{"id":"https://openalex.org/W2007186154","doi":"https://doi.org/10.1210/endo-113-5-1907","title":"ESTROGEN-INDUCED CREATINE KINASE IN THE REPRODUCTIVE SYSTEM OF THE IMMATURE FEMALE RAT","display_name":"ESTROGEN-INDUCED CREATINE KINASE IN THE REPRODUCTIVE SYSTEM OF THE IMMATURE FEMALE RAT","publication_year":1983,"publication_date":"1983-11-01","ids":{"openalex":"https://openalex.org/W2007186154","doi":"https://doi.org/10.1210/endo-113-5-1907","mag":"2007186154","pmid":"https://pubmed.ncbi.nlm.nih.gov/6628331"},"language":"en","primary_location":{"id":"doi:10.1210/endo-113-5-1907","doi":"https://doi.org/10.1210/endo-113-5-1907","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-113-5-1907","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073034256","display_name":"Stephen D. H. Malnick","orcid":"https://orcid.org/0000-0003-1865-8313","observed_orcids":["https://orcid.org/0000-0003-1865-8313"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"S.D.H. MALNICK","raw_affiliation_strings":["Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","Department of Hormone Research Rehovot, 76100, Israel","Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. SHAER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A. SHAER","raw_affiliation_strings":["Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","Department of Hormone Research Rehovot, 76100, Israel","Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003680413","display_name":"Hermona Soreq","orcid":"https://orcid.org/0000-0002-0955-526X","observed_orcids":["https://orcid.org/0000-0002-0955-526X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"H. SOREQ","raw_affiliation_strings":["Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","Department of Hormone Research Rehovot, 76100, Israel","Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108221762","display_name":"Alvin M. Kaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A.M. KAYE","raw_affiliation_strings":["Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","Department of Hormone Research Rehovot, 76100, Israel","Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Gerald Litwack","raw_affiliation_strings":["Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","Department of Hormone Research Rehovot, 76100, Israel","Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel.; Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Hormone Research Rehovot, 76100, Israel","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology, The Weizmann Institute of Science Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.1406,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.91975675,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"113","issue":"5","first_page":"1907","last_page":"1909"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8999999761581421},{"id":"https://openalex.org/keywords/brain-creatine-kinase","display_name":"brain creatine kinase","score":0.6740000247955322},{"id":"https://openalex.org/keywords/preoptic-area","display_name":"preoptic area","score":0.8220000267028809},{"id":"https://openalex.org/keywords/anterior-hypothalamus","display_name":"anterior hypothalamus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/median-eminence","display_name":"median eminence","score":1.0},{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.7400000095367432},{"id":"https://openalex.org/keywords/immature-female-rats","display_name":"immature female rats","score":0.824999988079071},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5410000085830688},{"id":"https://openalex.org/keywords/reproductive-system","display_name":"reproductive system","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8543626070022583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8459129929542542},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.8437557220458984},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.7965293526649475},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.6102743148803711},{"id":"https://openalex.org/C36880943","wikidata":"https://www.wikidata.org/wiki/Q409458","display_name":"Creatine kinase","level":2,"score":0.5993908047676086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5662731528282166},{"id":"https://openalex.org/C2779067335","wikidata":"https://www.wikidata.org/wiki/Q1337712","display_name":"Median eminence","level":3,"score":0.4706394374370575},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4614352881908417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20466288924217224}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005836","descriptor_name":"Genitalia, Female","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014621","descriptor_name":"Vagina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-113-5-1907","doi":"https://doi.org/10.1210/endo-113-5-1907","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-113-5-1907","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6628331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6628331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1521281147","https://openalex.org/W1640762172","https://openalex.org/W1670369342","https://openalex.org/W1968771384","https://openalex.org/W1985150210","https://openalex.org/W1990215840","https://openalex.org/W2015216655","https://openalex.org/W2015611519","https://openalex.org/W2038174723","https://openalex.org/W2047946415","https://openalex.org/W2054382126","https://openalex.org/W2064937668","https://openalex.org/W2069788256","https://openalex.org/W2071217354","https://openalex.org/W2073093997","https://openalex.org/W2077146485","https://openalex.org/W2100837269","https://openalex.org/W2128635872","https://openalex.org/W2149573140","https://openalex.org/W2396996934","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2050798643","https://openalex.org/W1998892210","https://openalex.org/W2074228651","https://openalex.org/W2049318839","https://openalex.org/W1996340627","https://openalex.org/W7095561424","https://openalex.org/W2040646620","https://openalex.org/W4254299768","https://openalex.org/W7100538129","https://openalex.org/W2015307060"],"abstract_inverted_index":{"An":[0],"increase":[1,58,90],"in":[2,16,25,59,62,78,87,91],"the":[3,7,17,20,26,34,63,109,118],"biosynthetic":[4],"rate":[5,61],"of":[6,10,33,47,50,112,131],"brain-type":[8],"isozyme":[9,111],"creatine":[11],"kinase":[12],"(CKBB,":[13],"first":[14],"described":[15],"uterus":[18],"as":[19],"\"estrogen-induced":[21],"protein\")":[22],"was":[23,85],"found":[24],"ovary,":[27,64],"vagina":[28],"and":[29,40,84,102],"estrogen":[30,126],"receptor-rich":[31],"regions":[32],"brain":[35],"(preoptic":[36],"area,":[37],"anterior":[38],"hypothalamus":[39],"median":[41],"eminence),":[42],"one":[43],"hour":[44],"after":[45,96],"injection":[46],"5":[48],"micrograms":[49],"estradiol-17":[51],"beta":[52],"into":[53],"25-28":[54],"day-old":[55],"rats.":[56],"The":[57],"synthetic":[60],"detected":[65],"by":[66,127],"35S":[67],"methionine":[68],"incorporation,":[69],"peaked":[70],"at":[71,81],"1h,":[72],"but":[73],"still":[74],"remained":[75],"higher":[76],"than":[77],"control":[79],"ovaries":[80],"6":[82],"h":[83],"reflected":[86],"a":[88,128],"longer-term":[89],"ovarian":[92],"CK":[93],"specific":[94],"activity":[95],"4":[97],"daily":[98],"injections.":[99],"Both":[100],"ovary":[101],"vagina,":[103],"similarly":[104],"to":[105,125],"brain,":[106],"contained":[107],"exclusively":[108],"BB":[110],"CK.":[113],"These":[114],"findings":[115],"suggest":[116],"that":[117],"entire":[119],"female":[120],"reproductive":[121],"system":[122],"can":[123],"respond":[124],"rapid":[129],"induction":[130],"CKBB.":[132]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}