{"id":"https://openalex.org/W2007239552","doi":"https://doi.org/10.1038/srep00603","title":"Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain","display_name":"Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain","publication_year":2012,"publication_date":"2012-08-28","ids":{"openalex":"https://openalex.org/W2007239552","doi":"https://doi.org/10.1038/srep00603","mag":"2007239552","pmid":"https://pubmed.ncbi.nlm.nih.gov/22934129","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429604"},"language":"en","primary_location":{"id":"doi:10.1038/srep00603","doi":"https://doi.org/10.1038/srep00603","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep00603","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/srep00603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016353227","display_name":"Boris Rogelj","orcid":"https://orcid.org/0000-0003-3898-1943","observed_orcids":["https://orcid.org/0000-0003-3898-1943"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Boris Rogelj","raw_affiliation_strings":["Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, UK","Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057313804","display_name":"Laura E. Easton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura E. Easton","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007908742","display_name":"Gireesh K. Bogu","orcid":"https://orcid.org/0000-0002-0459-5457","observed_orcids":["https://orcid.org/0000-0002-0459-5457"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Gireesh K. Bogu","raw_affiliation_strings":["Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, S(138672)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, S(138672)","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110061210","display_name":"Lawrence Walter Stanton","orcid":"https://orcid.org/0000-0002-3392-2779","observed_orcids":["https://orcid.org/0000-0002-3392-2779"]},"institutions":[{"id":"https://openalex.org/I66068411","display_name":"Genome Institute of Singapore","ror":"https://ror.org/05k8wg936","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I66068411"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Lawrence W. Stanton","raw_affiliation_strings":["Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, S(138672)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Developmental Biology Group, Genome Institute of Singapore, 60 Biopolis Street, Singapore, S(138672)","institution_ids":["https://openalex.org/I66068411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044846726","display_name":"Gregor Rot","orcid":"https://orcid.org/0009-0001-7888-6687","observed_orcids":["https://orcid.org/0009-0001-7888-6687"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Gregor Rot","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070653907","display_name":"Toma\u017e Curk","orcid":"https://orcid.org/0000-0003-4888-7256","observed_orcids":["https://orcid.org/0000-0003-4888-7256"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Toma\u017e Curk","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073792028","display_name":"Bla\u017e Zupan","orcid":"https://orcid.org/0000-0002-5864-7056","observed_orcids":["https://orcid.org/0000-0002-5864-7056"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Bla\u017e Zupan","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Tr\u017ea\u0161ka 25, Ljubljana, SI-1000, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012095141","display_name":"Yoichiro Sugimoto","orcid":"https://orcid.org/0000-0003-1646-7679","observed_orcids":["https://orcid.org/0000-0003-1646-7679"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yoichiro Sugimoto","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059787718","display_name":"Miha Modic","orcid":"https://orcid.org/0000-0002-2894-7218","observed_orcids":["https://orcid.org/0000-0002-2894-7218"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miha Modic","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000512157","display_name":"Nejc Haberman","orcid":"https://orcid.org/0000-0001-9247-4139","observed_orcids":["https://orcid.org/0000-0001-9247-4139"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nejc Haberman","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023408849","display_name":"James R. Tollervey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1337826666","display_name":"Buck Institute for Research on Aging","ror":"https://ror.org/050sv4x28","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1337826666"]},{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"James Tollervey","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","Now at: The Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]},{"raw_affiliation_string":"Now at: The Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA, 94945, USA","institution_ids":["https://openalex.org/I1337826666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ritsuko Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsuko Fujii","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami, Hiroshima, 734-8553, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami, Hiroshima, 734-8553, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001786419","display_name":"Toru Takumi","orcid":"https://orcid.org/0000-0001-7153-266X","observed_orcids":["https://orcid.org/0000-0001-7153-266X"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Takumi","raw_affiliation_strings":["Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami, Hiroshima, 734-8553, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami, Hiroshima, 734-8553, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061919060","display_name":"Christopher