{"id":"https://openalex.org/W2007162991","doi":"https://doi.org/10.1523/jneurosci.2406-12.2012","title":"Perisynaptic Chondroitin Sulfate Proteoglycans Restrict Structural Plasticity in an Integrin-Dependent Manner","display_name":"Perisynaptic Chondroitin Sulfate Proteoglycans Restrict Structural Plasticity in an Integrin-Dependent Manner","publication_year":2012,"publication_date":"2012-12-12","ids":{"openalex":"https://openalex.org/W2007162991","doi":"https://doi.org/10.1523/jneurosci.2406-12.2012","mag":"2007162991","pmid":"https://pubmed.ncbi.nlm.nih.gov/23238717","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6621736"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.2406-12.2012","doi":"https://doi.org/10.1523/jneurosci.2406-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2406-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/50/18009.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.jneurosci.org/content/jneuro/32/50/18009.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021433491","display_name":"Clara Orlando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Clara Orlando","raw_affiliation_strings":["Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000729297","display_name":"Jeanne Ster","orcid":"https://orcid.org/0000-0002-7277-9135","observed_orcids":["https://orcid.org/0000-0002-7277-9135"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jeanne Ster","raw_affiliation_strings":["1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075292815","display_name":"Urs Richard Gerber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Urs Gerber","raw_affiliation_strings":["1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051316175","display_name":"James W. Fawcett","orcid":"https://orcid.org/0000-0002-7990-4568","observed_orcids":["https://orcid.org/0000-0002-7990-4568"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James W. Fawcett","raw_affiliation_strings":["2Brain Repair Centre, University of Cambridge, CB2 0PY Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Brain Repair Centre, University of Cambridge, CB2 0PY Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065746899","display_name":"Olivier Raineteau","orcid":"https://orcid.org/0000-0003-4294-2496","observed_orcids":["https://orcid.org/0000-0003-4294-2496"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Olivier Raineteau","raw_affiliation_strings":["1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brain Research Institute, University of Z\u00fcrich/Eidgen\u00f6ssische Technische Hochschule, 8057 Z\u00fcrich, Switzerland, and","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0491,"has_fulltext":true,"cited_by_count":155,"citation_normalized_percentile":{"value":0.95027836,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"32","issue":"50","first_page":"18009","last_page":"18017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.5127000212669373,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.478300005197525,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondroitin-sulfate-proteoglycans","display_name":"chondroitin sulfate proteoglycans","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dendritic-spine-dynamics","display_name":"dendritic spine dynamics","score":0.7599999904632568},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/chondroitinase-abc","display_name":"chondroitinase ABC","score":0.8399999737739563},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8100000023841858},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9739999771118164},{"id":"https://openalex.org/keywords/extracellular-matrix-maturation","display_name":"extracellular matrix maturation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/perineuronal-nets","display_name":"perineuronal nets","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6650000214576721},{"id":"https://openalex.org/keywords/postnatal-brain-development","display_name":"postnatal brain development","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C129987498","wikidata":"https://www.wikidata.org/wiki/Q7168586","display_name":"Perineuronal net","level":3,"score":0.9308348894119263},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.7889441847801208},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.617920458316803},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6129942536354065},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5058650374412537},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.49685004353523254},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49010929465293884},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4722917675971985},{"id":"https://openalex.org/C2775895372","wikidata":"https://www.wikidata.org/wiki/Q5104536","display_name":"Chondroitin sulfate proteoglycan","level":4,"score":0.4707425534725189},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4705051779747009},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.46880629658699036},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.39725521206855774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36177271604537964},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.24271395802497864},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.23402950167655945},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.22814813256263733},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16553854942321777},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13175302743911743}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011508","descriptor_name":"Chondroitin Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019765","descriptor_name":"Chondroitin ABC Lyase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056547","descriptor_name":"CA1 Region, Hippocampal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1523/jneurosci.2406-12.2012","doi":"https://doi.org/10.1523/jneurosci.2406-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2406-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/50/18009.