{"id":"https://openalex.org/W2007233648","doi":"https://doi.org/10.1177/0748233713498454","title":"Antioxidant profile of constituents isolated from Polygonatum verticillatum rhizomes","display_name":"Antioxidant profile of constituents isolated from Polygonatum verticillatum rhizomes","publication_year":2013,"publication_date":"2013-09-30","ids":{"openalex":"https://openalex.org/W2007233648","doi":"https://doi.org/10.1177/0748233713498454","mag":"2007233648","pmid":"https://pubmed.ncbi.nlm.nih.gov/24081628"},"language":"en","primary_location":{"id":"doi:10.1177/0748233713498454","doi":"https://doi.org/10.1177/0748233713498454","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233713498454","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100772789","display_name":"Haroon Zaman Khan","orcid":"https://orcid.org/0000-0002-1736-4404","observed_orcids":["https://orcid.org/0000-0002-1736-4404"]},"institutions":[{"id":"https://openalex.org/I181063083","display_name":"Abdul Wali Khan University Mardan","ror":"https://ror.org/03b9y4e65","country_code":"PK","type":"education","lineage":["https://openalex.org/I181063083"]},{"id":"https://openalex.org/I32401161","display_name":"Gandhara University","ror":"https://ror.org/05snv9327","country_code":"PK","type":"education","lineage":["https://openalex.org/I32401161"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Haroon Khan","raw_affiliation_strings":["Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan","Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan","#N# 1Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan","2Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan","institution_ids":["https://openalex.org/I181063083"]},{"raw_affiliation_string":"Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan","institution_ids":["https://openalex.org/I32401161"]},{"raw_affiliation_string":"#N# 1Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan","institution_ids":["https://openalex.org/I32401161"]},{"raw_affiliation_string":"2Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan","institution_ids":["https://openalex.org/I181063083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000462968","display_name":"Muhammad Saeed","orcid":"https://orcid.org/0000-0001-9949-4327","observed_orcids":["https://orcid.org/0000-0001-9949-4327"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Saeed","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101524454","display_name":"Naveed Muhammad","orcid":"https://orcid.org/0000-0001-5965-1965","observed_orcids":["https://orcid.org/0000-0001-5965-1965"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Naveed Muhammad","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644307","display_name":"Abdur Rauf","orcid":"https://orcid.org/0000-0003-2429-5491","observed_orcids":["https://orcid.org/0000-0003-2429-5491","https://orcid.org/0000-0002-5113-8400"]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Abdur Rauf","raw_affiliation_strings":["Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical Sciences, University of Peshawar, Peshawar, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113976828","display_name":"Amir Zada Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amir Zada Khan","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071967428","display_name":"Rooh Ullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36001604","display_name":"University of Peshawar","ror":"https://ror.org/02t2qwf81","country_code":"PK","type":"education","lineage":["https://openalex.org/I36001604"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rooh Ullah","raw_affiliation_strings":["Department of Pharmacy, University of Peshawar, Peshawar, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, University of Peshawar, Peshawar, Pakistan","institution_ids":["https://openalex.org/I36001604"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100772789"],"corresponding_institution_ids":["https://openalex.org/I181063083","https://openalex.org/I32401161"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4167,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.54574612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"32","issue":"1","first_page":"138","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.42160001397132874,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.42160001397132874,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1876000016927719,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.16040000319480896,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygonatum-verticillatum","display_name":"Polygonatum verticillatum","score":1.0},{"id":"https://openalex.org/keywords/rhizome","display_name":"rhizome","score":0.9169999957084656},{"id":"https://openalex.org/keywords/diosgenin","display_name":"diosgenin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/santonin","display_name":"santonin","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9459999799728394},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.9779999852180481},{"id":"https://openalex.org/keywords/reducing-power","display_name":"reducing