{"id":"https://openalex.org/W2007202879","doi":"https://doi.org/10.1074/jbc.273.4.1990","title":"Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase","display_name":"Suppression of Leukotriene Formation in RBL-2H3 Cells That Overexpressed Phospholipid Hydroperoxide Glutathione Peroxidase","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2007202879","doi":"https://doi.org/10.1074/jbc.273.4.1990","mag":"2007202879","pmid":"https://pubmed.ncbi.nlm.nih.gov/9442035"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.4.1990","doi":"https://doi.org/10.1074/jbc.273.4.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.4.1990","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.273.4.1990","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102954950","display_name":"Hirotaka Imai","orcid":"https://orcid.org/0000-0003-4755-4847","observed_orcids":["https://orcid.org/0000-0003-4755-4847"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Imai","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan","School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091860250","display_name":"Kazuki Narashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Narashima","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003389142","display_name":"Masayoshi Arai","orcid":"https://orcid.org/0000-0003-2771-1948","observed_orcids":["https://orcid.org/0000-0003-2771-1948"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayoshi Arai","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hikaru Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru Sakamoto","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113642709","display_name":"Nobuyoshi Chiba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276056","display_name":"Japan Energy Inc. (Japan)","ror":"https://ror.org/04re4vr44","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405276056"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyoshi Chiba","raw_affiliation_strings":["Japan Energy Corporation, 3-17-35 Niizo-Minami, Toda-shi, Saitama 335, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japan Energy Corporation, 3-17-35 Niizo-Minami, Toda-shi, Saitama 335, Japan","institution_ids":["https://openalex.org/I4405276056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010831372","display_name":"Yasuhito Nakagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yasuhito Nakagawa","raw_affiliation_strings":["School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010831372"],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":4.8325,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.96602871,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"273","issue":"4","first_page":"1990","last_page":"1997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.06599999964237213,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukotriene-biosynthesis","display_name":"leukotriene biosynthesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":1.0},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.9039999842643738},{"id":"https://openalex.org/keywords/5-hydroxyeicosatetraenoic-acid","display_name":"5-hydroxyeicosatetraenoic acid","score":0.8569999933242798},{"id":"https://openalex.org/keywords/5-hydroperoxyeicosatetraenoic-acid","display_name":"5-hydroperoxyeicosatetraenoic acid","score":0.9169999957084656},{"id":"https://openalex.org/keywords/12-hydroperoxyeicosatetraenoic-acid","display_name":"12-hydroperoxyeicosatetraenoic acid","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fatty-acid-hydroperoxides","display_name":"fatty acid hydroperoxides","score":0.906000018119812},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C2781264002","wikidata":"https://www.wikidata.org/wiki/Q3724651","display_name":"Phospholipid-hydroperoxide glutathione peroxidase","level":5,"score":0.8962658643722534},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.8643583059310913},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.6749922037124634},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6211940050125122},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.58447265625},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5736968517303467},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.557394802570343},{"id":"https://openalex.org/C2779543280","wikidata":"https://www.wikidata.org/wiki/Q2704310","display_name":"Leukotriene C4","level":4,"score":0.5501950979232788},{"id":"https://openalex.org/C2779630222","wikidata":"https://www.wikidata.org/wiki/Q65658502","display_name":"Hydroxyeicosatetraenoic acid","level":4,"score":0.4766141474246979},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.47175341844558716},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46803903579711914},{"id":"https://openalex.org/C90342290","wikidata":"https://www.wikidata.org/wiki/Q94234745","display_name":"Arachidonate 5-lipoxygenase","level":4,"score":0.43612080812454224},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42972779273986816},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.36522385478019714},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.31000059843063354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23613637685775757},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08158084750175476},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001094","descriptor_name":"Arachidonate 5-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006893","descriptor_name":"Hydroxyeicosatetraenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007476","descriptor_name":"Ionophores","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051140","descriptor_name":"Selenoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.4.1990","doi":"https://doi.org/10.1074/jbc.273.4.