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5604569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6621736","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6621736","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6621736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:23238717","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23238717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/60667","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/60667","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Neuroscience, 32 (50)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-c-000060667","doi":"https://doi.org/10.3929/ethz-c-000060667","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-c-000060667","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.2406-12.2012","doi":"https://doi.org/10.1523/jneurosci.2406-12.2012","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.2406-12.2012","pdf_url":"https://www.jneurosci.org/content/jneuro/32/50/18009.full.pdf","source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306485","display_name":"Christopher and Dana Reeve Foundation","ror":"https://ror.org/0430rna51"},{"id":"https://openalex.org/F4320320273","display_name":"University of Cambridge","ror":"https://ror.org/013meh722"},{"id":"https://openalex.org/F4320322909","display_name":"Isaac Newton Trust","ror":"https://ror.org/02gn6ta77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2007162991.pdf","grobid_xml":"https://content.openalex.org/works/W2007162991.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W42491557","https://openalex.org/W1647836033","https://openalex.org/W1966194315","https://openalex.org/W1977423896","https://openalex.org/W1977637789","https://openalex.org/W1978133911","https://openalex.org/W1990142376","https://openalex.org/W1998122821","https://openalex.org/W1998123755","https://openalex.org/W2003726233","https://openalex.org/W2011562444","https://openalex.org/W2012928251","https://openalex.org/W2015986915","https://openalex.org/W2023371114","https://openalex.org/W2023642934","https://openalex.org/W2032124585","https://openalex.org/W2037289953","https://openalex.org/W2039539900","https://openalex.org/W2044895919","https://openalex.org/W2054463474","https://openalex.org/W2061497228","https://openalex.org/W2068815747","https://openalex.org/W2069377303","https://openalex.org/W2072133859","https://openalex.org/W2074439158","https://openalex.org/W2074562018","https://openalex.org/W2078474557","https://openalex.org/W2082407289","https://openalex.org/W2082833517","https://openalex.org/W2088475496","https://openalex.org/W2089657508","https://openalex.org/W2091187766","https://openalex.org/W2099134671","https://openalex.org/W2106489369","https://openalex.org/W2107012136","https://openalex.org/W2109129502","https://openalex.org/W2122092731","https://openalex.org/W2123940254","https://openalex.org/W2126017421","https://openalex.org/W2136830964","https://openalex.org/W2141532154","https://openalex.org/W2147452663","https://openalex.org/W2148772496","https://openalex.org/W2157650341","https://openalex.org/W2159022089","https://openalex.org/W2162770409","https://openalex.org/W2164796150"],"related_works":["https://openalex.org/W2071272614","https://openalex.org/W2322330802","https://openalex.org/W1501290763","https://openalex.org/W114992317","https://openalex.org/W2109129502","https://openalex.org/W1987632300","https://openalex.org/W2329406651","https://openalex.org/W2098974321","https://openalex.org/W2040004836","https://openalex.org/W2069377303"],"abstract_inverted_index":{"During":[0],"early":[1],"postnatal":[2],"development":[3],"of":[4,17,22,29,39,62,91,118,126,131,145,152,168,172,191,214,220,233],"the":[5,12,20,37,40,59,63,71,80,124,143,150,166,230],"CNS,":[6],"neuronal":[7],"networks":[8],"are":[9,55,76],"configured":[10],"through":[11],"formation,":[13],"elimination,":[14],"and":[15,44,103,148,170,179],"remodeling":[16],"dendritic":[18,48,134,146,195,208],"spines,":[19],"sites":[21],"most":[23],"excitatory":[24],"synaptic":[25,177],"connections.":[26],"The":[27],"closure":[28],"this":[30],"critical":[31],"period":[32],"for":[33,107,229],"plasticity":[34,69],"correlates":[35],"with":[36,184],"maturation":[38],"extracellular":[41,81],"matrix":[42],"(ECM)":[43],"results":[45],"in":[46,70,79,105,156,223,235,239],"reduced":[47],"spine":[49,135,153,201],"dynamics.":[50,136],"Chondroitin":[51],"sulfate":[52],"proteoglycans":[53],"(CSPGs)":[54],"thought":[56],"to":[57,110,122,194,199],"be":[58],"active":[60],"components":[61],"mature":[64,224],"ECM":[65,112],"that":[66,139,204],"inhibit":[67],"functional":[68,237],"adult":[72],"CNS.":[73],"These":[74,161],"molecules":[75],"diffusely":[77],"expressed":[78],"space":[82],"or":[83],"aggregated":[84],"as":[85],"perineuronal":[86,215],"nets":[87],"around":[88,207],"specific":[89],"classes":[90],"neurons.":[92],"We":[93,114,137],"used":[94],"organotypic":[95],"hippocampal":[96],"slices":[97],"prepared":[98],"from":[99],"6-d-old":[100],"Thy1-YFP":[101],"mice":[102],"maintained":[104],"culture":[106],"4":[108],"weeks":[109],"allow":[111],"maturation.":[113],"performed":[115],"live":[116],"imaging":[117],"CA1":[119],"pyramidal":[120],"cells":[121],"assess":[123],"effect":[125],"chondroitinase":[127],"ABC":[128],"(ChABC)-mediated":[129],"digestion":[130,141],"CSPGs":[132,205,222],"on":[133],"found":[138],"CSPG":[140],"enhanced":[142],"motility":[144],"spines":[147,209],"induced":[149],"appearance":[151],"head":[154],"protrusions":[155],"a":[157,185],"glutamate":[158],"receptor-independent":[159],"manner.":[160],"changes":[162],"were":[163,180],"paralleled":[164],"by":[165,182],"activation":[167],"\u03b21-integrins":[169],"phosphorylation":[171],"focal":[173],"adhesion":[174],"kinase":[175],"at":[176],"sites,":[178],"prevented":[181],"preincubation":[183],"\u03b21-integrin":[186],"blocking":[187],"antibody.":[188],"Interestingly,":[189],"microinjection":[190],"ChABC":[192,234],"close":[193],"segments":[196],"was":[197],"sufficient":[198],"induce":[200],"remodeling,":[202],"demonstrating":[203],"located":[206],"modulate":[210],"their":[211],"dynamics":[212],"independently":[213],"nets.":[216],"This":[217],"restrictive":[218],"action":[219],"perisynaptic":[221],"neural":[225,241],"tissue":[226],"may":[227],"account":[228],"therapeutic":[231],"effects":[232],"promoting":[236],"recovery":[238],"impaired":[240],"circuits.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
