{"id":"https://openalex.org/W2007272731","doi":"https://doi.org/10.1210/jcem-69-6-1127","title":"Effects of Growth Hormone Therapy on Thyroid Function of Growth Hormone-Deficient Adults with and without Concomitant Thyroxine-Substituted Central Hypothyroidism*","display_name":"Effects of Growth Hormone Therapy on Thyroid Function of Growth Hormone-Deficient Adults with and without Concomitant Thyroxine-Substituted Central Hypothyroidism*","publication_year":1989,"publication_date":"1989-12-01","ids":{"openalex":"https://openalex.org/W2007272731","doi":"https://doi.org/10.1210/jcem-69-6-1127","mag":"2007272731","pmid":"https://pubmed.ncbi.nlm.nih.gov/2685007"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-69-6-1127","doi":"https://doi.org/10.1210/jcem-69-6-1127","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-69-6-1127","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090850055","display_name":"Jens Otto Lunde J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-7408-1526","observed_orcids":["https://orcid.org/0000-0001-7408-1526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. O. L. J\u00f8RGENSEN","raw_affiliation_strings":["Second University Clinic of Internal Medicine, Aarhus, Kommunehospital, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second University Clinic of Internal Medicine, Aarhus, Kommunehospital, Denmark","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. A. PEDERSEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S. A. PEDERSEN","raw_affiliation_strings":["Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus; University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus","University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus; University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2801942218"]},{"raw_affiliation_string":"Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]},{"raw_affiliation_string":"University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801942218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037544167","display_name":"Peter Thaysen Laurberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. LAURBERG","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113546485","display_name":"J. Weeke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. WEEKE","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111843675","display_name":"N E Skakkeb\u00e6k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2800392737","display_name":"Aarhus Municipality","ror":"https://ror.org/02wwbem66","country_code":"DK","type":"government","lineage":["https://openalex.org/I2800392737"]},{"id":"https://openalex.org/I2801942218","display_name":"Hvidovre Hospital","ror":"https://ror.org/00edrn755","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801942218","https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"N. E. SKAKKEB\u00c6K","raw_affiliation_strings":["Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus; University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus","University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus; University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2801942218"]},{"raw_affiliation_string":"Second University Clinic of Internal Medicine and Institute of Experimental Clinical Research, Aarhus Kommunehospital, and University of Aarhus Aarhus","institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2800392737"]},{"raw_affiliation_string":"University Department of Pediatrics, Hvidovre Hospital Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801942218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111785569","display_name":"J. S. Christiansen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. S. CHRISTIANSEN","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.6535,"has_fulltext":false,"cited_by_count":191,"citation_normalized_percentile":{"value":0.95052561,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"69","issue":"6","first_page":"1127","last_page":"1132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.9449999928474426},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.7839999794960022},{"id":"https://openalex.org/keywords/central-hypothyroidism","display_name":"central hypothyroidism","score":0.8960000276565552},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.7429999709129333},{"id":"https://openalex.org/keywords/thyroxine-binding-globulin","display_name":"thyroxine-binding globulin","score":0.5899999737739563},{"id":"https://openalex.org/keywords/reverse-t3","display_name":"reverse T3","score":0.7900000214576721},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.7860000133514404},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.7350000143051147},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.7450000047683716},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.5649999976158142},{"id":"https://openalex.org/keywords/resting-metabolic-rate","display_name":"resting metabolic rate","score":0.6510000228881836},{"id":"https://openalex.org/keywords/pituitary-derived-growth-hormone","display_name":"pituitary-derived growth