{"id":"https://openalex.org/W2007145185","doi":"https://doi.org/10.2174/1568011043352830","title":"Novel Oncogenic Protein Kinase Inhibitors for Cancer Therapy","display_name":"Novel Oncogenic Protein Kinase Inhibitors for Cancer Therapy","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2007145185","doi":"https://doi.org/10.2174/1568011043352830","mag":"2007145185","pmid":"https://pubmed.ncbi.nlm.nih.gov/15379702"},"language":"en","primary_location":{"id":"doi:10.2174/1568011043352830","doi":"https://doi.org/10.2174/1568011043352830","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568011043352830","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry-Anti-Cancer Agents","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113494503","display_name":"Tomi K. Sawyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156154","display_name":"ARIAD Pharmaceuticals (United States)","ror":"https://ror.org/01dwtyk53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I4387156154","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tomi Sawyer","raw_affiliation_strings":["ARIAD Pharmaceuticals, Inc., 26 Landsdowne St., Cambridge, MA 01772, USA. tomi.sawyer@ariad.com","ARIAD Pharmaceuticals, Inc., 26 Landsdowne St., Cambridge, MA 01772, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARIAD Pharmaceuticals, Inc., 26 Landsdowne St., Cambridge, MA 01772, USA. tomi.sawyer@ariad.com","institution_ids":["https://openalex.org/I4387156154"]},{"raw_affiliation_string":"ARIAD Pharmaceuticals, Inc., 26 Landsdowne St., Cambridge, MA 01772, USA","institution_ids":["https://openalex.org/I4387156154"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113494503"],"corresponding_institution_ids":["https://openalex.org/I4387156154"],"apc_list":null,"apc_paid":null,"fwci":2.7601,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.89137106,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"5","first_page":"449","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.4440999925136566,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.4440999925136566,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.23569999635219574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.19859999418258667,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-inhibitors","display_name":"protein kinase inhibitors","score":0.8759999871253967},{"id":"https://openalex.org/keywords/small-molecule-drug-discovery","display_name":"small molecule drug discovery","score":0.847000002861023},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.9350000023841858},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7860000133514404},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atp-binding-site","display_name":"ATP binding site","score":0.9089999794960022},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7440000176429749},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5695279240608215},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49192333221435547},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4761357605457306},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4540383219718933},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45306405425071716},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4487690329551697},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.44459348917007446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3845371901988983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36130446195602417},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.356886088848114}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019992","descriptor_name":"Databases as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1568011043352830","doi":"https://doi.org/10.2174/1568011043352830","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1568011043352830","pdf_url":null,"source":{"id":"https://openalex.org/S159246083","display_name":"Anti-Cancer Agents in Medicinal Chemistry","issn_l":"1568-0118","issn":["1568-0118","1871-5206","1875-5968","1875-5992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry-Anti-Cancer Agents","raw_type":"journal-article"},{"id":"pmid:15379702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15379702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry. Anti-cancer agents","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2321063763","https://openalex.org/W2150814991","https://openalex.org/W2395541711","https://openalex.org/W2029323837","https://openalex.org/W2912941169","https://openalex.org/W2027911638","https://openalex.org/W284991352","https://openalex.org/W2320148073","https://openalex.org/W2160930114","https://openalex.org/W178368023"],"abstract_inverted_index":{"Small-molecule":[0],"drug":[1,38,55,76,86,89],"discovery":[2,56],"for":[3],"cancer":[4],"therapy":[5],"is":[6,57],"making":[7],"extraordinary":[8],"progress":[9],"within":[10],"the":[11,65],"realm":[12],"of":[13,22,68],"advancing":[14],"novel":[15,50],"oncogenic":[16,51,69,82],"protein":[17,52,83,103],"kinase":[18,53,70,104],"inhibitor":[19,54],"lead":[20],"compounds":[21],"significant":[23],"impact":[24],"to":[25,43,60,78],"both":[26],"basic":[27],"research":[28],"and":[29,36],"clinical":[30],"testing.":[31],"In":[32],"this":[33],"perspective,":[34],"structure-":[35],"mechanism-based":[37,88],"design":[39],"are":[40],"highlighted":[41,58],"relative":[42,59],"such":[44],"progress.":[45],"Also,":[46],"evolving":[47],"concepts":[48],"in":[49],"therapeutic":[61],"target":[62],"selectivity,":[63,105],"including":[64],"recent":[66],"identification":[67],"mutants":[71],"effecting":[72],"drug-resistance":[73],"or":[74],"enhanced":[75],"susceptibility":[77],"small-molecule":[79],"inhibitors.":[80],"Keywords:":[81],"kinase,":[84,93,96,99],"structure-based":[85],"design,":[87,90],"receptor":[91],"tyrosine":[92,95],"non-receptor":[94,97],"serine/threonine":[98],"atp":[100],"binding":[101],"site,":[102],"sti-571,":[106],"bms-354825":[107]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-10T00:00:00"}
