{"id":"https://openalex.org/W2007245358","doi":"https://doi.org/10.1016/0168-9525(89)90040-1","title":"Platelet-derived growth factor: Three isoforms and two receptor types","display_name":"Platelet-derived growth factor: Three isoforms and two receptor types","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W2007245358","doi":"https://doi.org/10.1016/0168-9525(89)90040-1","mag":"2007245358","pmid":"https://pubmed.ncbi.nlm.nih.gov/2543106"},"language":"en","primary_location":{"id":"doi:10.1016/0168-9525(89)90040-1","doi":"https://doi.org/10.1016/0168-9525(89)90040-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-9525(89)90040-1","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2007245358"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084535456","display_name":"Carl\u2010Henrik Heldin","orcid":"https://orcid.org/0000-0002-9508-896X","observed_orcids":["https://orcid.org/0000-0002-9508-896X"]},"institutions":[{"id":"https://openalex.org/I4210133710","display_name":"Ludwig Cancer Research","ror":"https://ror.org/03gvptg28","country_code":"SE","type":"nonprofit","lineage":["https://openalex.org/I4210133710","https://openalex.org/I4210150094"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carl-Henrik Heldin","raw_affiliation_strings":["C-H. Heldin is in the Ludwig Institute for Cancer Research,Biomedical Center, Box 595, S-751 23, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C-H. Heldin is in the Ludwig Institute for Cancer Research,Biomedical Center, Box 595, S-751 23, Uppsala, Sweden","institution_ids":["https://openalex.org/I4210133710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090354704","display_name":"Bengt Westermark","orcid":"https://orcid.org/0000-0001-7153-5545","observed_orcids":["https://orcid.org/0000-0001-7153-5545"]},"institutions":[{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Westermark","raw_affiliation_strings":["B. Westermark is in the Department of Pathology, UniversityHospital, S-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"B. Westermark is in the Department of Pathology, UniversityHospital, S-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":2.3034,"has_fulltext":false,"cited_by_count":176,"citation_normalized_percentile":{"value":0.8935611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4","first_page":"108","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.3508000075817108,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.16130000352859497,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.11890000104904175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":1.0},{"id":"https://openalex.org/keywords/pdgf-isoforms","display_name":"PDGF isoforms","score":0.9929999709129333},{"id":"https://openalex.org/keywords/pdgf-receptor","display_name":"PDGF receptor","score":0.9750000238418579},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/receptor-heterodimers","display_name":"receptor heterodimers","score":0.6470000147819519},{"id":"https://openalex.org/keywords/receptor-homodimers","display_name":"receptor homodimers","score":0.6990000009536743},{"id":"https://openalex.org/keywords/receptor-expression","display_name":"receptor expression","score":0.4090000092983246},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.795143723487854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7908991575241089},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7207604050636292},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6942670345306396},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.5961734652519226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5791361331939697},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.485460102558136},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.4736974239349365},{"id":"https://openalex.org/C21936154","wikidata":"https://www.wikidata.org/wiki/Q14911786","display_name":"Insulin-like growth factor 2 receptor","level":5,"score":0.45990654826164246},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.44420143961906433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35442763566970825},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.21998581290245056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12261351943016052}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017479","descriptor_name":"Receptors, Platelet-Derived Growth Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0168-9525(89)90040-1","doi":"https://doi.org/10.1016/0168-9525(89)90040-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0168-9525(89)90040-1","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},{"id":"pmid:2543106","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2543106","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in genetics : TIG","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W263572369","https://openalex.org/W1419200150","https://openalex.org/W1494589518","https://openalex.org/W1551210345","https://openalex.org/W1553223526","https://openalex.org/W1570937314","https://openalex.org/W1571288613","https://openalex.org/W1595723592","https://openalex.org/W1703816965","https://openalex.org/W1801102136","https://openalex.org/W1839524200","https://openalex.org/W1964822816","https://openalex.org/W1974967725","https://openalex.org/W1979286083","https://openalex.org/W1982020713","https://openalex.org/W1991466542","https://openalex.org/W2011957331","https://openalex.org/W2023441605","https://openalex.org/W2025529909","https://openalex.org/W2040470809","https://openalex.org/W2045389909","https://openalex.org/W2046733107","https://openalex.org/W2050601632","https://openalex.org/W2056557043","https://openalex.org/W2072105764","https://openalex.org/W2073478078","https://openalex.org/W2086555107","https://openalex.org/W2093101342","https://openalex.org/W2128781299","https://openalex.org/W2148371225","https://openalex.org/W2150268629","https://openalex.org/W2366627350"],"related_works":["https://openalex.org/W2339411017","https://openalex.org/W2368817160","https://openalex.org/W1973875365","https://openalex.org/W2136390877","https://openalex.org/W2091960256","https://openalex.org/W2011842276","https://openalex.org/W2017999418","https://openalex.org/W2057866456","https://openalex.org/W2059051865","https://openalex.org/W94751027"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}