{"id":"https://openalex.org/W2007238841","doi":"https://doi.org/10.1002/mrd.1080330412","title":"Monoclonal antibody AG7 inhibits fertilization post sperm\u2010zona binding","display_name":"Monoclonal antibody AG7 inhibits fertilization post sperm\u2010zona binding","publication_year":1992,"publication_date":"1992-12-01","ids":{"openalex":"https://openalex.org/W2007238841","doi":"https://doi.org/10.1002/mrd.1080330412","mag":"2007238841","pmid":"https://pubmed.ncbi.nlm.nih.gov/1282025"},"language":"en","primary_location":{"id":"doi:10.1002/mrd.1080330412","doi":"https://doi.org/10.1002/mrd.1080330412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.1080330412","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062599982","display_name":"Cosima V. M. Brucker","orcid":"https://orcid.org/0000-0001-7172-5218","observed_orcids":["https://orcid.org/0000-0001-7172-5218"]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Cosima Brucker","raw_affiliation_strings":["Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507","I. Women's Hospital, Ludwing-Maximilians-University, Technical University, Munich, Federal Republic of Germany","The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"I. Women's Hospital, Ludwing-Maximilians-University, Technical University, Munich, Federal Republic of Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]},{"raw_affiliation_string":"The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111389630","display_name":"Bruce A. Sandow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce A. Sandow","raw_affiliation_strings":["Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia","The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050452260","display_name":"P F Blackmore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter F. Blackmore","raw_affiliation_strings":["Department of Pharmacology, Eastern Virginia Medical School, Norfolk, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Eastern Virginia Medical School, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004324970","display_name":"Grayson B. Lipford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156802259","display_name":"Eastern Virginia Medical School","ror":"https://ror.org/056hr4255","country_code":"US","type":"education","lineage":["https://openalex.org/I156802259"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Grayson B. Lipford","raw_affiliation_strings":["Department of Immunology and Microbiology, Eastern Virginia Medical School, Norfolk, Virginia","Department of Microbiology and Hygiene, Technical University, Munich, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Eastern Virginia Medical School, Norfolk, Virginia","institution_ids":["https://openalex.org/I156802259"]},{"raw_affiliation_string":"Department of Microbiology and Hygiene, Technical University, Munich, Federal Republic of Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113625771","display_name":"Gary D. Hodgen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gary D. Hodgen","raw_affiliation_strings":["The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Virginia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113625771"],"corresponding_institution_ids":[],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":null,"fwci":1.0951,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70355805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"33","issue":"4","first_page":"451","last_page":"462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fertilization-inhibition","display_name":"fertilization inhibition","score":0.890999972820282},{"id":"https://openalex.org/keywords/human-spermatozoa","display_name":"human spermatozoa","score":0.6600000262260437},{"id":"https://openalex.org/keywords/zona-pellucida-binding","display_name":"zona pellucida binding","score":0.8970000147819519},{"id":"https://openalex.org/keywords/acrosome-reaction","display_name":"acrosome reaction","score":0.8230000138282776},{"id":"https://openalex.org/keywords/calcium-influx","display_name":"calcium influx","score":0.8610000014305115},{"id":"https://openalex.org/keywords/sperm-capacitation","display_name":"sperm capacitation","score":0.8569999933242798},{"id":"https://openalex.org/keywords/sperm-plasma-membrane","display_name":"sperm plasma membrane","score":0.6620000004768372},{"id":"https://openalex.org/keywords/steroid-hormone-receptors","display_name":"steroid hormone receptors","score":0.5400000214576721},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.8370000123977661},{"id":"https://openalex.org/keywords/antisperm-antibodies","display_name":"antisperm antibodies","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.8351089954376221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7698873281478882},{"id":"https://openalex.org/C2780301668","wikidata":"https://www.wikidata.org/wiki/Q1728362","display_name":"Capacitation","level":3,"score":0.7352361679077148},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.7003074884414673},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6376287937164307},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6271275281906128},{"id":"https://openalex.org/C2779995066","wikidata":"https://www.wikidata.org/wiki/Q163261","display_name":"Acrosome reaction","level":3,"score":0.5795498490333557},{"id":"https://openalex.org/C2776010925","wikidata":"https://www.wikidata.org/wiki/Q219841","display_name":"Zona pellucida","level":4,"score":0.5175853967666626},{"id":"https://openalex.org/C2778252442","wikidata":"https://www.wikidata.org/wiki/Q421111","display_name":"Acrosome","level":3,"score":0.5165478587150574},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5033494830131531},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.4321586489677429},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4189947545528412},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.38860195875167847},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3102774918079376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2673282027244568},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.21338090300559998},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11946240067481995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000177","descriptor_name":"Acrosome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005306","descriptor_name":"Fertilization","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005306","descriptor_name":"Fertilization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013094","descriptor_name":"Spermatozoa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrd.1080330412","doi":"https://doi.org/10.1002/mrd.1080330412","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrd.1080330412","pdf_url":null,"source":{"id":"https://openalex.org/S125242520","display_name":"Molecular