{"id":"https://openalex.org/W2007259634","doi":"https://doi.org/10.1016/j.tetlet.2010.09.130","title":"Synthesis of new cytotoxic E-ring modified camptothecins","display_name":"Synthesis of new cytotoxic E-ring modified camptothecins","publication_year":2010,"publication_date":"2010-10-09","ids":{"openalex":"https://openalex.org/W2007259634","doi":"https://doi.org/10.1016/j.tetlet.2010.09.130","mag":"2007259634"},"language":"en","primary_location":{"id":"doi:10.1016/j.tetlet.2010.09.130","doi":"https://doi.org/10.1016/j.tetlet.2010.09.130","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2010.09.130","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056549241","display_name":"Salvatore Cananzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Cananzi","raw_affiliation_strings":["Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071576099","display_name":"Sabrina Dallavalle","orcid":"https://orcid.org/0000-0002-8813-8922","observed_orcids":["https://orcid.org/0000-0002-8813-8922"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Sabrina Dallavalle","raw_affiliation_strings":["Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005000224","display_name":"Alberto Bargiotti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Bargiotti","raw_affiliation_strings":["Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017931392","display_name":"Lucio Merlini","orcid":"https://orcid.org/0000-0002-6613-9422","observed_orcids":["https://orcid.org/0000-0002-6613-9422"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucio Merlini","raw_affiliation_strings":["Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universit\u00e0 di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Dipartimento di Scienze Molecolari Agroalimentari, Universita di Milano, Via Celoria 2, 20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067068751","display_name":"Roberto Artali","orcid":"https://orcid.org/0000-0002-6289-5546","observed_orcids":["https://orcid.org/0000-0002-6289-5546"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto Artali","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche \u2018P. Pratesi\u2019, Universit\u00e0 di Milano, Via Mangiagalli 25, I-20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche \u2018P. Pratesi\u2019, Universit\u00e0 di Milano, Via Mangiagalli 25, I-20133 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004757300","display_name":"Giovanni Luca Beretta","orcid":"https://orcid.org/0000-0002-5961-4109","observed_orcids":["https://orcid.org/0000-0002-5961-4109"]},"institutions":[{"id":"https://openalex.org/I4210156707","display_name":"Fondazione IRCCS Istituto Nazionale dei Tumori","ror":"https://ror.org/05dwj7825","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210156707"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Luca Beretta","raw_affiliation_strings":["Unit\u00e0 di Chemioterapia e Farmacologia Antitumorale Preclinica, Dipartimento di Oncologia Sperimentale e Laboratori, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e0 di Chemioterapia e Farmacologia Antitumorale Preclinica, Dipartimento di Oncologia Sperimentale e Laboratori, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milano, Italy","institution_ids":["https://openalex.org/I4210156707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071576099"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":0.4248,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55240367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"51","issue":"50","first_page":"6489","last_page":"6492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13105","display_name":"Synthesis and pharmacology of benzodiazepine derivatives","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13221","display_name":"Biological Activity of Diterpenoids and Biflavonoids","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camptothecin-analogs","display_name":"camptothecin analogues","score":0.8920000195503235},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9010000228881836},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.7390000224113464},{"id":"https://openalex.org/keywords/h460-cells","display_name":"H460 cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6290000081062317},{"id":"https://openalex.org/keywords/total-synthesis","display_name":"total synthesis","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9639524817466736},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.8841234445571899},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.6975449323654175},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6948741674423218},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6299689412117004},{"id":"https://openalex.org/C2776612806","wikidata":"https://www.wikidata.org/wiki/Q59078","display_name":"Lactone","level":2,"score":0.6178141832351685},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38203293085098267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22986358404159546},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.16965362429618835},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.114938884973526}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.tetlet.2010.09.130","doi":"https://doi.org/10.1016/j.tetlet.2010.09.130","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tetlet.2010.09.130","pdf_url":null,"source":{"id":"https://openalex.org/S133942674","display_name":"Tetrahedron Letters","issn_l":"0040-4039","issn":["0040-4039","1873-3581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1536538430","https://openalex.org/W1871475547","https://openalex.org/W1979194751","https://openalex.org/W1981987977","https://openalex.org/W1997361520","https://openalex.org/W1999567947","https://openalex.org/W2000518530","https://openalex.org/W2018185888","https://openalex.org/W2018611782","https://openalex.org/W2032336908","https://openalex.org/W2045116568","https://openalex.org/W2056249358","https://openalex.org/W2058504183","https://openalex.org/W2070534090","https://openalex.org/W2074325268","https://openalex.org/W2086353181","https://openalex.org/W2101878691","https://openalex.org/W2117660512","https://openalex.org/W2123646979","https://openalex.org/W2177353358","https://openalex.org/W2950524520","https://openalex.org/W2952750132"],"related_works":["https://openalex.org/W1986303714","https://openalex.org/W2006979253","https://openalex.org/W2023880636","https://openalex.org/W2058504183","https://openalex.org/W2008169312","https://openalex.org/W1990878852","https://openalex.org/W1987398643","https://openalex.org/W2950111368","https://openalex.org/W2950826864","https://openalex.org/W2327782276"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}