{"id":"https://openalex.org/W2007181087","doi":"https://doi.org/10.1016/j.bbamem.2007.01.011","title":"Different behavior of agmatine in liver mitochondria: Inducer of oxidative stress or scavenger of reactive oxygen species?","display_name":"Different behavior of agmatine in liver mitochondria: Inducer of oxidative stress or scavenger of reactive oxygen species?","publication_year":2007,"publication_date":"2007-01-26","ids":{"openalex":"https://openalex.org/W2007181087","doi":"https://doi.org/10.1016/j.bbamem.2007.01.011","mag":"2007181087","pmid":"https://pubmed.ncbi.nlm.nih.gov/17316555"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbamem.2007.01.011","doi":"https://doi.org/10.1016/j.bbamem.2007.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2007.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bbamem.2007.01.011","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010020812","display_name":"Valentina Battaglia","orcid":"https://orcid.org/0000-0002-5511-4713","observed_orcids":["https://orcid.org/0000-0002-5511-4713"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Battaglia","raw_affiliation_strings":["Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029009485","display_name":"Claudio Rossi","orcid":"https://orcid.org/0000-0001-6032-1015","observed_orcids":["https://orcid.org/0000-0001-6032-1015"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C.A. Rossi","raw_affiliation_strings":["Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027182053","display_name":"Sebastiano Colombatto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Colombatto","raw_affiliation_strings":["Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universit\u00e1 di Torino, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universit\u00e1 di Torino, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108490143","display_name":"MARIA ANGELICA GRILLO","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M.A. Grillo","raw_affiliation_strings":["Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universit\u00e1 di Torino, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universit\u00e1 di Torino, Torino, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024157908","display_name":"Antonio Toninello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Toninello","raw_affiliation_strings":["Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Chimica Biologica, Universit\u00e0 di Padova, Istituto di Neuroscienze del CNR, Padova, Italy","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3870,"currency":"USD","value_usd":3870},"apc_paid":null,"fwci":1.456,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.79555433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"1768","issue":"5","first_page":"1147","last_page":"1153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.18960000574588776,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/agmatine","display_name":"agmatine","score":1.0},{"id":"https://openalex.org/keywords/liver-mitochondria","display_name":"liver mitochondria","score":0.902999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9819999933242798},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7829999923706055},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.722000002861023},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8199999928474426},{"id":"https://openalex.org/keywords/glutathione-oxidation","display_name":"glutathione oxidation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/sulfhydryl-groups","display_name":"sulfhydryl groups","score":0.8960000276565552},{"id":"https://openalex.org/keywords/iron-sulfur-clusters","display_name":"iron-sulfur clusters","score":0.8450000286102295},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2781448169","wikidata":"https://www.wikidata.org/wiki/Q394317","display_name":"Agmatine","level":4,"score":0.8179113864898682},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7517921924591064},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.7242292165756226},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6655759215354919},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6491656303405762},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.6252647042274475},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.5594921708106995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5430760383605957},{"id":"https://openalex.org/C3020377403","wikidata":"https://www.wikidata.org/wiki/Q211016","display_name":"Respiratory chain","level":3,"score":0.5295613408088684},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.5103139281272888},{"id":"https://openalex.org/C60538801","wikidata":"https://www.wikidata.org/wiki/Q7631706","display_name":"Submitochondrial particle","level":3,"score":0.43932870030403137},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4208013415336609},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.17574268579483032},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1034037172794342}],"mesh":[{"descriptor_ui":"D000376","descriptor_name":"Agmatine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008930","descriptor_name":"Mitochondria, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008933","descriptor_name":"Mitochondrial Swelling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016166","descriptor_name":"Free Radical Scavengers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019069","descriptor_name":"Cell Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053078","descriptor_name":"Membrane Potential, Mitochondrial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.bbamem.2007.01.011","doi":"https://doi.org/10.1016/j.bbamem.2007.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2007.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},{"id":"pmid:17316555","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17316555","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/41748","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/41748","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research.unipd.it:11577/1785054","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11577/1785054","pdf_url":null,"source":{"id":"https://openalex.org/S4306402547","display_name":"Padua Research Archive (University of Padova)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138689650","host_organization_name":"University of Padua","host_organization_lineage":["https://openalex.org/I138689650"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.bbamem.2007.01.011","doi":"https://doi.org/10.1016/j.bbamem.2007.01.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbamem.2007.01.011","pdf_url":null,"source":{"id":"https://openalex.org/S4210187475","display_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","issn_l":"0005-2736","issn":["0005-2736","1879-2642"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Biomembranes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W4061485","https://openalex.org/W156116736","https://openalex.org/W1206408452","https://openalex.org/W1506043065","https://openalex.org/W1533321987","https://openalex.org/W1554680374","https://openalex.org/W1562871643","https://openalex.org/W1573955016","https://openalex.org/W1983335371","https://openalex.org/W1983996840","https://openalex.org/W1984689203","https://openalex.org/W1985731963","https://openalex.org/W1985899665","https://openalex.org/W1993717442","https://openalex.org/W1993943473","https://openalex.org/W2000819512","https://openalex.org/W2004087403","https://openalex.org/W2007064404","https://openalex.org/W2020761450","https://openalex.org/W2029088612","https://openalex.org/W2036599441","https://openalex.org/W2039311197","https://openalex.org/W2046432380","https://openalex.org/W2052406949","https://openalex.org/W2063385957","https://openalex.org/W2073918561","https://openalex.org/W2075414867","https://openalex.org/W2078324060","https://openalex.org/W2087518223","https://openalex.org/W2091154394","https://openalex.org/W2093681309","https://openalex.org/W2110769247","https://openalex.org/W2125463704","https://openalex.org/W2155666321","https://openalex.org/W2159302232","https://openalex.org/W2167578561","https://openalex.org/W2171154502","https://openalex.org/W2223031716"],"related_works":["https://openalex.org/W2155232813","https://openalex.org/W2123642960","https://openalex.org/W2981404223","https://openalex.org/W3043311868","https://openalex.org/W6989160411","https://openalex.org/W2160515977","https://openalex.org/W2024434984","https://openalex.org/W2068601760","https://openalex.org/W6998459273","https://openalex.org/W2316205554"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}