{"id":"https://openalex.org/W2007242914","doi":"https://doi.org/10.1097/00005344-199010000-00002","title":"High-Dose Iron-Chelator Therapy During Reperfusion with Deferoxamine-Hydroxyethyl Starch Conjugate Fails to Reduce Canine Infarct Size","display_name":"High-Dose Iron-Chelator Therapy During Reperfusion with Deferoxamine-Hydroxyethyl Starch Conjugate Fails to Reduce Canine Infarct Size","publication_year":1990,"publication_date":"1990-10-01","ids":{"openalex":"https://openalex.org/W2007242914","doi":"https://doi.org/10.1097/00005344-199010000-00002","mag":"2007242914","pmid":"https://pubmed.ncbi.nlm.nih.gov/1706792"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199010000-00002","doi":"https://doi.org/10.1097/00005344-199010000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199010000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014524067","display_name":"Edward Joseph Lesnefsky","orcid":"https://orcid.org/0000-0002-9672-7065","observed_orcids":["https://orcid.org/0000-0002-9672-7065"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Lesnefsky","raw_affiliation_strings":["Division of Cardiology, University of Colorado Health Sciences Center, Denver","Colorado","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"Colorado","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113849089","display_name":"Bo E. Hedlund","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163324","display_name":"Biomedical Frontiers (United States)","ror":"https://ror.org/02yx0gd46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo E. Hedlund","raw_affiliation_strings":["Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","Colorado","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]},{"raw_affiliation_string":"and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","institution_ids":["https://openalex.org/I4210163324"]},{"raw_affiliation_string":"Colorado","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057274205","display_name":"Philip E. Hallaway","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163324","display_name":"Biomedical Frontiers (United States)","ror":"https://ror.org/02yx0gd46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip E. Hallaway","raw_affiliation_strings":["Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","Colorado","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]},{"raw_affiliation_string":"and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","institution_ids":["https://openalex.org/I4210163324"]},{"raw_affiliation_string":"Colorado","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064238953","display_name":"Lawrence D. Horwitz","orcid":"https://orcid.org/0000-0001-5328-6020","observed_orcids":["https://orcid.org/0000-0001-5328-6020"]},"institutions":[{"id":"https://openalex.org/I4210163324","display_name":"Biomedical Frontiers (United States)","ror":"https://ror.org/02yx0gd46","country_code":"US","type":"company","lineage":["https://openalex.org/I4210163324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence D. Horwitz","raw_affiliation_strings":["Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","Colorado","U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado","institution_ids":[]},{"raw_affiliation_string":"and Biomedical Frontiers, Minneapolis, Minnesota, U.S.A","institution_ids":["https://openalex.org/I4210163324"]},{"raw_affiliation_string":"Colorado","institution_ids":[]},{"raw_affiliation_string":"U.S.A","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.135,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78190317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"16","issue":"4","first_page":"523","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9750000238418579},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9660000205039978},{"id":"https://openalex.org/keywords/myocardial-necrosis","display_name":"myocardial necrosis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/iron-catalysis","display_name":"iron catalysis","score":0.5299999713897705},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.8730913400650024},{"id":"https://openalex.org/C2779412105","wikidata":"https://www.wikidata.org/wiki/Q415775","display_name":"Hydroxyethyl starch","level":2,"score":0.8631179332733154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5836919546127319},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4701828062534332},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44558489322662354},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.281056672334671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26195642352104187},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003676","descriptor_name":"Deferoxamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006895","descriptor_name":"Hydroxyethyl Starch Derivatives","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199010000-00002","doi":"https://doi.org/10.1097/00005344-199010000-00002","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199010000-00002","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:1706792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1706792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4596072598","display_name":"SYNTHESIS OF HIGH MOLECULAR WEIGHT IRON CHELATORS","funder_award_id":"R44DK037207","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8767055271","display_name":"REPERFUSION INJURY TO CORONARY ENDOTHELIUM","funder_award_id":"R01HL041661","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1608244770","https://openalex.org/W1970653700","https://openalex.org/W1998304478","https://openalex.org/W2125464792","https://openalex.org/W1992497217","https://openalex.org/W2073629863","https://openalex.org/W2048835781","https://openalex.org/W2147296656","https://openalex.org/W2464977304","https://openalex.org/W2419607429"],"abstract_inverted_index":{"Iron":[0],"catalyzes":[1],"reactions":[2],"during":[3,47],"ischemia":[4,53],"and":[5,54,146,163],"reperfusion":[6,60,145,182],"that":[7],"contribute":[8],"to":[9,28,72],"myocardial":[10,186,194],"injury.":[11,30,196],"The":[12,115],"iron-chelator":[13,46],"deferoxamine":[14,27,79,113,116,131],"blocks":[15],"these":[16],"reactions,":[17],"but":[18],"undesirable":[19],"side":[20],"effects":[21],"limit":[22],"the":[23,48,55,123,134,172,179],"clinical":[24],"potential":[25],"of":[26,37,40,52,59,102,127,144,154,175,181,193],"decrease":[29,62],"We":[31],"tested":[32],"whether":[33],"intravenous":[34],"(i.v.)":[35],"administration":[36],"high":[38],"doses":[39],"a":[41,75,100],"well-tolerated":[42],"deferoxamine-hydroxyethyl":[43],"starch":[44,86],"(DEFHES)":[45],"last":[49],"10":[50,57,152],"min":[51,58,153],"first":[56],"would":[61],"canine":[63],"infarct":[64],"size.":[65],"Fourteen":[66],"chloralose-anesthetized":[67],"mongrel":[68],"dogs":[69,93],"were":[70,137,169],"randomized":[71],"therapy":[73,111],"in":[74,133,171,188,190],"blinded":[76],"fashion":[77],"with":[78,112],"conjugate":[80],"(75":[81],"mg/kg":[82],"deferoxamine)":[83],"or":[84],"hydroxyethyl":[85],"(HES)":[87],"vehicle":[88],"alone.":[89],"Nine":[90],"other":[91],"untreated":[92],"served":[94],"as":[95,99],"controls.":[96],"Infarct":[97],"size":[98],"percentage":[101],"area":[103],"at":[104,142,151,157,178],"risk":[105],"(MI/RISK)":[106],"was":[107,118],"not":[108,184],"reduced":[109],"by":[110],"conjugate.":[114],"dose":[117,126],"five":[119],"times":[120],"greater":[121],"than":[122],"maximally":[124],"tolerated":[125],"free":[128],"deferoxamine.":[129],"Arterial":[130],"concentrations":[132],"deferoxamine-conjugate":[135],"group":[136],"0.69":[138],"+/-":[139,148],"0.09":[140],"mM":[141,150],"onset":[143],"1.37":[147],"0.05":[149],"reperfusion.":[155],"Area":[156],"risk,":[158],"ischemic":[159],"collateral":[160],"blood":[161],"flow,":[162],"heart":[164],"rate-blood":[165],"pressure":[166],"(HR/BP)":[167],"product":[168],"similar":[170],"groups.":[173],"Chelation":[174],"intravascular":[176],"iron":[177],"time":[180],"does":[183],"reduce":[185],"necrosis":[187],"an":[189],"vivo":[191],"model":[192],"ischemia-reperfusion":[195]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}