{"id":"https://openalex.org/W2007246397","doi":"https://doi.org/10.1021/jm00189a001","title":"Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly","display_name":"Conformational analysis of podophyllotoxin and its congeners. Structure-activity relationship in microtubule assembly","publication_year":1979,"publication_date":"1979-03-01","ids":{"openalex":"https://openalex.org/W2007246397","doi":"https://doi.org/10.1021/jm00189a001","mag":"2007246397","pmid":"https://pubmed.ncbi.nlm.nih.gov/423203"},"language":"en","primary_location":{"id":"doi:10.1021/jm00189a001","doi":"https://doi.org/10.1021/jm00189a001","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00189a001","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039138618","display_name":"C. Fred Brewer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Fred Brewer","raw_affiliation_strings":["Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112775965","display_name":"John D. Loike","orcid":"https://orcid.org/0000-0002-9769-9772","observed_orcids":["https://orcid.org/0000-0002-9769-9772"]},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John D. Loike","raw_affiliation_strings":["Yeshiva University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yeshiva University","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susan B. Horwitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan B. Horwitz","raw_affiliation_strings":["Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072038665","display_name":"Himan Sternlicht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himan Sternlicht","raw_affiliation_strings":["[Brookhaven National Laboratory]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"[Brookhaven National Laboratory]","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111736642","display_name":"Walter J. Gensler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter J. Gensler","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1696,"has_fulltext":false,"cited_by_count":113,"citation_normalized_percentile":{"value":0.74398201,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"3","first_page":"215","last_page":"221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.9272000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/podophyllotoxin","display_name":"podophyllotoxin","score":1.0},{"id":"https://openalex.org/keywords/conformational-analysis","display_name":"conformational analysis","score":0.7860000133514404},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.968999981880188},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.9660000205039978},{"id":"https://openalex.org/keywords/antimitotic-agents","display_name":"antimitotic agents","score":0.777999997138977},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6152535676956177},{"id":"https://openalex.org/C2778143360","wikidata":"https://www.wikidata.org/wiki/Q421193","display_name":"Podophyllotoxin","level":2,"score":0.5369225740432739},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.49521175026893616},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.484578013420105},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.4733082056045532},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3605844974517822},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.32394397258758545},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.255296528339386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22330361604690552},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.11272841691970825},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm00189a001","doi":"https://doi.org/10.1021/jm00189a001","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm00189a001","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:423203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/423203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1604736734","https://openalex.org/W2751385922","https://openalex.org/W2124248613","https://openalex.org/W2012232448","https://openalex.org/W2516683459","https://openalex.org/W2326121590","https://openalex.org/W2090503116","https://openalex.org/W2331851562","https://openalex.org/W2051235129","https://openalex.org/W2240804638"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVArticleNEXTConformational":[3],"analysis":[4],"of":[5,62,97,123],"podophyllotoxin":[6],"and":[7,25,72,77,106,150,167,183,185],"its":[8],"congeners.":[9],"Structure-activity":[10],"relationship":[11],"in":[12],"microtubule":[13],"assemblyC.":[14],"Fred":[15],"Brewer,":[16],"John":[17],"D.":[18],"Loike,":[19],"Susan":[20],"B.":[21],"Horwitz,":[22],"Himan":[23],"Sternlicht,":[24],"Walter":[26],"J.":[27,30],"GenslerCite":[28],"this:":[29],"Med.":[31],"Chem.":[32],"1979,":[33],"22,":[34],"3,":[35],"215\u2013221Publication":[36],"Date":[37],"(Print):March":[38],"1,":[39],"1979Publication":[40],"History":[41],"Published":[42],"online1":[43],"May":[44],"2002Published":[45],"inissue":[46],"1":[47],"March":[48],"1979https://pubs.acs.org/doi/10.1021/jm00189a001https://doi.org/10.1021/jm00189a001research-articleACS":[49],"PublicationsRequest":[50],"reuse":[51],"permissionsArticle":[52],"Views439Altmetric-Citations94LEARN":[53],"ABOUT":[54],"THESE":[55],"METRICSArticle":[56],"Views":[57],"are":[58,81,94],"the":[59,90,95,124,135,148,151,156,163,169],"COUNTER-compliant":[60],"sum":[61],"full":[63],"text":[64],"article":[65,129],"downloads":[66],"since":[67],"November":[68],"2008":[69],"(both":[70],"PDF":[71],"HTML)":[73],"across":[74],"all":[75],"institutions":[76],"individuals.":[78],"These":[79],"metrics":[80],"regularly":[82],"updated":[83,107],"to":[84,89],"reflect":[85],"usage":[86],"leading":[87],"up":[88],"last":[91],"few":[92],"days.Citations":[93],"number":[96],"other":[98],"articles":[99],"citing":[100],"this":[101],"article,":[102],"calculated":[103],"by":[104],"Crossref":[105,113],"daily.":[108],"Find":[109,159],"more":[110,160],"information":[111,161],"about":[112,147],"citation":[114],"counts.The":[115],"Altmetric":[116,164],"Attention":[117,165],"Score":[118,166],"is":[119,171],"a":[120,127,140],"quantitative":[121],"measure":[122],"attention":[125],"that":[126],"research":[128],"has":[130],"received":[131],"online.":[132],"Clicking":[133],"on":[134,162],"donut":[136],"icon":[137],"will":[138],"load":[139],"page":[141],"at":[142],"altmetric.com":[143],"with":[144,179],"additional":[145],"details":[146],"score":[149,170],"social":[152],"media":[153],"presence":[154],"for":[155],"given":[157],"article.":[158],"how":[168],"calculated.":[172],"Share":[173,188],"Add":[174],"toView":[175],"InAdd":[176],"Full":[177],"Text":[178],"ReferenceAdd":[180],"Description":[181],"ExportRISCitationCitation":[182],"abstractCitation":[184],"referencesMore":[186],"Options":[187],"onFacebookTwitterWechatLinked":[189],"InRedditEmail":[190],"Other":[191],"access":[192],"optionsGet":[193],"e-Alertsclose":[194],"Get":[195],"e-Alerts":[196]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