E. Shaw","orcid":"https://orcid.org/0000-0003-0251-0146","observed_orcids":["https://orcid.org/0000-0003-0251-0146"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher E. Shaw","raw_affiliation_strings":["Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081437536","display_name":"Jernej Ule","orcid":"https://orcid.org/0000-0002-2452-4277","observed_orcids":["https://orcid.org/0000-0002-2452-4277","https://orcid.org/0000-0002-1464-8583"]},"institutions":[{"id":"https://openalex.org/I170203145","display_name":"MRC Laboratory of Molecular Biology","ror":"https://ror.org/00tw3jy02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I170203145","https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jernej Ule","raw_affiliation_strings":["MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK","institution_ids":["https://openalex.org/I170203145"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5061919060","https://openalex.org/A5081437536"],"corresponding_institution_ids":["https://openalex.org/I170203145","https://openalex.org/I183935753"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":7.6003,"has_fulltext":true,"cited_by_count":271,"citation_normalized_percentile":{"value":0.98528803,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"603","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.8467000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.1517000049352646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fus","display_name":"FUS","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tdp-43","display_name":"TDP-43","score":0.968999981880188},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.902999997138977},{"id":"https://openalex.org/keywords/nascent-rna","display_name":"nascent RNA","score":0.9869999885559082},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9409999847412109},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":1.0},{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neuronal-development","display_name":"neuronal development","score":0.7260000109672546},{"id":"https://openalex.org/keywords/iclip","display_name":"iCLIP","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.7941176891326904},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7516604661941528},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.7170093655586243},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.6644964814186096},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.64451664686203},{"id":"https://openalex.org/C2776939681","wikidata":"https://www.wikidata.org/wiki/Q18579","display_name":"Frontotemporal lobar degeneration","level":5,"score":0.5843274593353271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5782006978988647},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5567095279693604},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5276008248329163},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3715995252132416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36546534299850464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3518839478492737},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.1881067156791687},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12829360365867615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07996243238449097},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023061","descriptor_name":"Gene Order","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034702","descriptor_name":"RNA-Binding Protein FUS","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/srep00603","doi":"https://doi.org/10.1038/srep00603","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep00603","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2429678","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429604","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3429604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3429604","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:22934129","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22934129","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:edoc.mdc-berlin.de:21797","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/21797/1/21797oa.pdf","pdf_url":"http://edoc.mdc-berlin.de/21797/1/21797oa.pdf","source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1392065","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1392065/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SCIENTIFIC REPORTS , 2 (ARTN 603) (2012)","raw_type":"Article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/a51a15fa-b8a1-4f60-ac29-fc5a9e0b4a84","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/a51a15fa-b8a1-4f60-ac29-fc5a9e0b4a84","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rogelj, B, Easton, L E, Bogu, G K, Stanton, L W, Rot, G, Curk, T, Zupan, B, Sugimoto, Y, Modic, M, Haberman, N, Tollervey, J, Fujii, R, Takumi, T, Shaw, C E & Ule, J 2012, 'Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain', Scientific Reports, vol. 2, 603, pp. -. https://doi.org/10.1038/srep00603","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/srep00603","doi":"https://doi.org/10.1038/srep00603","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep00603","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G135650358","display_name":"Transport in RNA vezava proteinov TDP-43 in FUS - implikacije za ALS/FTLD spekter nevrodegenerativnih bolezni (Slovene)","funder_award_id":"J3-4026","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G2549921100","display_name":"RNA processing proteins and neurodegeneration: exploring mechanisms and modelling