{"id":"https://openalex.org/W2007232643","doi":"https://doi.org/10.1080/14786411003781515","title":"Antihistaminic and antiviral activities of steroids ofTurbinaria conoides","display_name":"Antihistaminic and antiviral activities of steroids ofTurbinaria conoides","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W2007232643","doi":"https://doi.org/10.1080/14786411003781515","mag":"2007232643","pmid":"https://pubmed.ncbi.nlm.nih.gov/21462071"},"language":"en","primary_location":{"id":"doi:10.1080/14786411003781515","doi":"https://doi.org/10.1080/14786411003781515","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786411003781515","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100600929","display_name":"Shanmugam Sadish Kumar","orcid":"https://orcid.org/0000-0002-9890-3034","observed_orcids":["https://orcid.org/0000-0002-9890-3034"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"S. Sadish Kumar","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ITS Paramedical College (Pharmacy), Ghaziabad, Uttar Pradesh, India. jesisjes@yahoo.co.in","Department of Pharmaceutical Chemistry , ITS Paramedical College (Pharmacy) , Ghaziabad, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ITS Paramedical College (Pharmacy), Ghaziabad, Uttar Pradesh, India. jesisjes@yahoo.co.in","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry , ITS Paramedical College (Pharmacy) , Ghaziabad, Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100861699","display_name":"Yatendra Kumar","orcid":"https://orcid.org/0000-0002-6651-6371","observed_orcids":["https://orcid.org/0000-0002-6651-6371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Kumar","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, ITS Paramedical College (Pharmacy), Ghaziabad, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, ITS Paramedical College (Pharmacy), Ghaziabad, Uttar Pradesh, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111986131","display_name":"M. S. Y. Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19716509","display_name":"Jamia Hamdard","ror":"https://ror.org/03dwxvb85","country_code":"IN","type":"education","lineage":["https://openalex.org/I19716509"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M.S.Y. Khan","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi, India","institution_ids":["https://openalex.org/I19716509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111636068","display_name":"J Anbu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J. Anbu","raw_affiliation_strings":["Department of Pharmacology, Vel's College of Pharmacy, Old Pallavaram, Chennai 600117, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vel's College of Pharmacy, Old Pallavaram, Chennai 600117, Tamil Nadu, India","institution_ids":["https://openalex.org/I138876546"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040662398","display_name":"Erik De Clercq","orcid":"https://orcid.org/0000-0002-2985-8890","observed_orcids":["https://orcid.org/0000-0002-2985-8890"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"E. De Clercq","raw_affiliation_strings":["Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I24156275","https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100600929"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3314,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.60031245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"25","issue":"7","first_page":"723","last_page":"729"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/turbinaria-conoides","display_name":"Turbinaria conoides","score":1.0},{"id":"https://openalex.org/keywords/antihistaminic-activity","display_name":"antihistaminic activity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.996999979019165},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/brown-algae","display_name":"brown algae","score":0.7179999947547913},{"id":"https://openalex.org/keywords/marine-natural-products","display_name":"marine natural products","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.8459042310714722},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.6838616728782654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6628463268280029},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.571185290813446},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5595403909683228},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5463824272155762},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46160000562667847},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.4322754442691803},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.4121350049972534},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.37384188175201416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31485170125961304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21048042178153992},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10873517394065857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10062623023986816}],"mesh":[{"descriptor_ui":"D000459","descriptor_name":"Phaeophyceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013141","descriptor_name":"Spiro Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013265","descriptor_name":"Stigmasterol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013265","descriptor_name":"Stigmasterol","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013265","descriptor_name":"Stigmasterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1080/14786411003781515","doi":"https://doi.org/10.1080/14786411003781515","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786411003781515","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:21462071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21462071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/465095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21462071","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural product research, vol. 25 (7), Art.No. PII 935854616, (723-9)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W80659108","https://openalex.org/W1000586621","https://openalex.org/W1996984631","https://openalex.org/W2009182409","https://openalex.org/W2014145303","https://openalex.org/W2037717910","https://openalex.org/W2040337456","https://openalex.org/W2048942851","https://openalex.org/W2050689015","https://openalex.org/W2058792095","https://openalex.org/W2062876803","https://openalex.org/W2068496295","https://openalex.org/W2075406203","https://openalex.org/W2100401282","https://openalex.org/W2109439396","https://openalex.org/W2126488893","https://openalex.org/W2795737932","https://openalex.org/W4285719527","https://openalex.org/W4401212471"],"related_works":["https://openalex.org/W2100401282","https://openalex.org/W37115494","https://openalex.org/W2079491230","https://openalex.org/W2757485501","https://openalex.org/W4386757397","https://openalex.org/W2257696773","https://openalex.org/W2134420769","https://openalex.org/W2183771769","https://openalex.org/W2087789731","https://openalex.org/W2062863586"],"abstract_inverted_index":{"The":[0,46,127],"steroids":[1],"3,6,17-trihydroxy-stigmasta-4,7,24(28)-triene":[2],"(A)":[3],"and":[4,21,43,64,73,84],"14,15,18,20-diepoxyturbinarin":[5,162],"(B)":[6,163],"were":[7,37,80,86,106],"isolated":[8,35],"from":[9],"the":[10,34,59,65,70,75,78,109,112,118,141,150],"cyclohexane":[11],"extract":[12],"of":[13,58,69,77,149],"brown":[14],"alga,":[15],"Turbinaria":[16],"conoides":[17],"(J.":[18],"Agardh)":[19],"Kutzing,":[20],"have":[22],"been":[23],"reported":[24],"for":[25,39,108,134],"their":[26],"antimicrobial":[27],"activity":[28,83,103],"by":[29,94],"us.":[30],"In":[31],"this":[32],"study,":[33],"compounds":[36,79,110],"evaluated":[38],"comprehensive":[40],"antihistaminic,":[41],"antiviral":[42,102],"cytotoxicity":[44,85,105],"screening.":[45],"antihistaminic":[47,171],"study":[48],"was":[49,132,145],"performed":[50,87],"using":[51],"in":[52,74,88,111],"vitro":[53],"standard":[54],"animal":[55],"models.":[56],"Evaluation":[57],"potency":[60],"(EC(50)),":[61],"affinity":[62],"(pA(2))":[63],"maximal":[66],"response":[67],"(E(max))":[68],"histamine":[71],"alone":[72],"presence":[76],"determined.":[81],"Antiviral":[82],"Crandell-Rees":[89],"feline":[90],"kidney":[91],"(CRFK)":[92],"cells":[93],"a":[95,168],"colorimetric":[96],"formazan-based":[97],"MTS":[98],"assay.":[99],"No":[100],"significant":[101,129],"or":[104],"observed":[107,133],"CRFK":[113],"cells.":[114],"Compound":[115],"A":[116],"inhibited":[117],"histamine-induced":[119],"concentration":[120],"at":[121,140],"20":[122],"\u00b5g":[123,156],"mL(-1)(p":[124],"<":[125,138],"0.05).":[126],"most":[128],"inhibition":[130],"(97%)":[131],"compound":[135],"B":[136],"(p":[137],"0.01)":[139],"same":[142],"concentration,":[143],"which":[144],"comparable":[146],"to":[147],"that":[148,161],"positive":[151],"control":[152],"chlorpheniramine":[153],"maleate":[154],"(10":[155],"mL(-1)).":[157],"This":[158],"potentiality":[159],"suggests":[160],"can":[164],"be":[165],"developed":[166],"as":[167],"new":[169],"lead":[170],"agent.":[172]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}