{"id":"https://openalex.org/W2007146874","doi":"https://doi.org/10.1073/pnas.1202421109","title":"The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans","display_name":"The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans","publication_year":2012,"publication_date":"2012-03-06","ids":{"openalex":"https://openalex.org/W2007146874","doi":"https://doi.org/10.1073/pnas.1202421109","mag":"2007146874","pmid":"https://pubmed.ncbi.nlm.nih.gov/22396595","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3311396"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1202421109","doi":"https://doi.org/10.1073/pnas.1202421109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1202421109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3311396/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102027405","display_name":"Zhen Shi","orcid":"https://orcid.org/0009-0005-8502-7978","observed_orcids":["https://orcid.org/0009-0005-8502-7978","https://orcid.org/0000-0001-7560-1810"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhen Shi","raw_affiliation_strings":["Biological Sciences in Dental Medicine Program and","Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and","Department of Molecular Biology Massachusetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Sciences in Dental Medicine Program and","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Molecular Biology Massachusetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066998461","display_name":"Gary Ruvkun","orcid":"https://orcid.org/0000-0002-7473-8484","observed_orcids":["https://orcid.org/0000-0002-7473-8484"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Ruvkun","raw_affiliation_strings":["Department of Genetics, Harvard Medical School, Boston, MA 02115","Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114; and","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4022,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.80059256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"109","issue":"12","first_page":"4568","last_page":"4573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":1.0},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mirna-induced-silencing-complex","display_name":"miRNA-induced silencing complex","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mrna-silencing","display_name":"mRNA silencing","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dolichyl-phosphate","display_name":"dolichol phosphate","score":0.9290000200271606},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.8230000138282776},{"id":"https://openalex.org/keywords/sterol-biosynthesis","display_name":"sterol biosynthesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.6830000281333923},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C2781446604","wikidata":"https://www.wikidata.org/wiki/Q418203","display_name":"Dolichol","level":4,"score":0.9240677356719971},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8016689419746399},{"id":"https://openalex.org/C73766848","wikidata":"https://www.wikidata.org/wiki/Q5262529","display_name":"Derepression","level":5,"score":0.7794381380081177},{"id":"https://openalex.org/C2779982574","wikidata":"https://www.wikidata.org/wiki/Q14913010","display_name":"Mevalonate pathway","level":4,"score":0.6559173464775085},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6176594495773315},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.5816929936408997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5489826202392578},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5225000977516174},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5153878927230835},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.4944579601287842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4811447858810425},{"id":"https://openalex.org/C201853390","wikidata":"https://www.wikidata.org/wiki/Q413236","display_name":"Argonaute","level":5,"score":0.43285804986953735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4248661398887634},{"id":"https://openalex.org/C30324644","wikidata":"https://www.wikidata.org/wiki/Q3334151","display_name":"N-linked glycosylation","level":4,"score":0.41020333766937256},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2895127534866333},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.2852974832057953},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.208848774433136},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19054818153381348},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14403602480888367},{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.08362695574760437}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004288","descriptor_name":"Dolichol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006904","descriptor_name":"Hydroxymethylglutaryl-CoA Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008798","descriptor_name":"Mevalonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009844","descriptor_name":"Oligosaccharides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.1202421109","doi":"https://doi.org/10.1073/pnas.1202421109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1202421109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:22396595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22396595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3311396","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3311396/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3311396","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3311396/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5270864803","display_name":"Modified nucleotide cofactors and the interaction of the RNAome with the proteome","funder_award_id":"R01GM098647","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7529403002","display_name":"Control of C. elegans Lineage by Heterochronic Genes","funder_award_id":"R01GM044619","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1920303762","https://openalex.org/W1973699456","https://openalex.org/W1976190898","https://openalex.org/W1982164848","https://openalex.org/W1985175917","https://openalex.org/W1986356875","https://openalex.org/W1986737010","https://openalex.org/W1990388569","https://openalex.org/W2007463943","https://openalex.org/W2013953164","https://openalex.org/W2018507242","https://openalex.org/W2026051181","https://openalex.org/W2040318443","https://openalex.org/W2050143830","https://openalex.org/W2057318017","https://openalex.org/W2062376760","https://openalex.org/W2067008621","https://openalex.org/W2071097995","https://openalex.org/W2071124826","https://openalex.org/W2096842515","https://openalex.org/W2101177020","https://openalex.org/W2116362436","https://openalex.org/W2118105142","https://openalex.org/W2120141187","https://openalex.org/W2123580197","https://openalex.org/W2128016761","https://openalex.org/W2129232972","https://openalex.org/W2130801271","https://openalex.org/W2134427448","https://openalex.org/W2138664009","https://openalex.org/W2154841861","https://openalex.org/W2155820299","https://openalex.org/W2160467221","https://openalex.org/W2162877470","https://openalex.org/W2163199119","https://openalex.org/W2166234597","https://openalex.org/W2167884543"],"related_works":["https://openalex.org/W2169028891","https://openalex.org/W7096575399","https://openalex.org/W7096898793","https://openalex.org/W3043648042","https://openalex.org/W1507780258","https://openalex.org/W2124488953","https://openalex.org/W2789603520","https://openalex.org/W2550669129","https://openalex.org/W1968094383","https://openalex.org/W2171530236"],"abstract_inverted_index":{"The":[0,123],"mevalonate":[1,39,63,92,145],"pathway":[2,40,64,112],"is":[3],"highly":[4],"conserved":[5],"and":[6,24],"mediates":[7],"the":[8,33,38,44,62,76,91,100,110,144,154],"production":[9],"of":[10,37,46,55,61,67,75,99,109,113,119],"isoprenoids,":[11],"which":[12,142],"feed":[13],"into":[14],"biosynthetic":[15,35],"pathways":[16],"for":[17,43,104],"sterols,":[18],"dolichol,":[19],"ubiquinone,":[20],"heme,":[21],"isopentenyl":[22],"adenine,":[23],"prenylated":[25],"proteins.":[26],"We":[27],"found":[28],"that":[29,57,125],"in":[30,49,82],"Caenorhabditis":[31],"elegans,":[32],"nonsterol":[34],"outputs":[36],"are":[41,129],"required":[42],"activity":[45],"microRNAs":[47],"(miRNAs)":[48],"silencing":[50,84],"their":[51],"target":[52,70,121],"mRNAs.":[53,122],"Inactivation":[54],"genes":[56],"mediate":[58,126],"multiple":[59],"steps":[60],"causes":[65,117],"derepression":[66,118],"several":[68],"miRNA":[69,77,120,127,149],"genes,":[71],"with":[72],"no":[73],"disruption":[74],"levels,":[78],"suggesting":[79],"a":[80,96],"role":[81],"miRNA-induced":[83],"complex":[85],"activity.":[86],"Dolichol":[87],"phosphate,":[88],"synthesized":[89],"from":[90],"pathway,":[93,146],"functions":[94],"as":[95,140,151,153],"lipid":[97],"carrier":[98],"oligosaccharide":[101],"moiety":[102],"destined":[103],"protein":[105,114],"N-linked":[106],"glycosylation.":[107],"Inhibition":[108],"dolichol":[111],"N-glycosylation":[115],"also":[116],"proteins":[124],"repression":[128,150],"therefore":[130],"likely":[131],"to":[132],"be":[133],"regulated":[134],"by":[135],"N-glycosylation.":[136],"Conversely,":[137],"drugs":[138],"such":[139],"statins,":[141],"inhibit":[143],"may":[147],"compromise":[148],"well":[152],"more":[155],"commonly":[156],"considered":[157],"cholesterol":[158],"biosynthesis.":[159]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}