disease","funder_award_id":"MC_G1000733","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3604908533","display_name":"Metode za povezovanje podatkov in znanja v sistemski biologiji mre\u017e (Slovene)","funder_award_id":"J2-2197","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G4622468291","display_name":"Molecular Pathogenesis of Familial Amyotrophic Lateral SclerosisType 6","funder_award_id":"22500335","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4954315856","display_name":"RNA processing proteins and neurodegeneration: exploring mechanisms and modelling disease.","funder_award_id":"089701","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5197067802","display_name":"Tehnologije znanj za odkrivanje novih zdravilnih u\u010dinkovin: analiza in na\u010drtovnje eksperimentov v visokozmogljivostni genetiki (Slovene)","funder_award_id":"L2-1112","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G5349355312","display_name":"RNA processing proteins and neurodegeneration: exploring mechanisms and modelling disease.","funder_award_id":"089701/Z/09/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5769677123","display_name":"Artificial Intelligence and Intelligent Systems","funder_award_id":"P2-0209","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G7879866177","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8141507392","display_name":"Modeling the transcriptome","funder_award_id":"Z7-3665","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8393510347","display_name":"Mapping functional protein-RNA interactions to identify new targets for oligonucleotide-based therapy.","funder_award_id":"206726","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1619082318","https://openalex.org/W1729426031","https://openalex.org/W1967073977","https://openalex.org/W1969196565","https://openalex.org/W1974272975","https://openalex.org/W1977312702","https://openalex.org/W1980913885","https://openalex.org/W1989168454","https://openalex.org/W1995635963","https://openalex.org/W2001381614","https://openalex.org/W2003618511","https://openalex.org/W2010615446","https://openalex.org/W2012782745","https://openalex.org/W2034221476","https://openalex.org/W2036583346","https://openalex.org/W2038438413","https://openalex.org/W2044117548","https://openalex.org/W2044417243","https://openalex.org/W2045402423","https://openalex.org/W2058416613","https://openalex.org/W2073164785","https://openalex.org/W2073573764","https://openalex.org/W2074726646","https://openalex.org/W2075186362","https://openalex.org/W2079470515","https://openalex.org/W2080505162","https://openalex.org/W2080964315","https://openalex.org/W2081534563","https://openalex.org/W2088017477","https://openalex.org/W2090217559","https://openalex.org/W2097630727","https://openalex.org/W2100607589","https://openalex.org/W2101042581","https://openalex.org/W2103214559","https://openalex.org/W2108191354","https://openalex.org/W2114532236","https://openalex.org/W2116086426","https://openalex.org/W2117428493","https://openalex.org/W2118823143","https://openalex.org/W2119288587","https://openalex.org/W2122886737","https://openalex.org/W2128830216","https://openalex.org/W2131636181","https://openalex.org/W2132803382","https://openalex.org/W2136949432","https://openalex.org/W2137807688","https://openalex.org/W2148156439","https://openalex.org/W2151371344","https://openalex.org/W2151994495","https://openalex.org/W2160503216","https://openalex.org/W2184199894","https://openalex.org/W6998504798"],"related_works":["https://openalex.org/W2089423734","https://openalex.org/W2118922947","https://openalex.org/W2112538318","https://openalex.org/W2955026850","https://openalex.org/W2261708844","https://openalex.org/W2020184434","https://openalex.org/W2136949432","https://openalex.org/W3011323955","https://openalex.org/W2392894136","https://openalex.org/W2531565322"],"abstract_inverted_index":{"Fused":[0],"in":[1,45,74,97,105,118,141],"sarcoma":[2],"(FUS)":[3],"and":[4,20,42,67,129],"TAR":[5],"DNA-binding":[6],"protein":[7],"43":[8],"(TDP-43)":[9],"are":[10],"RNA-binding":[11],"proteins":[12,136],"pathogenetically":[13],"linked":[14],"to":[15,65,82],"amyotrophic":[16],"lateral":[17],"sclerosis":[18],"(ALS)":[19],"frontotemporal":[21],"lobar":[22],"degeneration":[23],"(FTLD),":[24],"but":[25],"it":[26],"is":[27,86],"not":[28,113],"known":[29],"if":[30],"they":[31],"regulate":[32,137],"the":[33,54,58,108,119,124],"same":[34],"transcripts.":[35],"We":[36,111],"addressed":[37],"this":[38],"question":[39],"using":[40],"crosslinking":[41,102],"immunoprecipitation":[43],"(iCLIP)":[44],"mouse":[46],"brain,":[47],"which":[48],"showed":[49],"that":[50,78,134,139],"FUS":[51,79,96,104,128],"binds":[52],"along":[53],"whole":[55],"length":[56],"of":[57,89,103],"nascent":[59],"RNA":[60,120],"with":[61,100],"limited":[62],"sequence":[63],"specificity":[64],"GGU":[66],"related":[68],"motifs.":[69],"A":[70],"saw-tooth":[71],"binding":[72,121],"pattern":[73],"long":[75],"genes":[76,138],"demonstrated":[77,92],"remains":[80],"bound":[81],"pre-mRNAs":[83],"until":[84],"splicing":[85],"completed.":[87],"Analysis":[88],"FUS(-/-)":[90],"brain":[91],"a":[93,115],"role":[94],"for":[95],"alternative":[98],"splicing,":[99],"increased":[101],"introns":[106],"around":[107],"repressed":[109],"exons.":[110],"did":[112],"observe":[114],"significant":[116],"overlap":[117],"sites":[122],"or":[123],"exons":[125],"regulated":[126],"by":[127],"TDP-43.":[130],"Nevertheless,":[131],"we":[132],"found":[133],"both":[135],"function":[140],"neuronal":[142],"development.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":22},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}