{"id":"https://openalex.org/W2007270929","doi":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","title":"Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection","display_name":"Optimal duration of therapy combining ranitidine bismuth citrate with clarithromycin and metronidazole in the eradication of Helicobacter pylori infection","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2007270929","doi":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","mag":"2007270929","pmid":"https://pubmed.ncbi.nlm.nih.gov/9892878"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2036.1999.00436.x","doi":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2036.1999.00436.x","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2036.1999.00436.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111825380","display_name":"SAVARINO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"SAVARINO","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026825925","display_name":"Patrizia Zentilin","orcid":"https://orcid.org/0000-0002-9235-6308","observed_orcids":["https://orcid.org/0000-0002-9235-6308"]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"ZENTILIN","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097427547","display_name":"Bisso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"BISSO","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097427548","display_name":"Pivari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"PIVARI","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097427549","display_name":"Bilardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"BILARDI","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088437960","display_name":"Biagini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"BIAGINI","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112175912","display_name":"M.R. Mele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MELE","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102350025","display_name":"Mansi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"MANSI","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097855886","display_name":"TERMINI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"TERMINI","raw_affiliation_strings":["Istituto di Medicina Interna e Geriatria, Universita\u0300 di Palermo, Italy","Istituto di Medicina Interna e Geriatria, Universit\u00e0 di Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna e Geriatria, Universita\u0300 di Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Istituto di Medicina Interna e Geriatria, Universit\u00e0 di Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049535091","display_name":"Vigneri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"VIGNERI","raw_affiliation_strings":["Istituto di Medicina Interna e Geriatria, Universita\u0300 di Palermo, Italy","Istituto di Medicina Interna e Geriatria, Universit\u00e0 di Palermo, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Medicina Interna e Geriatria, Universita\u0300 di Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]},{"raw_affiliation_string":"Istituto di Medicina Interna e Geriatria, Universit\u00e0 di Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5097991874","display_name":"CELLE.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"CELLE","raw_affiliation_strings":["Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialita\u0300 Mediche, Cattedra di Gastroenterologia, Universita\u0300 di Genova, Italy,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Dipartimento di Medicina Interna e Specialit\u00e0 Mediche, Cattedra di Gastroenterologia, Universit\u00e0 di Genova, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111825380"],"corresponding_institution_ids":["https://openalex.org/I83816512"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":4.559,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.944009,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"1","first_page":"43","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori-eradication","display_name":"Helicobacter pylori eradication","score":0.9629999995231628},{"id":"https://openalex.org/keywords/ranitidine-bismuth-citrate","display_name":"ranitidine bismuth citrate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clarithromycin","display_name":"clarithromycin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/metronidazole","display_name":"metronidazole","score":1.0},{"id":"https://openalex.org/keywords/triple-therapy","display_name":"triple therapy","score":0.9649999737739563},{"id":"https://openalex.org/keywords/treatment-duration","display_name":"treatment duration","score":0.9580000042915344},{"id":"https://openalex.org/keywords/13c-urea-breath-test","display_name":"13C-urea breath test","score":0.8640000224113464},{"id":"https://openalex.org/keywords/dyspepsia","display_name":"dyspepsia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/eradication-rate","display_name":"eradication rate","score":0.5730000138282776},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6460000276565552},{"id":"https://openalex.org/keywords/rapid-urease-test","display_name":"rapid urease test","score":0.5049999952316284},{"id":"https://openalex.org/keywords/histology","display_name":"histology","score":0.7170000076293945},{"id":"https://openalex.org/keywords/intention-to-treat-analysis","display_name":"intention-to-treat analysis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/per-protocol-analysis","display_name":"per-protocol analysis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8513031005859375},{"id":"https://openalex.org/C2776962512","wikidata":"https://www.wikidata.org/wiki/Q118551","display_name":"Clarithromycin","level":3,"score":0.829013466835022},{"id":"https://openalex.org/C2777396551","wikidata":"https://www.wikidata.org/wiki/Q169569","display_name":"Metronidazole","level":3,"score":0.8065775632858276},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7414056658744812},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.7226040363311768},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6570649743080139},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6396296620368958},{"id":"https://openalex.org/C2777445857","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine","level":2,"score":0.5710533261299133},{"id":"https://openalex.org/C2910259375","wikidata":"https://www.wikidata.org/wiki/Q423037","display_name":"Ranitidine Hydrochloride","level":3,"score":0.5605303645133972},{"id":"https://openalex.org/C2775981797","wikidata":"https://www.wikidata.org/wiki/Q638366","display_name":"Breath