{"id":"https://openalex.org/W2007276897","doi":"https://doi.org/10.1211/146080800128735539","title":"Synthesis of Some Unsymmetrical Ester Derivatives of \u03b3-(4-Substituted piperazin-1-yl)-\u03b1-phenyl propanols with Antispasmodic Activity","display_name":"Synthesis of Some Unsymmetrical Ester Derivatives of \u03b3-(4-Substituted piperazin-1-yl)-\u03b1-phenyl propanols with Antispasmodic Activity","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2007276897","doi":"https://doi.org/10.1211/146080800128735539","mag":"2007276897"},"language":"en","primary_location":{"id":"doi:10.1211/146080800128735539","doi":"https://doi.org/10.1211/146080800128735539","is_oa":false,"landing_page_url":"https://doi.org/10.1211/146080800128735539","pdf_url":null,"source":{"id":"https://openalex.org/S2235546","display_name":"Pharmacy and Pharmacology Communications","issn_l":"1460-8081","issn":["1460-8081","2047-9948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311640","host_organization_name":"Royal Pharmaceutical Society","host_organization_lineage":["https://openalex.org/P4310311640"],"host_organization_lineage_names":["Royal Pharmaceutical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacy and Pharmacology Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113174538","display_name":"Patience Ogoamaka Osadebe","orcid":"https://orcid.org/0000-0002-6684-018X","observed_orcids":["https://orcid.org/0000-0002-6684-018X"]},"institutions":[{"id":"https://openalex.org/I11892038","display_name":"University of Nigeria","ror":"https://ror.org/01sn1yx84","country_code":"NG","type":"education","lineage":["https://openalex.org/I11892038"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"P.O. Osadebe","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of Nigeria Nsukka, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of Nigeria Nsukka, Nigeria","institution_ids":["https://openalex.org/I11892038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108904737","display_name":"Peter A. Akah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11892038","display_name":"University of Nigeria","ror":"https://ror.org/01sn1yx84","country_code":"NG","type":"education","lineage":["https://openalex.org/I11892038"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"P.A. Akah","raw_affiliation_strings":["Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, University of Nigeria, Nsukka, Nigeria","institution_ids":["https://openalex.org/I11892038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113806115","display_name":"Charles O. Okafor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11892038","display_name":"University of Nigeria","ror":"https://ror.org/01sn1yx84","country_code":"NG","type":"education","lineage":["https://openalex.org/I11892038"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C.O. Okafor","raw_affiliation_strings":["Department of Pure and Industrial Chemistry University of Nigeria, Nsukka Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pure and Industrial Chemistry University of Nigeria, Nsukka Nigeria","institution_ids":["https://openalex.org/I11892038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028062878","display_name":"L. Natova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148616","display_name":"University of Chemical Technology and Metallurgy","ror":"https://ror.org/0402pty94","country_code":"BG","type":"education","lineage":["https://openalex.org/I4210148616"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"L. Natova","raw_affiliation_strings":["Higher Institute of Chemical Technology, Sofia, Bulgaria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Higher Institute of Chemical Technology, Sofia, Bulgaria","institution_ids":["https://openalex.org/I4210148616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10225159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"10","first_page":"471","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13876","display_name":"Chemical synthesis and pharmacological studies","score":0.1088000014424324,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ester-derivatives","display_name":"ester derivatives","score":0.7179999947547913},{"id":"https://openalex.org/keywords/antispasmodic-activity","display_name":"antispasmodic activity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/esterification","display_name":"esterification","score":0.6800000071525574},{"id":"https://openalex.org/keywords/solid-liquid-phase-transfer-catalysis","display_name":"solid-liquid phase transfer catalysis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/guinea-pig-ileum","display_name":"guinea pig ileum","score":0.847000002861023},{"id":"https://openalex.org/keywords/ethyl-esters","display_name":"ethyl esters","score":0.7409999966621399},{"id":"https://openalex.org/keywords/benzyl-esters","display_name":"benzyl esters","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nitrogen-determination","display_name":"nitrogen determination","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2776798904","wikidata":"https://www.wikidata.org/wiki/Q93978","display_name":"Antispasmodic","level":2,"score":0.9738417863845825},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5615461468696594},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4157399535179138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19193395972251892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12878203392028809}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1211/146080800128735539","doi":"https://doi.org/10.1211/146080800128735539","is_oa":false,"landing_page_url":"https://doi.org/10.1211/146080800128735539","pdf_url":null,"source":{"id":"https://openalex.org/S2235546","display_name":"Pharmacy and Pharmacology Communications","issn_l":"1460-8081","issn":["1460-8081","2047-9948"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310311640","host_organization_name":"Royal Pharmaceutical Society","host_organization_lineage":["https://openalex.org/P4310311640"],"host_organization_lineage_names":["Royal Pharmaceutical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacy and Pharmacology Communications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2605484098","https://openalex.org/W2157544808","https://openalex.org/W2606781490","https://openalex.org/W2058552959","https://openalex.org/W2324541485","https://openalex.org/W2428194107","https://openalex.org/W2013790908","https://openalex.org/W1969966851","https://openalex.org/W2089064862","https://openalex.org/W2428179628"],"abstract_inverted_index":{"Six":[0],"new":[1,44],"ester":[2,69],"derivatives":[3,16,45,57],"of":[4,12,42,61,70],"\u03b3-(4-substituted":[5],"piperazinyl)-\u03b1-phenyl":[6],"propanol":[7,73],"were":[8,17,26],"prepared":[9],"by":[10],"esterification":[11,37],"the":[13,43,56,64,67,75],"\u03b3-piperazinyl":[14],"propanols.\r\n\r\n\r\n\r\nThe":[15],"methyl,":[18],"ethyl,":[19],"phenyl":[20],"and":[21,24],"benzyl":[22],"esters,":[23],"they":[25],"obtained":[27],"in":[28],"good":[29],"yields":[30],"using":[31,50],"a":[32],"solid-liquid":[33],"phase":[34],"transfer":[35],"catalysed":[36],"method.":[38],"The":[39],"nitrogen":[40],"content":[41],"was":[46],"also":[47],"determined.":[48],"Studies":[49],"isolated":[51],"guineapig":[52],"ileum":[53],"showed":[54,74],"that":[55],"possessed":[58],"varying":[59],"degrees":[60],"antispasmodic":[62,77],"activity.\r\n\r\n\r\n\r\nOf":[63],"compounds":[65],"evaluated,":[66],"ethyl":[68],"\u03b3-(4-benzyl":[71],"piperazin-1-yl)-\u03b1-phenyl":[72],"greatest":[76],"activity.":[78]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}