Reproduction and Development","issn_l":"1040-452X","issn":["1040-452X","1098-2795"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Reproduction and Development","raw_type":"journal-article"},{"id":"pmid:1282025","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1282025","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular reproduction and development","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W87846111","https://openalex.org/W97075877","https://openalex.org/W101879796","https://openalex.org/W109951615","https://openalex.org/W1533803295","https://openalex.org/W1558812914","https://openalex.org/W1561146911","https://openalex.org/W1577009981","https://openalex.org/W1586947583","https://openalex.org/W1588308265","https://openalex.org/W1963528131","https://openalex.org/W1964425881","https://openalex.org/W1977961510","https://openalex.org/W1978279609","https://openalex.org/W1980556867","https://openalex.org/W1982811801","https://openalex.org/W1984843908","https://openalex.org/W1993636207","https://openalex.org/W1997409229","https://openalex.org/W1998071991","https://openalex.org/W1999352791","https://openalex.org/W2002983094","https://openalex.org/W2004425108","https://openalex.org/W2012225661","https://openalex.org/W2013597575","https://openalex.org/W2020281299","https://openalex.org/W2035820040","https://openalex.org/W2037601841","https://openalex.org/W2037834736","https://openalex.org/W2043016977","https://openalex.org/W2046047809","https://openalex.org/W2047841570","https://openalex.org/W2056903551","https://openalex.org/W2060183661","https://openalex.org/W2085674561","https://openalex.org/W2097528604","https://openalex.org/W2100837269","https://openalex.org/W2121862501","https://openalex.org/W2137834724","https://openalex.org/W2141260882","https://openalex.org/W2149209838","https://openalex.org/W2151413687","https://openalex.org/W2152517651","https://openalex.org/W2157498705","https://openalex.org/W2161629160","https://openalex.org/W2173056301","https://openalex.org/W2279657792","https://openalex.org/W2419065443","https://openalex.org/W4293316382","https://openalex.org/W4299950877"],"related_works":["https://openalex.org/W2050562386","https://openalex.org/W1978416358","https://openalex.org/W1973887062","https://openalex.org/W2014633952","https://openalex.org/W115647407","https://openalex.org/W1976450951","https://openalex.org/W2046047809","https://openalex.org/W2416468294","https://openalex.org/W2046708077","https://openalex.org/W2037090711"],"abstract_inverted_index":{"Monoclonal":[0],"antibodies":[1],"(mAbs)":[2],"against":[3],"sperm":[4,29,68,79,88,98,105,123,171,247,266],"cells":[5,89],"are":[6],"currently":[7],"being":[8],"used":[9],"in":[10,18,73,136,139,199,201,226,251],"an":[11,256],"effort":[12],"to":[13,60,164,170,179,195],"define":[14],"spermatozoal":[15],"antigens":[16],"involved":[17,250],"the":[19,37,74,92,97,115,180,188,205,213,220,252,265],"fertilization":[20,141,146,165,253],"process.":[21],"We":[22],"have":[23],"produced":[24],"a":[25,48,67,137,210,229,246],"number":[26],"of":[27,33,42,50,77,86,106,114,174,185,219,232],"anti-human":[28],"mAbs":[30],"by":[31,82,147,242],"immunization":[32],"female":[34],"mice":[35],"with":[36,156,177,187,228],"100,000":[38],"x":[39],"g":[40],"supernatant":[41],"octylglycoside-solubilized":[43],"washed":[44],"human":[45,78],"sperm.":[46],"From":[47],"panel":[49],"mAbs,":[51],"1":[52],"antibody,":[53],"AG7,":[54,244],"was":[55,101,118,193],"selected":[56],"and":[57,124,132,151],"characterized":[58],"due":[59],"its":[61],"fertilization-inhibiting":[62],"characteristics.":[63],"MAb":[64,191],"AG7":[65,144,192],"defines":[66],"acrosome":[69,214],"antigen-1":[70],"(SAA-1)":[71],"located":[72,263],"acrosomal":[75],"region":[76],"as":[80],"evaluated":[81],"indirect":[83],"immunofluorescence.":[84],"Staining":[85],"life":[87],"indicated":[90],"that":[91,239],"antigen":[93,221,248],"is":[94,153,224,245],"present":[95],"on":[96,104,121],"surface.":[99],"SAA-1":[100,117],"also":[102],"found":[103],"several":[107],"other":[108],"mammalian":[109],"species,":[110],"implying":[111],"evolutionary":[112],"conservation":[113],"antigen.":[116],"first":[119],"observed":[120],"testicular":[122],"can":[125],"be":[126,168],"followed":[127],"through":[128],"epididymal":[129],"transit,":[130],"ejaculation,":[131],"capacitation.":[133],"When":[134],"applied":[135],"mouse":[138],"vitro":[140,202],"assay,":[142],"mAb":[143,243],"inhibits":[145],"greater":[148],"than":[149],"95%,":[150],"inhibition":[152,158,173,184],"dose":[154],"dependent,":[155],"half-maximal":[157],"at":[159],"0.8":[160],"micrograms/ml.":[161],"The":[162,236],"block":[163],"could":[166],"not":[167],"attributed":[169],"agglutination,":[172],"motility,":[175],"interference":[176],"adhesion":[178],"zona":[181],"pellucida,":[182],"or":[183,260],"fusion":[186],"oocyte":[189],"membrane.":[190,268],"demonstrated":[194],"inhibit":[196],"calcium":[197],"influx":[198],"spermatozoa":[200],"(measured":[203],"using":[204],"fluorescent":[206],"indicator":[207],"fura":[208],"2),":[209],"prerequisite":[211],"for":[212],"reaction.":[215],"Initial":[216],"biochemical":[217],"characterization":[218],"suggests":[222],"it":[223],"proteinlike":[225],"nature,":[227],"molecular":[230],"weight":[231],"approximately":[233],"220":[234],"kD.":[235],"results":[237],"suggest":[238],"SAA-1,":[240],"identified":[241],"crucially":[249],"process,":[254],"possibly":[255],"atypical":[257],"steroid":[258],"receptor":[259],"ion":[261],"channel":[262],"within":[264],"plasma":[267]},"counts_by_year":[{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