test","level":3,"score":0.5460028052330017},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.4939945340156555},{"id":"https://openalex.org/C2777172195","wikidata":"https://www.wikidata.org/wiki/Q186604","display_name":"Urea breath test","level":4,"score":0.4866410195827484},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.41310393810272217},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.35375189781188965},{"id":"https://openalex.org/C2908868296","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori infection","level":3,"score":0.2240019142627716},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.06037303805351257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001729","descriptor_name":"Bismuth","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001944","descriptor_name":"Breath Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006635","descriptor_name":"Histamine H2 Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008795","descriptor_name":"Metronidazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011899","descriptor_name":"Ranitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017291","descriptor_name":"Clarithromycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1046/j.1365-2036.1999.00436.x","doi":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2036.1999.00436.x","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmid:9892878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9892878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Clinical Trial"},{"id":"pmh:oai:iris.unige.it:11567/284119","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/284119","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1046/j.1365-2036.1999.00436.x","doi":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","is_oa":true,"landing_page_url":"https://doi.org/10.1046/j.1365-2036.1999.00436.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2036.1999.00436.x","source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007270929.pdf","grobid_xml":"https://content.openalex.org/works/W2007270929.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1590686299","https://openalex.org/W1965116666","https://openalex.org/W1966698352","https://openalex.org/W1971109200","https://openalex.org/W1975143885","https://openalex.org/W1987827439","https://openalex.org/W2008997355","https://openalex.org/W2047542337","https://openalex.org/W2056514328","https://openalex.org/W2061227902","https://openalex.org/W2065334333","https://openalex.org/W2088130383","https://openalex.org/W2091181260","https://openalex.org/W2123561535","https://openalex.org/W2123848597","https://openalex.org/W2132649170","https://openalex.org/W2133799527","https://openalex.org/W2138438059","https://openalex.org/W2141274436","https://openalex.org/W2146944411","https://openalex.org/W2149167650","https://openalex.org/W2153323409","https://openalex.org/W2412635196","https://openalex.org/W3112650786","https://openalex.org/W4237403611","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3151074172","https://openalex.org/W1966698352","https://openalex.org/W2023496876","https://openalex.org/W1971109200","https://openalex.org/W2084136229","https://openalex.org/W2090351739","https://openalex.org/W1987455468","https://openalex.org/W119819653","https://openalex.org/W1990907281","https://openalex.org/W2218293826"],"abstract_inverted_index":{"BACKGROUND:":[0],"Ranitidine":[1],"bismuth":[2],"citrate":[3],"(RBC)":[4],"co-prescribed":[5],"with":[6],"clarithromycin":[7,61],"and":[8,65,76,90,128,147,160,162,168,174,189,201,204,207,214,229,235,250,277,291],"metronidazole":[9,66],"for":[10,22,43,70,136,303],"1":[11,296],"week":[12,297],"has":[13],"been":[14],"shown":[15],"to":[16,240,271],"be":[17],"an":[18],"effective":[19],"eradicating":[20],"regimen":[21],"Helicobacter":[23],"pylori.":[24],"AIM:":[25],"To":[26],"determine":[27],"the":[28,85,94,103,117,134,141,145,150,163,171,199,202,205,208,232,248,253,265,299],"optimal":[29,300],"duration":[30,266],"of":[31,37,88,105,119,133,231,267,280,294,306],"this":[32,44,304],"regimen.":[33],"METHODS:":[34],"A":[35],"series":[36],"165":[38],"dyspeptic":[39],"patients":[40,130],"were":[41,50,125,157,224],"recruited":[42],"randomized,":[45],"open,":[46],"parallel-group":[47],"study.":[48],"They":[49,238],"subdivided":[51],"into":[52],"three":[53,71,123,251],"groups":[54],"receiving":[55],"RBC":[56,310],"400":[57],"mg":[58,63,68],"b.d.":[59,64,69],"plus":[60,311],"250":[62],"500":[67],"different":[72],"periods":[73,216],"(4,":[74],"7":[75,290],"10":[77,292],"days).":[78],"H.":[79,281],"pylori":[80,282],"infection":[81],"was":[82,99,180,257],"assessed":[83],"by":[84],"concomitant":[86],"positivity":[87],"CLO-test":[89],"histology":[91],"performed":[92,111],"at":[93,112],"pre-entry":[95],"endoscopy.":[96],"The":[97,122,212],"bacterium":[98],"considered":[100],"eradicated":[101],"on":[102,187,194,309],"basis":[104],"a":[106,181,275],"negative":[107],"13C-urea":[108],"breath":[109],"test":[110],"least":[113],"28":[114],"days":[115,273,293],"after":[116],"completion":[118],"treatment.":[120],"RESULTS:":[121],"subgroups":[124],"well":[126],"matched":[127],"16":[129],"dropped":[131],"out":[132],"study":[135],"many":[137],"reasons":[138],"(six":[139],"in":[140,144,149,170,226,243,247,252],"4-day,":[142,172],"five":[143,148],"7-day":[146,173,203,213,249],"10-day":[151,175,209,215,236,254],"treatment":[152,176,242],"regimens).":[153],"Intention-to-treat":[154],"cure":[155],"rates":[156,165],"60%,":[158],"84%":[159],"85%,":[161],"per-protocol":[164],"67%,":[166],"92%":[167],"94%":[169],"regimens,":[177],"respectively.":[178,211],"There":[179,256],"significant":[182],"difference,":[183],"P":[184,190],"=":[185,191],"0.003-0.006":[186],"intention-to-treat":[188],"0.001-0.":[192],"002":[193],"per":[195],"protocol":[196],"analysis":[197],"between":[198,289],"4-day":[200,206],"periods,":[210],"did":[217],"not":[218],"differ":[219],"from":[220],"each":[221],"other.":[222],"Side-effects":[223],"reported":[225],"9%,":[227],"14%":[228],"20%":[230],"4-,":[233],"7-":[234],"regimens.":[237],"led":[239],"stopping":[241],"four":[244],"cases":[245],"(one":[246],"period).":[255],"no":[258,287],"statistical":[259],"difference":[260,288],"among":[261],"them.":[262],"CONCLUSIONS:":[263],"Reducing":[264],"RBC-based":[268],"triple":[269],"therapy":[270],"4":[272],"provides":[274],"low":[276],"unacceptable":[278],"rate":[279],"eradication.":[283],"As":[284],"there":[285],"is":[286],"treatment,":[295,307],"represents":[298],"time":[301],"period":[302],"kind":[305],"based":[308],"two":[312],"antibiotics.":[313]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
