{"id":"https://openalex.org/W2007197177","doi":"https://doi.org/10.1016/j.nbd.2011.01.014","title":"Reduced somatostatin in subgenual anterior cingulate cortex in major depression","display_name":"Reduced somatostatin in subgenual anterior cingulate cortex in major depression","publication_year":2011,"publication_date":"2011-01-12","ids":{"openalex":"https://openalex.org/W2007197177","doi":"https://doi.org/10.1016/j.nbd.2011.01.014","mag":"2007197177","pmid":"https://pubmed.ncbi.nlm.nih.gov/21232602","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039077"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2011.01.014","doi":"https://doi.org/10.1016/j.nbd.2011.01.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nbd.2011.01.014","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039077","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111979942","display_name":"Adam C. Tripp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Tripp","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, PA 15312, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082379518","display_name":"Rama S. Kota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rama S. Kota","raw_affiliation_strings":["Department of Psychiatry, University of Pittsburgh, PA 15312, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084351153","display_name":"David A. Lewis","orcid":"https://orcid.org/0000-0002-3225-6778","observed_orcids":["https://orcid.org/0000-0002-3225-6778"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Lewis","raw_affiliation_strings":["Center For Neuroscience, University of Pittsburgh, PA 15312, USA","Department of Psychiatry, University of Pittsburgh, PA 15312, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center For Neuroscience, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027215336","display_name":"Etienne L. Sibille","orcid":"https://orcid.org/0000-0001-5832-6570","observed_orcids":["https://orcid.org/0000-0001-5832-6570"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Etienne Sibille","raw_affiliation_strings":["Center For Neuroscience, University of Pittsburgh, PA 15312, USA","Department of Psychiatry, University of Pittsburgh, PA 15312, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center For Neuroscience, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Psychiatry, University of Pittsburgh, PA 15312, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027215336"],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":5.3748,"has_fulltext":false,"cited_by_count":190,"citation_normalized_percentile":{"value":0.961331,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"42","issue":"1","first_page":"116","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.8422999978065491,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/subgenual-anterior-cingulate-cortex","display_name":"subgenual anterior cingulate cortex","score":0.9919999837875366},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9959999918937683},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gabaergic-neurons","display_name":"GABAergic neurons","score":0.8830000162124634},{"id":"https://openalex.org/keywords/postmortem-brain","display_name":"postmortem brain","score":0.7739999890327454},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.6970000267028809},{"id":"https://openalex.org/keywords/pathophysiology-of-depression","display_name":"depression pathophysiology","score":0.8140000104904175}],"concepts":[{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.7736426591873169},{"id":"https://openalex.org/C2778402161","wikidata":"https://www.wikidata.org/wiki/Q2121931","display_name":"Anterior cingulate cortex","level":3,"score":0.7431102991104126},{"id":"https://openalex.org/C2780508717","wikidata":"https://www.wikidata.org/wiki/Q72788","display_name":"Dorsolateral prefrontal cortex","level":4,"score":0.6187496185302734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5976548790931702},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.5871619582176208},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5570439696311951},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5449780225753784},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46339279413223267},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4595204293727875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3824664354324341},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37838014960289},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.06998330354690552},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.06716623902320862}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.nbd.2011.01.014","doi":"https://doi.org/10.1016/j.nbd.2011.01.014","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.nbd.2011.01.014","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"pmid:21232602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21232602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2320773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3039077","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039077","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neurobiol Dis","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:567bff2ac6da4c00b7202c47068f72d6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/567bff2ac6da4c00b7202c47068f72d6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 42, Iss 1, Pp 116-124 (2011)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2320773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3039077","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1012154629","display_name":"Inhibition, Oscillations and Information Processing in Schizophrenia","funder_award_id":"P50MH084053","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7588311130","display_name":"Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major Depression","funder_award_id":"R01MH077159","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8057162315","display_name":"Cortical Circuitry and Cognition in Schizophrenia","funder_award_id":"P50MH045156","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8352182201","display_name":"Molecular characterization of a corticolimbic network in depression","funder_award_id":"K02MH084060","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1577577364","https://openalex.org/W1587447328","https://openalex.org/W1642400879","https://openalex.org/W1647455825","https://openalex.org/W1966305254","https://openalex.org/W1966460145","https://openalex.org/W1969171865","https://openalex.org/W1975924674","https://openalex.org/W1979089999","https://openalex.org/W1985339794","https://openalex.org/W1991896842","https://openalex.org/W2007683015","https://openalex.org/W2009928774","https://openalex.org/W2014980234","https://openalex.org/W2019885827","https://openalex.org/W2022211890","https://openalex.org/W2022931883","https://openalex.org/W2026826561","https://openalex.org/W2039643193","https://openalex.org/W2040897211","https://openalex.org/W2046811219","https://openalex.org/W2047801483","https://openalex.org/W2048205572","https://openalex.org/W2048595403","https://openalex.org/W2051067576","https://openalex.org/W2053126345","https://openalex.org/W2057792489","https://openalex.org/W2061038009","https://openalex.org/W2067237160","https://openalex.org/W2074098133","https://openalex.org/W2076515703","https://openalex.org/W2083199782","https://openalex.org/W2085848150","https://openalex.org/W2086710727","https://openalex.org/W2090128083","https://openalex.org/W2096976625","https://openalex.org/W2099302120","https://openalex.org/W2101782576","https://openalex.org/W2104460069","https://openalex.org/W2108043630","https://openalex.org/W2116835712","https://openalex.org/W2125788186","https://openalex.org/W2127765363","https://openalex.org/W2137296158","https://openalex.org/W2144538553","https://openalex.org/W2150347274","https://openalex.org/W2151431569","https://openalex.org/W2153973179","https://openalex.org/W2154265420","https://openalex.org/W2156352029","https://openalex.org/W2162916231","https://openalex.org/W2162933869","https://openalex.org/W2164706220","https://openalex.org/W2167578061","https://openalex.org/W2170696995","https://openalex.org/W2186138755","https://openalex.org/W3026624461"],"related_works":["https://openalex.org/W2044680993","https://openalex.org/W2512833929","https://openalex.org/W2914739864","https://openalex.org/W2153973179","https://openalex.org/W2136371177","https://openalex.org/W4241001787","https://openalex.org/W2161401578","https://openalex.org/W3189877389","https://openalex.org/W1582811168","https://openalex.org/W4385788628"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":22},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}