hormone","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.878088653087616},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8601489067077637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8352965116500854},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6407186388969421},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5676546096801758},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5166447758674622},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.4814385771751404},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.45600900053977966},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4450478255748749},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014285","descriptor_name":"Triiodothyronine, Reverse","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-69-6-1127","doi":"https://doi.org/10.1210/jcem-69-6-1127","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-69-6-1127","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:2685007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2685007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1964802361","https://openalex.org/W1968861570","https://openalex.org/W1972868029","https://openalex.org/W1973566446","https://openalex.org/W1973989401","https://openalex.org/W1977319021","https://openalex.org/W1977506688","https://openalex.org/W1987355654","https://openalex.org/W1989749135","https://openalex.org/W1993351988","https://openalex.org/W1993358990","https://openalex.org/W1993434142","https://openalex.org/W1997150642","https://openalex.org/W1999211257","https://openalex.org/W2001118094","https://openalex.org/W2005892622","https://openalex.org/W2006807145","https://openalex.org/W2027638656","https://openalex.org/W2033503688","https://openalex.org/W2047997086","https://openalex.org/W2053936707","https://openalex.org/W2070390521","https://openalex.org/W2073453548","https://openalex.org/W2079183611","https://openalex.org/W2087425662","https://openalex.org/W2118032997","https://openalex.org/W2118853852","https://openalex.org/W2124524123","https://openalex.org/W2124821266","https://openalex.org/W2128790004","https://openalex.org/W2131223501","https://openalex.org/W2134581787","https://openalex.org/W2159060344","https://openalex.org/W2412466410","https://openalex.org/W2434172224","https://openalex.org/W2464206147","https://openalex.org/W2769849122","https://openalex.org/W2796303724","https://openalex.org/W4297888581"],"related_works":["https://openalex.org/W1971165631","https://openalex.org/W2247095170","https://openalex.org/W2320236986","https://openalex.org/W2131223501","https://openalex.org/W7005462777","https://openalex.org/W2021985236","https://openalex.org/W1987757088","https://openalex.org/W2094879337","https://openalex.org/W3092249498","https://openalex.org/W3011884038"],"abstract_inverted_index":{"Administration":[0],"of":[1,25,40,56,59,62,210,313,316,335],"human":[2,64],"GH":[3,39,65,120,152,245,284,320],"to":[4,23,318,323],"GH-deficient":[5,74],"patients":[6],"has":[7],"yielded":[8],"conflicting":[9],"results":[10],"concerning":[11],"its":[12],"impact":[13],"on":[14,70],"thyroid":[15,71],"function,":[16],"ranging":[17],"from":[18,297],"increased":[19],"resting":[20],"metabolic":[21],"rate":[22],"induction":[24],"hypothyroidism.":[26],"However,":[27],"most":[28],"studies":[29],"have":[30,36],"been":[31],"casuistic":[32],"or":[33,330],"uncontrolled":[34],"and":[35,78,200,237,293],"used":[37],"pituitary-derived":[38],"varying":[41],"purity,":[42],"often":[43],"contaminated":[44],"with":[45,309],"TSH.":[46],"Therefore,":[47],"we":[48],"conducted":[49],"a":[50,310],"double":[51],"blind,":[52],"placebo-controlled":[53],"cross-over":[54],"study":[55],"the":[57,101,207,300,333],"effect":[58],"4":[60],"months":[61],"biosynthetic":[63],"therapy":[66],"(Norditropin;":[67],"2":[68],"IU/m2.day)":[69],"function":[72],"in":[73,116,157,163,196,218,234,241,280,299,332],"adults":[75],"(8":[76],"females":[77],"14":[79],"males;":[80],"mean":[81],"+/-":[82,86,125,128,132,141,145,169,173,182,186,250,255,265,270],"SE":[83],"age,":[84],"23.8":[85],"1.2":[87],"yr).":[88],"One":[89],"group":[90,138,179,211,222,235,242,262],"(I)":[91],"was":[92,213,232,291],"euthyroid":[93],"without":[94],"T4":[95,106,111,199,317,337],"substitution":[96],"(n":[97,107],"=":[98,108],"13),":[99],"whereas":[100],"other":[102],"(group":[103],"II)":[104],"received":[105],"9).":[109],"Serum":[110,227,277,289],"(nanomoles":[112,160,229],"per":[113,161,230],"L)":[114,162,231],"decreased":[115,238,279],"both":[117,164,281],"groups":[118,165,282],"after":[119,244],"treatment":[121,153,246],"[group":[122,166,247],"I,":[123,167,248],"100":[124],"8":[126,133],"(mean":[127],"SE)":[129],"vs.":[130,143,171,184,253,268],"89":[131],"(P":[134,147,175,188,223],"less":[135,148,176,189,224,259,274],"than":[136,149,177,190,216,225,260,275],"0.01);":[137,261],"II,":[139,180,243,263],"145":[140],"18":[142],"115":[144],"10":[146],"0.05)].":[150,191],"Conversely,":[151],"caused":[154],"an":[155,219,325],"increase":[156],"serum":[158,197,203],"T3":[159,204],"1.9":[168,185],"0.1":[170,174,183,187],"2.0":[172],"0.1);":[178],"1.7":[181],"Similar":[192],"changes":[193],"were":[194],"seen":[195],"free":[198],"T3.":[201,319],"The":[202],"level":[205],"during":[206,283],"placebo":[208],"period":[209],"I":[212,236],"significantly":[214],"lower":[215],"that":[217,298],"age-matched":[220],"reference":[221,301],"0.02).":[226],"rT3":[228],"low":[233],"significantly,":[239],"as":[240],"0.26":[249],"0.02":[251,256,271],"(placebo)":[252,267],"0.20":[254],"(GH;":[257,272],"P":[258,273],"0.38":[264],"0.05":[266],"0.29":[269],"0.01)].":[276],"TSH":[278],"therapy,":[285],"though":[286],"not":[287,295],"significantly.":[288],"thyroglobulin":[290],"unaltered":[292],"did":[294],"differ":[296],"group.":[302],"In":[303],"conclusion,":[304],"our":[305],"data":[306],"are":[307],"consistent":[308],"GH-induced":[311],"enhancement":[312],"peripheral":[314,336],"deiodination":[315],"thus":[321],"seems":[322],"play":[324],"important":[326],"role,":[327],"either":[328],"directly":[329],"indirectly,":[331],"regulation":[334],"metabolism.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}