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.4.1990","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9442035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9442035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.4.1990","doi":"https://doi.org/10.1074/jbc.273.4.1990","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.4.1990","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W60704706","https://openalex.org/W561754329","https://openalex.org/W1205458192","https://openalex.org/W1509307264","https://openalex.org/W1516881609","https://openalex.org/W1529804537","https://openalex.org/W1573580543","https://openalex.org/W1591054099","https://openalex.org/W1591150027","https://openalex.org/W1592431232","https://openalex.org/W1625092822","https://openalex.org/W1664326306","https://openalex.org/W1671834350","https://openalex.org/W1672565987","https://openalex.org/W1766643663","https://openalex.org/W1773327886","https://openalex.org/W1964847153","https://openalex.org/W1968351694","https://openalex.org/W1978020663","https://openalex.org/W1981347701","https://openalex.org/W1982407164","https://openalex.org/W1983756096","https://openalex.org/W1986578919","https://openalex.org/W1986926122","https://openalex.org/W1991157809","https://openalex.org/W1992794298","https://openalex.org/W1995647920","https://openalex.org/W1997119259","https://openalex.org/W1997208169","https://openalex.org/W2002798780","https://openalex.org/W2004270675","https://openalex.org/W2008081488","https://openalex.org/W2010101508","https://openalex.org/W2012379679","https://openalex.org/W2012788378","https://openalex.org/W2019724237","https://openalex.org/W2024176341","https://openalex.org/W2027974939","https://openalex.org/W2038522823","https://openalex.org/W2039376197","https://openalex.org/W2057820530","https://openalex.org/W2066157848","https://openalex.org/W2068106905","https://openalex.org/W2071157278","https://openalex.org/W2075493708","https://openalex.org/W2081324739","https://openalex.org/W2081520863","https://openalex.org/W2084356344","https://openalex.org/W2085010213","https://openalex.org/W2087019177","https://openalex.org/W2087496921","https://openalex.org/W2094955966","https://openalex.org/W2100837269","https://openalex.org/W2120356456","https://openalex.org/W2121737195","https://openalex.org/W2137139967","https://openalex.org/W2152311269","https://openalex.org/W2154205448","https://openalex.org/W2894728782"],"related_works":["https://openalex.org/W2059882737","https://openalex.org/W2163238032","https://openalex.org/W2042412591","https://openalex.org/W2078255915","https://openalex.org/W2418459153","https://openalex.org/W2019095686","https://openalex.org/W2029362680","https://openalex.org/W7097855564","https://openalex.org/W2012788378","https://openalex.org/W1978020663"],"abstract_inverted_index":{"The":[0,29,58,96,157],"overexpression":[1],"of":[2,19,22,27,31,33,56,62,64,78,80,90,98,139,152,159,161,175,179,189,191,208,217,236,248,254,266,288,291],"phospholipid":[3],"hydroperoxide":[4],"glutathione":[5],"peroxidase":[6],"(PHGPx)":[7],"by":[8,93,195],"RBL-2H3":[9],"cells":[10,42,87,122,167,201,225],"was":[11,117,197,226],"used":[12],"as":[13,110,202,274,285],"the":[14,20,25,69,72,106,133,137,173,186,205,215,233,255,263,289],"basis":[15],"for":[16,262],"an":[17,275],"investigation":[18],"effects":[21],"PHGPx":[23,45,73,91,130,218,242,278],"on":[24],"formation":[26,79,160,190],"leukotrienes.":[28,292],"rates":[30,61,77,158,171],"production":[32,63,290],"leukotriene":[34,38],"C4":[35],"(LTC4)":[36],"and":[37,115,155,163],"B4":[39],"(LTB4)":[40],"in":[41,52,60,71,85,105,120,165,199,246,252,269],"that":[43,123,135,185,214,231,241,259],"overexpressed":[44],"were":[46],"8":[47],"times":[48,228],"lower":[49],"than":[50,230],"those":[51],"a":[53,149,176,282,286],"control":[54,76,170,206,234],"line":[55,235],"cells.":[57,209,237],"reduction":[59],"leukotrienes":[65,81],"apparently":[66,131],"resulted":[67],"from":[68,223,232],"increase":[70],"activity":[74,92],"since":[75,146],"could":[82],"be":[83,244],"achieved":[84],"PHGPx-overexpressing":[86,121,166,200,224],"upon":[88,172],"inhibition":[89],"diethyl":[94],"malate.":[95],"conversion":[97,138],"radioactively":[99],"labeled":[100],"arachidonic":[101,140],"acid":[102,112,141,144,257],"to":[103,142,169,271,280],"intermediates":[104],"lipoxygenase":[107],"pathway,":[108],"such":[109],"5-hydroxyeicosatetraenoic":[111],"(5-HETE),":[113],"LTC4,":[114,154],"LTB4,":[116],"strongly":[118],"inhibited":[119],"had":[124],"been":[125],"prelabeled":[126],"with":[127,204,220],"[14C]arachidonic":[128],"acid.":[129],"inactivated":[132],"5-lipoxygenase":[134,249],"catalyzed":[136],"5-hydroperoxyeicosatetraenoic":[143],"(5-HPETE)":[145],"5-HPETE":[147],"is":[148],"common":[150],"precursor":[151],"5-HETE,":[153],"LTB4.":[156],"LTC4":[162],"LTB4":[164],"returned":[168],"addition":[174,270],"small":[177],"amount":[178,216],"12-HPETE.":[180],"Flow":[181],"cytometric":[182],"analysis":[183,212],"revealed":[184],"rapid":[187],"burst":[188],"lipid":[192],"hydroperoxides":[193,258],"induced":[194],"A23187":[196],"suppressed":[198],"compared":[203],"lines":[207],"Subcellular":[210],"fractionation":[211],"showed":[213],"associated":[219],"nuclear":[221],"fractions":[222],"3.5":[227],"higher":[229],"These":[238],"results":[239],"indicate":[240],"might":[243],"involved":[245],"inactivation":[247],"via":[250],"reductions":[251],"levels":[253],"fatty":[256],"are":[260],"required":[261],"full":[264],"activation":[265],"5-lipoxygenase.":[267],"Thus,":[268],"its":[272],"role":[273],"antioxidant":[276],"enzyme,":[277],"appears":[279],"have":[281],"novel":[283],"function":[284],"modulator":[287]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}