power","score":0.8899999856948853},{"id":"https://openalex.org/keywords/ic50","display_name":"IC50","score":0.6669999957084656},{"id":"https://openalex.org/keywords/phytochemical-constituents","display_name":"phytochemical constituents","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2776601336","wikidata":"https://www.wikidata.org/wiki/Q1107734","display_name":"Diosgenin","level":2,"score":0.9926607608795166},{"id":"https://openalex.org/C134550120","wikidata":"https://www.wikidata.org/wiki/Q184208","display_name":"Rhizome","level":2,"score":0.8935607671737671},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.8272570371627808},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6702947020530701},{"id":"https://openalex.org/C2778564307","wikidata":"https://www.wikidata.org/wiki/Q207653","display_name":"Saponin","level":3,"score":0.5574458241462708},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.538735568523407},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5048835873603821},{"id":"https://openalex.org/C2781401929","wikidata":"https://www.wikidata.org/wiki/Q5205953","display_name":"DPPH","level":3,"score":0.45394590497016907},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3530804514884949},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.272906094789505},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23910808563232422},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09663531184196472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.04874777793884277},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027343","descriptor_name":"Rhizome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D031384","descriptor_name":"Polygonatum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/0748233713498454","doi":"https://doi.org/10.1177/0748233713498454","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233713498454","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},{"id":"pmid:24081628","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24081628","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and industrial health","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1223049747","https://openalex.org/W1553435998","https://openalex.org/W1588324738","https://openalex.org/W1968117805","https://openalex.org/W2003944181","https://openalex.org/W2021514130","https://openalex.org/W2024584275","https://openalex.org/W2053249752","https://openalex.org/W2055383341","https://openalex.org/W2061343438","https://openalex.org/W2100520075","https://openalex.org/W2116526332","https://openalex.org/W2141522587","https://openalex.org/W2149252999","https://openalex.org/W2158324392","https://openalex.org/W2185148515","https://openalex.org/W2395130448","https://openalex.org/W2436897806","https://openalex.org/W3106422356","https://openalex.org/W4205755059","https://openalex.org/W4206185067","https://openalex.org/W4249329707"],"related_works":["https://openalex.org/W3183593858","https://openalex.org/W2376314407","https://openalex.org/W2799992390","https://openalex.org/W4210891028","https://openalex.org/W2063549956","https://openalex.org/W2359352601","https://openalex.org/W2113754425","https://openalex.org/W4321353341","https://openalex.org/W4386788008","https://openalex.org/W2330472603"],"abstract_inverted_index":{"The":[0,37,54,85],"purpose":[1],"of":[2,12,45,115,118],"the":[3,9,91,102,113,116,119],"current":[4],"study":[5],"was":[6,67],"to":[7],"estimate":[8],"antioxidant":[10,107],"profile":[11],"two":[13],"compounds,":[14],"diosgenin":[15,47,64,78],"and":[16,28,48,65,69,79,95],"santonin,":[17],"isolated":[18,103],"from":[19],"Polygonatum":[20],"verticillatum":[21],"rhizomes.":[22],"Stable":[23],"free":[24,41],"radical,":[25],"2,":[26],"2-diphenyl-1-picrylhydrazyl":[27],"reducing":[29,75],"power":[30,76],"assays":[31],"were":[32,93],"employed":[33],"for":[34,62,89],"this":[35],"purpose.":[36],"results":[38,114],"showed":[39],"profound":[40],"radical":[42],"scavenging":[43],"effect":[44],"both":[46,63,90,101],"santonin":[49,66,80],"in":[50,74],"a":[51],"concentration-dependent":[52],"manner.":[53],"calculated":[55],"half":[56],"maximal":[57],"inhibitory":[58],"concentration":[59],"(IC50)":[60],"values":[61,88],"65.80":[68],"50.03":[70],"\u03bcg/ml,":[71,97],"respectively.":[72,98],"Similarly,":[73],"assay,":[77],"exhibited":[81],"marked":[82],"quenching":[83],"effect.":[84],"corresponding":[86],"IC50":[87],"compounds":[92,104],"62.10":[94],"46.40":[96],"In":[99],"conclusion,":[100],"have":[105],"strong":[106],"potential,":[108],"which":[109],"is":[110],"consistent":[111],"with":[112],"extracts":[117],"plant.":[120]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}