{"id":"https://openalex.org/W2007271767","doi":"https://doi.org/10.1021/tx800405v","title":"Products of Oxidative Stress Inhibit Aldehyde Oxidation and Reduction Pathways in Dopamine Catabolism Yielding Elevated Levels of a Reactive Intermediate","display_name":"Products of Oxidative Stress Inhibit Aldehyde Oxidation and Reduction Pathways in Dopamine Catabolism Yielding Elevated Levels of a Reactive Intermediate","publication_year":2009,"publication_date":"2009-04-23","ids":{"openalex":"https://openalex.org/W2007271767","doi":"https://doi.org/10.1021/tx800405v","mag":"2007271767","pmid":"https://pubmed.ncbi.nlm.nih.gov/19388687","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696154"},"language":"en","primary_location":{"id":"doi:10.1021/tx800405v","doi":"https://doi.org/10.1021/tx800405v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx800405v","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696154","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011730338","display_name":"Yunden Jinsmaa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunden Jinsmaa","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016391248","display_name":"Virginia R. Florang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virginia R. Florang","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073421190","display_name":"Jennifer Rees","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer N. Rees","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103156007","display_name":"David G. Anderson","orcid":"https://orcid.org/0000-0002-2831-6424","observed_orcids":["https://orcid.org/0000-0002-2831-6424"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Anderson","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070992833","display_name":"Stefan Strack","orcid":"https://orcid.org/0000-0002-6175-7280","observed_orcids":["https://orcid.org/0000-0002-6175-7280"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Strack","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040748951","display_name":"Jonathan A. Doorn","orcid":"https://orcid.org/0000-0001-9646-9871","observed_orcids":["https://orcid.org/0000-0001-9646-9871"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan A. Doorn","raw_affiliation_strings":["Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medicinal and Natural Products Chemistry, College of Pharmacy, and Department of Pharmacology, College of Medicine, The University of Iowa, 115 South Grand Avenue, Iowa City, Iowa 52242","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040748951"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":6.2405,"has_fulltext":false,"cited_by_count":110,"citation_normalized_percentile":{"value":0.96734545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"22","issue":"5","first_page":"835","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-catabolism","display_name":"dopamine catabolism","score":0.9660000205039978},{"id":"https://openalex.org/keywords/3-4-dihydroxyphenylacetaldehyde","display_name":"DOPAL","score":0.7689999938011169},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6510000228881836},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.9829999804496765},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":1.0},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase-inhibition","display_name":"aldehyde dehydrogenase inhibition","score":0.9279999732971191},{"id":"https://openalex.org/keywords/aldose-reductase-inhibition","display_name":"aldose reductase inhibition","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9369999766349792},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.753000020980835},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.6700000166893005},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.5600000023841858},{"id":"https://openalex.org/keywords/monoamine-oxidase","display_name":"monoamine oxidase","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.8144838809967041},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.8008843064308167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6994735598564148},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6262476444244385},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5869778990745544},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.536354660987854},{"id":"https://openalex.org/C2779308327","wikidata":"https://www.wikidata.org/wiki/Q229982","display_name":"4-Hydroxynonenal","level":4,"score":0.5166268944740295},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4774811267852783},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.44036585092544556},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2549900412559509},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2526015043258667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17576536536216736}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010626","descriptor_name":"Phenylethyl Alcohol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/tx800405v","doi":"https://doi.org/10.1021/tx800405v","is_oa":false,"landing_page_url":"https://doi.org/10.1021/tx800405v","pdf_url":null,"source":{"id":"https://openalex.org/S152840809","display_name":"Chemical Research in Toxicology","issn_l":"0893-228X","issn":["0893-228X","1520-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Research in Toxicology","raw_type":"journal-article"},{"id":"pmid:19388687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19388687","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical research in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2696154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2696154","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2696154","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Res