalex.org/W2080659194","https://openalex.org/W7098305204"],"abstract_inverted_index":{"Sleep":[0],"intensity":[1,28],"is":[2,29,112,187],"regulated":[3],"by":[4,31,91],"the":[5,15,36,48,53,57,75,92,101,117,148,162,166,181,199,206],"duration":[6],"of":[7,18,59,95,103,109,119,150,165,184,201],"previous":[8],"wakefulness,":[9,82],"suggesting":[10],"that":[11,113,145,161,180,208],"waking":[12],"results":[13],"in":[14,35,45,77,100,124,134,136],"progressive":[16],"accumulation":[17,183],"sleep":[19,27,41,185,209],"need":[20,186],"(Borbely":[21],"and":[22,72,156,171,204],"Achermann,":[23],"2000).":[24],"In":[25],"mammals,":[26],"reflected":[30],"slow-wave":[32],"activity":[33],"(SWA)":[34],"nonrapid":[37],"eye":[38],"movement":[39],"(NREM)":[40],"electroencephalogram,":[42],"which":[43,137],"increases":[44],"proportion":[46],"to":[47,67,190,215],"time":[49],"spent":[50],"awake.":[51],"However,":[52],"mechanisms":[54],"responsible":[55],"for":[56],"increase":[58,76],"NREM":[60],"SWA":[61,78,127,132,168,210],"after":[62,174],"wakefulness":[63,154],"remain":[64],"unclear.":[65],"According":[66],"a":[68,125,143],"recent":[69],"hypothesis":[70,111,207],"(Tononi":[71],"Cirelli,":[73],"2003),":[74],"occurs":[79],"because":[80],"during":[81,153,218],"many":[83],"cortical":[84,138],"circuits":[85],"undergo":[86],"synaptic":[87,216],"potentiation,":[88],"as":[89,198],"evidenced":[90],"widespread":[93],"induction":[94,118,149,200],"long-term":[96],"potentiation":[97,217],"(LTP)-related":[98],"genes":[99,121,152],"brain":[102],"awake":[104],"animals.":[105],"A":[106],"direct":[107],"prediction":[108],"this":[110],"manipulations":[114],"interfering":[115],"with":[116],"LTP-related":[120,151,202],"should":[122],"result":[123],"blunted":[126],"response.":[128],"Here,":[129],"we":[130],"examined":[131],"response":[133,164],"rats":[135],"norepinephrine":[139],"(NA)":[140],"was":[141,169],"depleted,":[142],"manipulation":[144],"greatly":[146],"reduces":[147],"(Cirelli":[155],"Tononi,":[157],"2004).":[158],"We":[159],"found":[160],"homeostatic":[163],"lower-range":[167],"markedly":[170],"specifically":[172],"reduced":[173],"NA":[175,195],"depletion.":[176],"These":[177],"data":[178],"suggest":[179],"wake-dependent":[182],"causally":[188],"related":[189,214],"cellular":[191],"changes":[192],"dependent":[193],"on":[194],"release,":[196],"such":[197],"genes,":[203],"support":[205],"homeostasis":[211],"may":[212],"be":[213],"wakefulness.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}