{"id":"https://openalex.org/W2007135377","doi":"https://doi.org/10.3109/02656738509029282","title":"Calmodulin inhibitors potentiate hyperthermic cell killing","display_name":"Calmodulin inhibitors potentiate hyperthermic cell killing","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W2007135377","doi":"https://doi.org/10.3109/02656738509029282","mag":"2007135377","pmid":"https://pubmed.ncbi.nlm.nih.gov/3915313"},"language":"en","primary_location":{"id":"doi:10.3109/02656738509029282","doi":"https://doi.org/10.3109/02656738509029282","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02656738509029282","pdf_url":null,"source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113487487","display_name":"F. A. C. Wiegant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. A. C. Wiegant","raw_affiliation_strings":["Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055425548","display_name":"Mark Tuyl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. Tuyl","raw_affiliation_strings":["Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073010010","display_name":"Wilbert A. M. Linnemans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. A. M. Linnemans","raw_affiliation_strings":["Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, State University of Utrecht, Padualaan 8, 3584, CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":{"value":2085,"currency":"GBP","value_usd":2557},"apc_paid":null,"fwci":0.7704,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.67681039,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"2","first_page":"157","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/calmodulin-antagonists","display_name":"calmodulin antagonists","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cytoskeletal-alterations","display_name":"cytoskeletal alterations","score":0.9010000228881836},{"id":"https://openalex.org/keywords/neuro-2a-cells","display_name":"N2a cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/trifluoperazine","display_name":"trifluoperazine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/compound-48-80","display_name":"compound 48/80","score":0.984000027179718},{"id":"https://openalex.org/keywords/calmidazolium","display_name":"calmidazolium","score":0.9900000095367432},{"id":"https://openalex.org/keywords/heat-shock-response","display_name":"heat shock response","score":0.8769999742507935},{"id":"https://openalex.org/keywords/heat-shock-proteins","display_name":"heat shock proteins","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.8992848992347717},{"id":"https://openalex.org/C2775891158","wikidata":"https://www.wikidata.org/wiki/Q1752915","display_name":"Trifluoperazine","level":4,"score":0.7607828974723816},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7418845891952515},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7382047176361084},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7347610592842102},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.55742347240448},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4584919512271881},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4515851140022278},{"id":"https://openalex.org/C137984847","wikidata":"https://www.wikidata.org/wiki/Q1621258","display_name":"Heat shock","level":4,"score":0.42961984872817993},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4207667112350464},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3702705502510071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34542346000671387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20477095246315002},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1417536437511444},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002147","descriptor_name":"Calmodulin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003189","descriptor_name":"p-Methoxy-N-methylphenethylamine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007093","descriptor_name":"Imidazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014268","descriptor_name":"Trifluoperazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02656738509029282","doi":"https://doi.org/10.3109/02656738509029282","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02656738509029282","pdf_url":null,"source":{"id":"https://openalex.org/S107381699","display_name":"International Journal of Hyperthermia","issn_l":"0265-6736","issn":["0265-6736","1464-5157"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Hyperthermia","raw_type":"journal-article"},{"id":"pmid:3915313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3915313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W58106746","https://openalex.org/W1485295524","https://openalex.org/W1552839202","https://openalex.org/W1596807288","https://openalex.org/W1903231347","https://openalex.org/W1906034670","https://openalex.org/W1968113872","https://openalex.org/W1973307878","https://openalex.org/W1978093100","https://openalex.org/W1996644939","https://openalex.org/W1996961377","https://openalex.org/W2005468807","https://openalex.org/W2010424836","https://openalex.org/W2015392395","https://openalex.org/W2029169169","https://openalex.org/W2031662700","https://openalex.org/W2047848482","https://openalex.org/W2049454330","https://openalex.org/W2053082340","https://openalex.org/W2053419780","https://openalex.org/W2053914489","https://openalex.org/W2065466040","https://openalex.org/W2080452204","https://openalex.org/W2090712867","https://openalex.org/W2094263614","https://openalex.org/W2094557223","https://openalex.org/W2100837269","https://openalex.org/W2141587571","https://openalex.org/W2150671010","https://openalex.org/W2151882378","https://openalex.org/W2156828728","https://openalex.org/W2202347873","https://openalex.org/W2322016291","https://openalex.org/W2332486747","https://openalex.org/W2334413025","https://openalex.org/W2401211739","https://openalex.org/W2409521202","https://openalex.org/W2461649126","https://openalex.org/W2496021568","https://openalex.org/W2513364998","https://openalex.org/W2898043218","https://openalex.org/W4231721248","https://openalex.org/W4298328548","https://openalex.org/W4300499393","https://openalex.org/W7095995388","https://openalex.org/W7098673162"],"related_works":["https://openalex.org/W2066866377","https://openalex.org/W1583029243","https://openalex.org/W2051461237","https://openalex.org/W2043029708","https://openalex.org/W4302084345","https://openalex.org/W2316499537","https://openalex.org/W7100925998","https://openalex.org/W2153475069","https://openalex.org/W2326233937","https://openalex.org/W2010505983"],"abstract_inverted_index":{"The":[0,49,62],"role":[1],"of":[2,9,46,64,79,85,95,123,132],"calmodulin":[3],"(CaM)":[4],"in":[5,40,57,89,98],"cellular":[6,134],"heat":[7,47,86,135],"injury":[8],"neuroblastoma":[10],"N2A":[11],"and":[12,26,70,119],"hepatoma":[13],"H35":[14],"cells":[15],"has":[16],"been":[17],"investigated,":[18],"using":[19],"specific":[20],"calmodulin-inhibiting":[21],"drugs":[22,30],"(Trifluoperazine,":[23],"Compound":[24],"48/80":[25],"Calmidazolium).":[27],"These":[28],"CaM-specific":[29],"potentiate":[31],"hyperthermia-induced":[32,54],"cell":[33,59,117],"killing,":[34],"suggesting":[35],"CaM":[36,50,65,105,124],"to":[37,72,75,127],"be":[38,73,128],"involved":[39],"processes":[41],"aimed":[42],"on":[43],"the":[44,58,76,80,93,104,133],"repair":[45],"injury.":[48],"inhibitors":[51,66],"also":[52],"prevent":[53],"cytoskeletal":[55,120],"alterations":[56],"types":[60],"studied.":[61],"action":[63],"was":[67,108],"dose":[68],"dependent,":[69],"seems":[71],"confined":[74],"first":[77],"period":[78],"hyperthermic":[81,116],"treatment.":[82],"Neither":[83],"production":[84],"shock":[87,136],"proteins":[88],"heat-shocked":[90],"cultures,":[91],"nor":[92],"rate":[94],"protein":[96],"synthesis":[97],"control":[99],"cultures":[100],"were":[101],"affected":[102],"by":[103],"inhibitors.":[106],"It":[107],"concluded":[109],"that":[110],"an":[111],"inverse":[112],"correlation":[113],"exists":[114],"between":[115],"killing":[118],"alterations.":[121],"Activation":[122],"is":[125],"suggested":[126],"a":[129],"fundamental":[130],"aspect":[131],"response.":[137]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}