Toxicol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5094337163","display_name":"Protein Modification by 3,4-Dihydroxyphenylacetaldehyde","funder_award_id":"K22ES012982","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5379931664","display_name":"Predoctoral Training Program in Biotechnology","funder_award_id":"T32GM008365","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G758959686","display_name":"Organochlorine-Mediated Generation of a Dopamine Derived Neurotoxin","funder_award_id":"R01ES015507","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000339672","display_name":"Environmental Health Sciences Research Center","funder_award_id":"P30ES005605","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W88545136","https://openalex.org/W196852912","https://openalex.org/W1526677948","https://openalex.org/W1919287714","https://openalex.org/W1972381933","https://openalex.org/W1975267409","https://openalex.org/W1975669691","https://openalex.org/W1980234111","https://openalex.org/W1983159631","https://openalex.org/W1985670077","https://openalex.org/W1992998321","https://openalex.org/W1994043090","https://openalex.org/W1996805139","https://openalex.org/W2007635795","https://openalex.org/W2008158988","https://openalex.org/W2009351391","https://openalex.org/W2012609836","https://openalex.org/W2013734734","https://openalex.org/W2016756266","https://openalex.org/W2017621114","https://openalex.org/W2031828473","https://openalex.org/W2037417959","https://openalex.org/W2041040996","https://openalex.org/W2044271936","https://openalex.org/W2048897966","https://openalex.org/W2054894609","https://openalex.org/W2057522312","https://openalex.org/W2063018977","https://openalex.org/W2064344777","https://openalex.org/W2065188886","https://openalex.org/W2068509668","https://openalex.org/W2070703124","https://openalex.org/W2071147504","https://openalex.org/W2077697853","https://openalex.org/W2089518139","https://openalex.org/W2096557101","https://openalex.org/W2107584701","https://openalex.org/W2109379634","https://openalex.org/W2118389697","https://openalex.org/W2120412340","https://openalex.org/W2122742102","https://openalex.org/W2163203292","https://openalex.org/W2164853857","https://openalex.org/W2211987820"],"related_works":["https://openalex.org/W2016756266","https://openalex.org/W1972381933","https://openalex.org/W1988131381","https://openalex.org/W4206677786","https://openalex.org/W2068509668","https://openalex.org/W1964832419","https://openalex.org/W2738414744","https://openalex.org/W173229966","https://openalex.org/W2070703124","https://openalex.org/W3159623188"],"abstract_inverted_index":{"Dopamine":[0],"(DA)":[1],"has":[2],"been":[3],"implicated":[4],"as":[5,14,143,291],"an":[6,234],"endogenous":[7,280],"neurotoxin":[8,281],"to":[9,40,47,66,81,86,232,288],"explain":[10],"the":[11,93,128,152,225,260,268,279],"selective":[12,289],"neurodegeneration":[13,290],"observed":[15,223],"for":[16,146,224],"Parkinson's":[17],"disease":[18],"(PD).":[19],"In":[20,202],"addition,":[21],"oxidative":[22,261,286],"stress":[23,262,287],"and":[24,58,91,102,156,165,185,192,265],"lipid":[25,95,118],"peroxidation":[26,96,119],"are":[27],"hypothesized":[28],"culprits":[29],"in":[30,151,188,216,293],"PD":[31],"pathogenesis.":[32],"DA":[33,87,90,147,273],"undergoes":[34],"catabolism":[35,274],"by":[36,162],"monoamine":[37],"oxidase":[38],"(MAO)":[39],"3,4-dihydroxyphenylacetaldehyde":[41],"(DOPAL),":[42],"which":[43,283],"is":[44,116],"further":[45],"oxidized":[46],"3,4-dihydroxyphenylacetic":[48],"acid":[49],"(DOPAC)":[50],"via":[51,69,109],"aldehyde":[52,71,130,269],"dehydrogenase":[53],"(ALDH).":[54],"As":[55],"a":[56,144,213],"minor":[57],"compensatory":[59],"metabolic":[60],"pathway,":[61],"DOPAL":[62,80,107,122,196],"can":[63],"be":[64,82,233],"reduced":[65,189],"3,4-dihydroxyphenylethanol":[67],"(DOPET)":[68],"cytosolic":[70,240],"or":[72],"aldose":[73],"reductase":[74,251],"(AR).":[75],"Previous":[76],"studies":[77],"have":[78],"found":[79,168,244],"significantly":[83],"more":[84],"toxic":[85,129],"cells":[88,140,179,203,226],"than":[89],"that":[92,98,117,169,207,245,259],"major":[94],"products,":[97],"is,":[99],"4-hydroxynonenal":[100],"(4HNE)":[101],"malondialdehyde":[103],"(MDA),":[104],"potently":[105],"inhibit":[106,121,267],"oxidation":[108],"ALDH.":[110,201],"The":[111],"hypothesis":[112],"of":[113,127,154,178,183,195,200,236,272,278],"this":[114,134],"work":[115],"products":[120,263],"oxidation,":[123],"yielding":[124,275],"aberrant":[125],"levels":[126,277],"intermediate.":[131],"To":[132],"test":[133],"hypothesis,":[135],"nerve":[136],"growth":[137],"factor-differentiated":[138],"PC6-3":[139],"were":[141],"used":[142],"model":[145],"neurons.":[148],"Cell":[149],"viability":[150],"presence":[153],"4HNE":[155,173,184,206,249,264],"MDA":[157,186,231,246,266],"(2-100":[158],"microM)":[159],"was":[160,167,212,221,243],"measured":[161],"MTT":[163],"assay,":[164],"it":[166,242],"only":[170],"100":[171],"microM":[172],"exhibited":[174,208],"significant":[175,193,214],"cytotoxicity.":[176],"Treatment":[177],"with":[180,205,228],"varying":[181],"concentrations":[182],"resulted":[187],"DOPAC":[190],"production":[191],"elevation":[194],"levels,":[197],"suggesting":[198,230],"inhibition":[199],"treated":[204,227],"elevated":[209,219,276],"DOPAL,":[210,254,282],"there":[211],"increase":[215],"DOPET.":[217],"However,":[218],"DOPET":[220],"not":[222,248],"MDA,":[229],"inhibitor":[235],"AR.":[237],"Using":[238],"isolated":[239],"AR,":[241],"but":[247],"inhibited":[250],"activity":[252],"toward":[253],"surprisingly.":[255],"These":[256],"data":[257],"demonstrate":[258],"biotransformation":[270],"step":[271],"may":[284],"link":[285],"seen":[292],"PD.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}